Neuroscience and Behavior
Behavioral Analysis in Neurological Research
Neuroscience and Behavior
Neuroscience serves as the scientific exploration of the nervous system, encompassing the brain, spinal cord, and peripheral nerves. This multidisciplinary field aims to unravel further understanding into brain function and cognitive decision making, drawing insights from biology, psychology, chemistry, and computer science. Central to neuroscience is an understanding of neuroanatomy, neurotransmitters and signaling, and behavioral paradigms. The study of neuroanatomy focuses on the intricate structures of the nervous system, where various brain regions, including the cortex, limbic system, and brainstem, govern different functions from cognition to basic life support. In conjunction with neurotransmitters and signaling pathways, researchers decipher the complex communication networks that underpin behavior and cognition, often revealing the dysregulations implicated in neurological and psychiatric disorders. The result of nervous activity allows for scientists to further study behavioral paradigms to connect neural mechanisms with observable behaviors, providing a comprehensive view of how brain processes translate into actions and experiences.
Basic Neuroanatomy
Neuroanatomy provides the foundational understanding of the brain's structure and function. Key structures such as the cortex, responsible for higher cognitive functions, and the limbic system, which regulates emotions and memory, guide researchers in pinpointing brain regions involved in specific behaviors or affected by neurological disorders. Additionally, the brainstem, governing vital functions like breathing and heart rate, underscores the critical role of neuroanatomy in comprehending the intricacies of the nervous system.
Neurotransmitters and Signaling
Neurons communicate through chemical signals called neurotransmitters, which play pivotal roles in regulating behavior and mood. Serotonin, dopamine, and acetylcholine are among the common neurotransmitters, each exerting distinct effects on neuronal activity and behavior. Understanding neurotransmitter signaling pathways involves deciphering the release, reception, and subsequent effects of neurotransmitters, shedding light on the intricate mechanisms governing brain function and behavior. Dysregulation of these systems often manifests in neurological and psychiatric disorders, underscoring their significance in pre-clinical neuroscience research.
Behavioral Paradigms
Behavioral paradigms serve as standardized experimental tasks employed in pre-clinical studies to assess various aspects of behavior in animal models. Tasks such as the Morris water maze, open field test, and elevated plus maze offer insights into spatial learning, locomotor activity, anxiety-like behavior, and more. These paradigms provide researchers with invaluable tools to study behavior systematically, evaluate the effects of experimental manipulations, and gain insights into the neural circuits underlying specific behaviors and responses.
Applications
Neurodegenerative Disorders
Neurodegenerative disorders involve progressive degeneration and loss of neurons in the brain or spinal cord, leading to cognitive and motor impairments. Common neurodegenerative diseases include Alzheimer's disease, Parkinson's disease, and Huntington's disease. Pre-clinical research endeavors to unravel the molecular and cellular mechanisms driving neurodegeneration, identify biomarkers for early diagnosis, and develop disease-modifying therapies. Animal models play a crucial role in studying disease progression, testing potential treatments, and exploring novel therapeutic targets for neurodegenerative disorders.
Neurodevelopmental Disorders
Neurodevelopmental disorders encompass a range of conditions characterized by impairments in neurological development and functioning. Prominent examples include autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and intellectual disabilities. Pre-clinical research in this field investigates the genetic, environmental, and neurobiological factors contributing to these disorders. Animal models are instrumental in mimicking symptoms and studying underlying mechanisms, aiding in the development of targeted interventions and treatments.
Neuropharmacology
Neuropharmacology delves into the effects of drugs and compounds on the nervous system, aiming to modulate neurotransmitter systems to understand their roles in behavior and disease. Through the use of pharmacological agents, researchers manipulate neurotransmitter systems in pre-clinical studies to elucidate their impact on behavior and neurobiology. This research avenue is instrumental in uncovering potential therapeutic targets for neurological and psychiatric disorders and developing novel treatment strategies to alleviate symptoms and improve patient outcomes.
Columbus Instruments
Neuroscience and Behavior
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Alzheimer's Disease
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Anorexia
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Anxiety Disorders
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Arthritis
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Autism
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Cachexia
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Cardiovascular
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Dementia
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Depression
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Diabetes
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Dietary Supplements
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Drug Abuse (NIDA only)
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Endocrine Disruptors
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Heart Disease
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Hypertension
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Kidney Disease
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Mental Health
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Microbiome
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Multiple Sclerosis
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Muscular Dystrophy
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Neurodegenerative
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Neurosciences
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Nutrition
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Obesity
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Osteoporosis
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Pain
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Parkinson's Disease
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Physical Activity
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Regenerative Medicine
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Rehabilitation
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Rett Syndrome
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Rheumatoid Arthritis
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Sarcopenia
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Schizophrenia
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Sleep Research
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Spinal Cord Injury
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Stroke
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Urologic Diseases
Discover unparalleled precision and accuracy with Columbus Instruments
The Comprehensive Lab Animal Monitoring System allows for 24-hour, automated, non-invasive collection of several physiological and behavioral parameters.
The Comprehensive Lab Animal Monitoring System allows for 24-hour, automated, non-invasive collection of several physiological and behavioral parameters.
Columbus Instruments treadmills are state-of-the-art systems engineered for automated, non-invasive monitoring of laboratory animal activity, delivering precise and reliable data for physiology and behavior research.
Columbus Instruments treadmills are state-of-the-art systems engineered for automated, non-invasive monitoring of laboratory animal activity, delivering precise and reliable data for physiology and behavior research.
Precisely controlled enclosures for regulating temperature and light conditions in research studies.
Precisely controlled enclosures for regulating temperature and light conditions in research studies.
The Columbus Instruments Mouse Home Cage Running Wheel measures spontaneous activity in a voluntary free-spinning running wheel. The wheel is constructed to fit universally into most typical "shoebox" style cages (cage is not included with the system). Each wheel has a magnetic indicator and a hall effect sensor that connects to a computer interface and records wheel revolutions at user-specified intervals. Windows software is included for installation on a customer supplied PC. Data can be viewed in real time and exported into a CSV format at the end of the experiment.
The Columbus Instruments Mouse Home Cage Running Wheel measures spontaneous activity in a voluntary free-spinning running wheel. The wheel is constructed to fit universally into most typical "shoebox" style cages (cage is not included with the system). Each wheel has a magnetic indicator and a hall effect sensor that connects to a computer interface and records wheel revolutions at user-specified intervals. Windows software is included for installation on a customer supplied PC. Data can be viewed in real time and exported into a CSV format at the end of the experiment.
Exer-3/6, currently in its 4th generation, is a general purpose three (rats) or six (mice) lane animal exerciser utilizing single belt construction with dividing walls suspended over the tread surface.
Exer-3/6, currently in its 4th generation, is a general purpose three (rats) or six (mice) lane animal exerciser utilizing single belt construction with dividing walls suspended over the tread surface.
This unique, single lane, treadmill for mice provides an unobstructed view of animal foot location on a clear tread belt.
This unique, single lane, treadmill for mice provides an unobstructed view of animal foot location on a clear tread belt.
A precisely engineered instrument designed for reliable and consistent measurement of neurological conditions.
A precisely engineered instrument designed for reliable and consistent measurement of neurological conditions.
The Grip Strength Meter is employed in assessing neuromuscular function using efficiently designed pull bar assemblies.
The Grip Strength Meter is employed in assessing neuromuscular function using efficiently designed pull bar assemblies.
A rapid and efficient instrument designed to accurately assess pain relief levels in small laboratory animals.
A rapid and efficient instrument designed to accurately assess pain relief levels in small laboratory animals.
Allows each animal to exercise within an isolated space. An exercise belt, associated pulleys and optional stimuli are enclosed in a compartment which can be made air-tight
Allows each animal to exercise within an isolated space. An exercise belt, associated pulleys and optional stimuli are enclosed in a compartment which can be made air-tight
The Columbus Instruments Mouse Home Cage Running Wheel measures spontaneous activity in a voluntary free-spinning running wheel.
The Columbus Instruments Mouse Home Cage Running Wheel measures spontaneous activity in a voluntary free-spinning running wheel.
A precise, non-invasive blood pressure monitor that accurately measures systolic, diastolic, and mean arterial pressure.
A precise, non-invasive blood pressure monitor that accurately measures systolic, diastolic, and mean arterial pressure.
Multi-axis activity monitor for flexible, high-precision tracking of subject movement.
Multi-axis activity monitor for flexible, high-precision tracking of subject movement.
Automated animal activity meter for measuring locomotor activity, stereotypic movement, vertical movement, time in square, and animal path.
Automated animal activity meter for measuring locomotor activity, stereotypic movement, vertical movement, time in square, and animal path.
Designed to accurately measure the vertical component of motion associated with the startle reflex.
Designed to accurately measure the vertical component of motion associated with the startle reflex.
A multi-station rotation monitoring system that records full and partial turning motion in small laboratory animals.
A multi-station rotation monitoring system that records full and partial turning motion in small laboratory animals.
Implementation of the classic Rota-rod, designed to measure motor coordination, balance, and endurance in small animals.
Implementation of the classic Rota-rod, designed to measure motor coordination, balance, and endurance in small animals.
Custom-built home cage running wheels engineered for precise and reliable measurement of spontaneous activity in subjects.
Custom-built home cage running wheels engineered for precise and reliable measurement of spontaneous activity in subjects.
A highly adaptable general purpose closed circuit respirometer with very high sensitivity.
- Biodegradation
- ASTM D5511
- ISO 15985
- Etc.
- ISO 14851:2019
- ISO 14852:2018
- ISO 14853:2016
- Etc.
- ASTM D5538
- EN 13432
- ISO 14855
- Etc.
- ASTM D6691
- ISO 222403:2020
- Etc.
- OECD 301 B
- OECD 301
- OECD 301 F
- OECD 302B
- ASTM D5209
- ASTM D5210
- ASTM D5271
- Etc.
- ASTM D5988
- ISO 17556:2019
- Etc.
- Bioremediation
- Bioleaching
- Clean Energy
- Toxicity
- Insect Respiration
A gas blender that provides a continuous flow of mixed gases from pure gas sources.
- Gas Blending
- Hypoxia
- Multipoint Gas Calibration