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The nutrient sensor OGT in PVN neurons regulates feeding
Olof Lagerlöf, Julia E. Slocomb, Ingie Hong, Yeka Aponte, Seth Blackshaw, Gerald W. Hart, Richard L. Huganir
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Protection against High-Fat-Diet-Induced Obesity in MDM2C305F Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure
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Cell Reports, Volume 18, Issue 4, p1005–1018, 24 January 2017
Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat
Philip M. Coan, Oliver Hummel, Ana Garcia Diaz, Marjorie Barrier, Neza Alfazema, Penny J. Norsworthy, Michal Pravenec, Enrico Petretto, Norbert Hübner, Timothy J. Aitman
Disease Models & Mechanisms 2017 10: 297-306; doi: 10.1242/dmm.026716
A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes
Lingling Shu, Ruby L. C. Hoo, Xiaoping Wu, Yong Pan, Ida P. C. Lee, Lai Yee Cheong, Stefan R Bornstein, Xianglu Rong, Jiao Guo & Aimin Xu
Nature Communications 8, Article number: 14147 (2017)
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Deletion of p22phox-dependent oxidative stress in the hypothalamus protects against obesity by modulating ß3 - adrenergic mechanisms
Heinrich E. Lob, Jiunn Song, Chansol Hurr, Alvin Chung, Colin N. Young, Allyn L. Mark, and Robin L. Davisson
JCI Insight. 2017;2(2):e87094.
Knocking down amygdalar PTP1B in diet-induced obese rats improves insulin signaling/action, decreases adiposity and may alter anxiety behavior
Natalia Ferreira Mendes, Gisele Castro, Dioze Guadagnini, Natalia Tobar, Susana Quiros Cognuck, Lucila Leico Kagohara Elias, Patricia Aline Boer, Patricia Oliveira Prada
Metabolism, Volume 70, May 2017, Pages 1–11
Pharmacological Inhibition of c-Jun N-terminal Kinase Reduces Food Intake and Sensitizes Leptin’s Anorectic Signaling Actions
Su Gao, Shannon Howard & Philip V. LoGrasso
Scientific Reports 7, Article number: 41795 (2017), doi:10.1038/srep41795
FAK signalling controls insulin sensitivity through regulation of adipocyte survival
Cynthia T. Luk, Sally Yu Shi, Erica P. Cai, Tharini Sivasubramaniyam, Mansa Krishnamurthy, Jara J. Brunt, Stephanie A. Schroer, Daniel A. Winer & Minna Woo
Nature Communications 8, Article number: 14360 (2017), doi:10.1038/ncomms14360
EPRS is a critical mTORC1–S6K1 effector that influences adiposity in mice
Abul Arif, Fulvia Terenzi, Alka A. Potdar, Jie Jia, Jessica Sacks, Arnab China, Dalia Halawani, Kommireddy Vasu, Xiaoxia Li, J. Mark Brown, Jie Chen, Sara C. Kozma, George Thomas & Paul L. Fox
Nature 542, 357–361 (16 February 2017), doi:10.1038/nature21380
17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization
Michael B. Stout, 1 Frederik J. Steyn, 2 Michael J. Jurczak, 3 Joao-Paulo G. Camporez, 4 Yi Zhu, 1 John R. Hawse, 5 Diana Jurk, 6 Allyson K. Palmer, 1 Ming Xu, Tamar Pirtskhalava, Glenda L. Evans, Roberta de Souza Santos, Aaron P. Frank, Thomas A. White, David G. Monroe, Ravinder J. Singh, Grace Casaclang-Verzosa, Jordan D. Miller, Deborah J. Clegg, Nathan K. LeBrasseur, Thomas von Zglinicki, Gerald I. Shulman, Tamara Tchkonia, and James L. Kirkland
J Gerontol A Biol Sci Med Sci. 2017 January; 72(1): 3–15. Published online 2016 January 24. doi:10.1093/gerona/glv309
RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs
Jiexin Wang, Prashant Rajbhandari, Andrey Damianov, Areum Han, Tamer Sallam, Hironori Waki, Claudio J. Villanueva, Stephen D. Lee, Ronni Nielsen, Susanne Mandrup, Karen Reue, Stephen G. Young, Julian Whitelegge, Enrique Saez, Douglas L. Black, and Peter Tontonoz
J Clin Invest. 2017;127(3):987-1004. doi:10.1172/JCI89484.
Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice
Naoto Nagata, Liang Xu, Susumu Kohno, Yusuke Ushida, Yudai Aoki, Ryohei Umeda, Nobuo Fuke, Fen Zhuge, Yinhua Ni, Mayumi Nagashimada, Chiaki Takahashi, Hiroyuki Suganuma, Shuichi Kaneko and Tsuguhito Ota
Diabetes 2017 Feb; db160662. https://doi.org/10.2337/db16-0662
An ATF4/ATG5 Signaling in Hypothalamic POMC Neurons Regulates Fat Mass via Affecting Energy Expenditure
Yuzhong Xiao, Yalan Deng, Feixiang Yuan, Tingting Xia, Hao Liu, Zhigang Li, Zhixue Liu, Hao Ying, Yi Liu, Qiwei Zhai, Shanghai Chen and Feifan Guo
Diabetes 2017 Feb; db161546. https://doi.org/10.2337/db16-1546
Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle
Sofi G. Julien , Sun-Yee Kim , Reinhard Brunmeir, Joanna R. Sinnakannu, Xiaojia Ge, Hongyu Li, Wei Ma, Jadegoud Yaligar, Bhanu Prakash KN, Sendhil S. Velan, Pia V. Röder, Qiongyi Zhang, Choon Kiat Sim, Jingyi Wu, Marta Garcia-Miralles, Mahmoud A. Pouladi, Wei Xie, Craig McFarlane, Weiping Han, Feng Xu
PLOS ONE: Biology, Published: February 16, 2017 https://doi.org/10.1371/journal.pbio.1002597
Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease
Faisal J. Alibhai, Jonathan LaMarre, Cristine J. Reitz, Elena V. Tsimakouridze, Jeffrey T. Kroetsch, Steffen-Sebastian Bolz, Alex Shulman, Samantha Steinberg, Thomas P. Burris, Gavin Y. Oudit
Journal of Molecular and Cellular Cardiology, Volume 105, April 2017, Pages 24–37
Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity
Ryan M. Morrow, Martin Picard, Olga Derbeneva, Jeremy Leipzig, Meagan J. McManus, Gilles Gouspillou, Sébastien Barbat-Artigas, Carlos Dos Santos, Russell T. Hepple, Deborah G. Murdock, and Douglas C. Wallace
PNAS, March 7, 2017 vol. 114 no. 10
Activation of murine pre-proglucagon–producing neurons reduces food intake and body weight
Ronald P. Gaykema, Brandon A. Newmyer, Matteo Ottolini, Vidisha Raje, Daniel M. Warthen, Philip S. Lambeth, Maria Niccum, Ting Yao, Yiru Huang, Ira G. Schulman, Thurl E. Harris, Manoj K. Patel, Kevin W. Williams, and Michael M. Scott
J Clin Invest. 2017;127(3):1031-1045. doi:10.1172/JCI81335.
Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain
Jo E. Lewis, John M. Brameld, Phil Hill, Cristina Cocco, Barbara Noli, Gian-Luca Ferri, Perry Barrett, Francis J. P. Ebling, Preeti H. Jethwa
PLOS ONE, Published: February 24, 2017 https://doi.org/10.1371/journal.pone.0172724
Time-restricted feeding on weekdays restricts weight gain: A study using rat models of high-fat diet-induced obesity
Magnus Kringstad Olsen, Man Hung Choi, Bard Kulseng, Chun-Mei Zhao, Duan Chen
Physiology & Behavior, Volume 173, 1 May 2017, Pages 298–304
Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice
Genevieve A. Bella, Debra Ann Fadool
Physiology & Behavior
Volume 174, 15 May 2017, Pages 104–113
β-Cell Inactivation of Gpr119 Unmasks Incretin-Dependence of GPR119-Mediated Glucoregulation
Brandon L. Panaro, Grace B. Flock, Jonathan E. Campbell, Jacqueline L. Beaudry, Xiemin Cao and Daniel J. Drucker
Diabetes 2017 Mar; db170017. https://doi.org/10.2337/db17-0017
Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice
Val A. Fajardo, Daniel Gamu, Andrew Mitchell, Darin Bloemberg, Eric Bombardier, Paige J. Chambers, Catherine Bellissimo, Joe Quadrilatero, A. Russell Tupling
PLOS ONE, Published: March 9, 2017
TFE3 regulates whole-body energy metabolism in cooperation with TFEB
Nunzia Pastore, Anna Vainshtein, Tiemo J Klisch, Andrea Armani, Tuong Huynh, Niculin J Herz, Elena V Polishchuk, Marco Sandri, View ORCID ProfileAndrea Ballabio
EMBO Molecular Medicine (2017) e201607204
Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning
Mallikarjun Patil, Bal Krishan Sharma, Sawsan Elattar, Judith Chang, Shweta Kapil, Jinling Yuan and Ande Satyanarayana
Diabetes 2017 Jun; 66(6): 1611-1625.
Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in ß-adrenergic receptor signaling.
Carroll SH, Zhang E, Wang BF, LeClair KB, Rahman A, Cohen DE, Plutzky J, Patwari P, Lee RT
PLoS One. 2017 Mar 14;12(3):e0173823. doi: 10.1371/journal.pone.0173823
Effects of hepatic glycogen on food intake and glucose homeostasis are mediated by the vagus nerve in mice
Iliana López-SoldadoRebeca Fuentes-RomeroJordi DuranJoan J. Guinovart
Diabetologia, June 2017, Volume 60, Issue 6, pp 1076–1083
pNaKtide Attenuates Steatohepatitis and Atherosclerosis by Blocking Na/K-ATPase/ROS Amplification in C57Bl6 and ApoE Knockout Mice Fed a Western Diet
Komal Sodhi, Krithika Srikanthan, Perrine Goguet-Rubio, Alexandra Nichols, Amrita Mallick, Athar Nawab, Rebecca Martin, Preeya T. Shah, Muhammad Chaudhry, Saroj Sigdel, Mehiar El-Hamdani, Jiang Liu, Zijian Xie, Nader G. Abraham & Joseph I. Shapiro
Scientific Reports 7, Article number: 193 (2017), doi:10.1038/s41598-017-00306-5
CL 316, 243 mediated reductions in blood glucose are enhanced in RIP140-/- mice independent of alterations in lipolysis
Willem T. Peppler, Paula M. Miotto, Graham P. Holloway, David C. Wright
Biochemical and Biophysical Research Communications, Volume 486, Issue 2, 29 April 2017, Pages 486–491
The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss
Zhiwei Zhang, Yae Hu, Ruhong Yan, Liang Dong, Yizhi Jiang, Zhichao Zhou, Meng Liu, Tiantian Zhou, Ningzheng Dong & Qingyu Wu
Scientific Reports 7, Article number: 45262 (2017)
A chemical chaperone improves muscle function in mice with a RyR1 mutation
Chang Seok Lee, Amy D. Hanna, Hui Wang, Adan Dagnino-Acosta, Aditya D. Joshi, Mark Knoblauch, Yan Xia, Dimitra K. Georgiou, Jianjun Xu, Cheng Long, Hisayuki Amano, Corey Reynolds, Keke Dong, John C. Martin, William R. Lagor, George G. Rodney, Ergun Sahin, Caroline Sewry & Susan L. Hamilton
Nature Communications 8, Article number: 14659 (2017), doi:10.1038/ncomms14659
Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20
Gan Liu, Luting Zhou, Hai Zhang, Rong Chen, Ye Zhang, Ling Li, Jun-Yu Lu, Hui Jiang, Dong Liu, Shasha Qi, Ying-Ming Jiang, Kai Yin, Zhifang Xie, Yuguang Shi, Yong Liu, Xuetao Cao, Yu-Xia Chen, Dajin Zou & Weiping J. Zhang
Nature Communications 8, Article number: 14824 (2017)
doi:10.1038/ncomms14824
Mfn2 is critical for brown adipose tissue thermogenic function
Marie Boutant, Sameer S Kulkarni, Magali Joffraud, Joanna Ratajczak, Miriam Valera-Alberni, Roy Combe, Antonio Zorzano, Carles Canto
The EMBO Journal (2017) e201694914
Maternal Retinoids Increase PDGFRα+ Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development
Bo Wang, Xing Fu, Xingwei Liang, Zhixiu Wang, Qiyuan Yang, Tiande Zou, Wei Nie, Junxing Zhao, Pengfei Gao, Mei-Jun Zhu, Jeanene M. de Avila, Joseph Maricelli, Buel D. Rodgers, Min Du
EBioMedicine 18 (2017) 288–299
Brazilian Green Propolis Promotes Weight Loss and Reduces Fat Accumulation in C57BL/6 Mice Fed A High-Fat Diet
Tohru Sakai, Miyuki Ohhata, Misaki Fujii, Sayaka Oda, Yasuna Kusaka, Miki Matsumoto, Akiko Nakamoto, Tomoyo Taki, Mariko Nakamoto, Emi Shuto
Biological and Pharmaceutical Bulletin, Vol. 40 (2017) No. 4 p. 391-395
p53-upregulated-modulatorof-apoptosis
(PUMA) deficiency
affects food intake but does not
impact on body weight or glucose
homeostasis in diet-induced
obesity
SaraA. Litwak, Kim Loh, William J. Stanley, EvanG. Pappas, JibranA.Wali, Claudia Selck, Andreas Strasser, Helen E.Thomas & Esteban N.Gurzov>br />Scientific Reports | 6:23802 | DOI: 10.1038/srep23802
Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ
Hua Mao, Pamela Lockyer, Luge Li, Christie M. Ballantyne, Cam Patterson, Liang Xie & Xinchun Pi
Nature Communications 8, Article number: 14960 (2017), doi:10.1038/ncomms14960
Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-Β oligomers in mice
Grasielle C. Kincheski, Isabela S. Valentim, Julia R. Clarke, Danielle Cozachenco, Morgana T.L. Castelo-Branco, Angela M. Ramos-Lobo, Vivian M.B.D. Rumjanek, José Donato Jr., Fernanda G. De Felice, Sergio T. Ferreira
Brain, Behavior, and Immunity, Volume 64, August 2017, Pages 140-151
Dietary lactalbumin and lactoferrin interact with inulin to modulate energy balance in obese rats
Arashdeep Singh, Rizaldy C. Zapata, Adel Pezeshki, Prasanth K. Chelikani
Obesity, Volume 25, Issue 6, June 2017, Pages 1050–1060
Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism
Gustaf Wigerblad, Duygu B Bas, Cátia Fernades-Cerqueira, Akilan Krishnamurthy, Kutty Selva Nandakumar, Katarzyna Rogoz, Jungo Kato, Katalin Sandor, Jie Su, Juan Miguel Jimenez-Andrade, Anja Finn, Alex Bersellini Farinotti, Khaled Amara, Karin Lundberg, Rikard Holmdahl, Per-Johan Jakobsson, Vivianne Malmström, Anca I Catrina, Lars Klareskog, Camilla I Svensson
Annals of the Rheumatic Diseases, 27 November 2015
Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice that is Dependent on Central Histamine H1 Receptors
Jesse Lea Carlin, Dilip K Tosh, Cuiying Xiao, Ramon A Pinol, Zhoumou Chen, Daniela Salvemini, Oksana Gavrilova, Kenneth A Jacobson, Marc L Reitman
The Journal of Pharmacology and Experimental Theraputics, 25 November 2015
Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis
Maria Razzoli, Andrea Frontini, Allison Gurney, Eleonora Mondini, Cankut Cubuk, Liora S. Katz, Cheryl Cero, Patrick J. Bolan, Joaquin Dopazo, Antonio Vidal-Puig, Saverio Cinti, Alessandro Bartolomucci
Molecular Metabolism, 11 November 2015
Citrus flavonoid, naringenin, increases locomotor activity and reduces diacylglycerol accumulation in skeletal muscle of obese ovariectomized mice
Jia-Yu Ke, Rachel M Cole, Essam M Hamad, Yung-Hsuan Hsiao, Bradley M Cotten, Kimerly A Powell, Martha A Belury
Molecular Nutrition & Food Research, 17 November 2015
Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance
Alexander M. Skeldon, Alexandre Morizot, Todd Douglas, Nicola Santoro, Romy Kursawe, Julia Kozlitina, Sonia Caprio, Wajahat Z. Mehal, Maya Saleh
The Journal of Immunology, 18 November 2015
Depletion of fat-resident Treg cells prevents age-associated insulin resistance
Sagar P. Bapat, Jae Myoung Suh, Sungsoon Fang, Sihao Liu, Yang Zhang, Albert Cheng, Carmen Zhou, Yuqiong Liang, Mathias LeBlanc, Christopher Liddle, Annette R. Atkins, Ruth T. Yu, Michael Downes, Ronald M. Evans, Ye Zheng
Nature, Vol. 528, Pages 137-141, 18 November 2015
Role of GABA Release From Leptin Receptor-Expressing Neurons in Body Weight Regulation
Yuanzhong Xu, William G. O'Brien III, Cheng-Chi Lee, Martin G. Myers Jr. and Qingchun Tong
Endocrinology May 1, 2012 vol. 153 no. 5 2223-2233
Deletion of protein tyrosine phosphatase 1b in proopiomelanocortin neurons reduces neurogenic control of blood pressure and protects mice from leptin- and sympatho-mediated hypertension
Thiago Bruder-Nascimento, Benjamin R. Butler, David J. Herren, Michael W. Brands, Kendra K. Bence, Eric J. Belin de Chantemèle
Pharmacological Research, 30 October 2015
Signaling through Tyr985 of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance
Jia You, Yue Yu, Lei Jiang, Wenxia Li, Xinxin Yu, Lety Gonzalez, Guoqing Yang,,Zunji Ke, Wenjun Li, Cai Li, and Yong Liu
Mol. Cell. Biol. 30 (7): 1650-1659
Carbohydrate Metabolism Is Perturbed in Peroxisome-deficient Hepatocytes Due to Mitochondrial Dysfunction, AMP-activated Protein Kinase (AMPK) Activation, and Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Suppression*
Annelies Peeters, Peter Fraisl, Sjoerd van den Berg?, Emiel Ver Loren van Themaat, Antoine Van Kampen, Mark H. Rider, Hiroshi Takemori, Ko Willems van Dijk, Paul P. Van Veldhoven, Peter Carmeliet and Myriam Baes
December 9, 2011 The Journal of Biological Chemistry, 286, 42162-42179.
Skeletal muscle AMP-activated protein kinase γ1H151R overexpression enhances whole body energy homeostasis and insulin sensitivity
Milena Schönke, Martin G. Myers Jr., Juleen R. Zierath, Marie Björnholm
American Journal of Physiology - Endocrinology and Metabolism, 25 August 2015
Genetic Regulation of Life Span, Metabolism, and Body Weight in Pohn, a New Wild-Derived Mouse Strain
Rong Yuan, Kevin Flurkey, Qingying Meng, Mike C. Astle and David E. Harrison
J Gerontol A Biol Sci Med Sci (2012)
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Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3
Huating Li, Zhanguo Gao, Jin Zhang, Xin Ye, Aimin Xu, Jianping Ye and Weiping Jia
Diabetes April 2012 vol. 61 no. 4 797-806
Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance
R. Palanivel, M. D. Fullerton, S. Galic, J. Honeyman, K. A. Hewitt, S. B. Jorgensen, G. R. Steinberg
Diabetologia
November 2012, Volume 55, Issue 11, pp 3083-3093
Identification of Body Fat Mass as a Major Determinant of Metabolic Rate in Mice
Karl J. Kaiyala, Gregory J. Morton, Brian G. Leroux, Kayoko Ogimoto, Brent Wisse and Michael W. Schwartz
Diabetes July 2010 vol. 59 no. 7 1657-1666
Quantitative analysis of light-phase restricted feeding reveals metabolic dyssynchrony in mice
M S Bray, W F Ratcliffe, M H Grenett, R A Brewer, K L Gamble and M E Young
International Journal of Obesity advance online publication 21 August 2012; doi: 10.1038/ijo.2012.137
Irisin: A myokine with locomotor activity
Weizhen Zhang, Lin Chang, Chao Zhang, Ruthann Zhang, Ziru Li, Biaoxin Chai, Jiyao Li, Eugene Chen, Michael Mulholland
Neuroscience Letters, 1 April 2015
Anti-Obesity Effects of Androgens,
Dehydroepiandrosterone (DHEA) and Testosterone
Kazuo Kajita, Ichiro Mori, Masahiro, Takahide Ikeda, Hiroyuki Morita and Tatsuo Ishizuka
Treatment of Type 2 Diabetes, Chapter 12, p295-312, April 2015
http://dx.doi.org/10.5772/59604
In vivo structure-function studies of human hepatic lipase: the catalytic function rescues the lean phenotype of HL-deficient (hl-/-) mice
Jeffrey Chen , Karl J. Kaiyala , Jennifer Lam , Nalini Agrawal , Lisa Nguyen , Kayoko Ogimoto , Dean Spencer , Gregory J. Morton , Michael W. Schwartz , Helen L. Dichek
Physiological Reports Published 10 April 2015 Vol. 3 no. e12365 DOI: 10.14814/phy2.12365
Differences in Hematopoietic Stem Cells Contribute to Sexually Dimorphic Inflammatory Responses to High Fat Diet Induced Obesity
Kanakadurga Singer, Nidhi Maley, Taleen Mergian, Jennifer DelProposto, Kae Won Cho, Brian F. Zamarron, Gabriel Martinez-Santibanez, Lynn Geletka, Lindsey Muir, Phillip Wachowiak, Chaghig Demirjian and Carey N. Lumeng
The Journal of Biological Chemistry, April 13, 2015, doi: 10.1074/jbc.M114.634568
Regulation of systemic energy homeostasis by serotonin in adipose tissues
Chang-Myung Oh, Jun Namkung, Younghoon Go, Ko Eun Shong, Kyuho Kim, Hyeongseok Kim, Bo-Yoon Park, Ho Won Lee, Yong Hyun Jeon, Junghan Song, Minho Shong, Vijay K. Yadav, Gerard Karsenty, Shingo Kajimura, In-Kyu Lee, Sangkyu Park & Hail Kim
Nature Communications 6, April 13, 2015, Article number: 6794 doi:10.1038/ncomms7794
Sarcolipin overexpression improves muscle energetics and reduces fatigue
Danesh H. Sopariwala , Meghna Pant , Sana A. Shaikh , Sanjeewa A. Goonasekera , Jeffery D. Molkentin , Noah Weisleder , Jianjie Ma , Zui Pan , Muthu Periasamy
Journal of Applied Physiology Published 15 April 2015 Vol. 118 no. 8, 1050-1058 DOI: 10.1152/japplphysiol.01066.2014
A novel CCK-8/GLP-1 hybrid peptide exhibiting prominent insulinotropic, glucose-lowering and satiety actions with significant therapeutic potential in high-fat fed mice
Nigel Irwin, Varun Pathak and Peter R. Flatt
Diabetes April 16, 2015
Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue
Murielle M. Véniant, Glenn Sivits, Joan Helmering, Renee Komorowski, Jae Lee, Wei Fan, Carolyn Moyer, David J. Lloyd
Cell Metabolism, Volume 21, Issue 5, 5 May 2015, Pages 731-738
Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1
Ricardo J. Samms, Dennis P. Smith, Christine C. Cheng, Patrick P. Antonellis, James W. Perfield 2nd, Alexei Kharitonenkov, Ruth E. Gimeno, Andrew C. Adams
Cell Reports, 5 May 2015
Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis
Brian T. O'Neill, Hans P.M.M. Lauritzen, Michael F. Hirshman, Graham Smyth, Laurie J. Goodyear, C. Ronald Kahn
Cell Reports, 14 May 2015
Treatment of Obesity with Celastrol
Junli Liu, Jaemin Lee, Mario Andres Salazar Hernandez, Ralph Mazitschek, Umut Ozcan
Cell, Vol. 161, Issue 5, p999-1011, 21 May, 2015
Matrix assisted transplantation of functional beige adipose tissue
Kevin M. Tharp, Amit K. Jha, Judith Kraiczy, Alexandra Yesian, Grigory Karateev, Riccardo Sinisi, Elena A. Dubikovskaya, Kevin E. Healy, Andreas Stahl
Diabetes, 20 August 2015
Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility
Shian-Huey Chiang, W. Wallace Harrington, Guizhen Luo, Naphtali O. Milliken, John C. Ulrich, Jing Chen, Deepak K. Rajpal, Ying Qian, Tiffany Carpenter, Rusty Murray, Robert S. Geske, Stephen A. Stimpson, Henning F. Kramer, Andrew N. Billin
PLOS One, 19 August 2015
Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes
Y.-S. Lee, M.-S. Park, J.-S. Choung, S.-S. Kim, H.-H. Oh, C.-S. Choi, S.-Y. Ha, Y. Kang, Y. Kim, H.-S. Jun
Diabetologia
September 2012, Volume 55, Issue 9, pp 2456-2468
META060 protects against diet-induced obesity and insulin resistance in a high-fat–diet fed mouse
Irene O.C.M. Vroegrijk, M.Sc., Janna A. van Diepen, M.Sc., Sjoerd A.A. van den Berg, Ph.D., Johannes A. Romijn, M.D., Ph.D., Louis M. Havekes, Ph.D., Ko Willems van Dijk, Ph.D., Gary Darland, Ph.D., Veera Konda, Ph.D., Matthew L. Tripp, Ph.D., Jeffrey S. Bland, Ph.D., Peter J. Vosho, Ph.D.
Nutrition
Volume 29, Issue 1, January 2013, Pages 276-283
A potential role for Insulin resistance in experimental pulmonary hypertension
James West, Kevin D. Niswender, Jennifer A. Johnson, Meredith E. Pugh, Linda Gleaves, Joshua P. Fessel and Anna R. Hemnes
ERJ August 30, 2012 erj00303-2012
Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased ER stress
Stanley MH Chan, Ruo-Qiong Sun, Xiao-Yi Zeng, Zi-Heng Choong, Hao Wang, Matthew J Watt and Ji-Ming Ye
Diabetes January 24, 2013, doi: 10.2337/db12-1397
Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle
P. Lau, R. L. Fitzsimmons, M. A. Pearen, M. J. Watt, G. E. O. Muscat
Diabetologia
May 2011, Volume 54, Issue 5, pp 1169-1180
Intracerebroventricular administration of vasoactive intestinal peptide inhibits food intake
Samar Ghourab , Kylie E. Beale , Nina M. Semjonous , Katherine A. Simpson , Niamh M. Martin , Mohammad A. Ghatei , Stephen R. Bloom, , Kirsty L. Smith
Regulatory Peptides
Volume 172, Issues 1-3, 10 December 2011, Pages 8-15
Adropin deficiency is associated with increased adiposity and insulin resistance.
Ganesh Kumar K, Zhang J, Gao S, Rossi J, McGuinness OP, Halem HH, Culler MD, Mynatt RL, Butler AA
Obesity (Silver Spring). 2012 Jul;20(7):1394-402. doi: 10.1038/oby.2012.31. Epub 2012 Feb 9.
Perinatal bisphenol A exposure promotes hyperactivity, lean body composition, and hormonal responses across the murine life course
Olivia S. Anderson, Karen E. Peterson, Brisa N. Sanchez, Zhenzhen Zhang, Peter Mancuso and Dana C. Dolinoy
FASEB J fj.12-223545; published ahead of print January 23, 2013
Kappa Opioid Receptor-Mediated Disruption of Novel Object Recognition: Relevance for Psychostimulant Treatment
Jason J. Paris, Kate J. Reilley, and Jay P. McLaughlin
J Addict Res Ther. 2011; S4: 007.
Increased Responses to the Actions of Fibroblast Growth Factor 21 on Energy Balance and Body Weight in a Seasonal Model of Adiposity
M. Murphy, R. Samms, A. Warner, M. Bolborea, P. Barrett, M. J. Fowler, J. M. Brameld, K. Tsintzas, A. Kharitonenkov, A. C. Adams, T. Coskun, F. J. P. Ebling
Journal of Neuroendocrinology
Volume 25, Issue 2, pages 180-189, February 2013
Intracerebroventricular Leptin Infusion Improves Glucose Homeostasis in Lean Type 2 Diabetic MKR Mice via Hepatic Vagal and Non-Vagal Mechanisms
Xiaosong Li, Xhiping Wu, Raul Camacho, Gary J. Schwartz, Derek LeRoith
PLoS ONE 6(2): e17058. doi:10.1371/journal.pone.0017058
A role for BDNF/TrkB signaling in behavioral and physiological consequences of social defeat stress
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ALCAR Exerts Neuroprotective and Pro-Neurogenic Effects by Inhibition of Glial Activation and Oxidative Stress via Activation of the Wnt/β-Catenin Signaling in Parkinsonian Rats
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Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production
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Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function
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Amitriptyline Improves Motor Function via Enhanced Neurotrophin Signaling and Mitochondrial Functions in the Murine N171-82Q Huntington's Disease Model
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A Novel Role for Subcutaneous Adipose Tissue in Exercise-Induced Improvements in Glucose Homeostasis
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Resveratrol restores the circadian rhythmic disorder of lipid metabolism induced by high-fat-diet in mice
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Monoclonal Antibody Targeting of Fibroblast Growth Factor Receptor 1c Ameliorates Obesity and Glucose Intolerance via Central Mechanisms
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Amitriptyline Improves Motor Function via Enhanced Neurotrophin Signaling and Mitochondrial Functions in the Murine N171-82Q Huntington's Disease Model
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Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function
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Interleukin-15 Modulates Adipose Tissue by Altering Mitochondrial Mass and Activity
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Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
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Leptin Resistance Is Not the Primary Cause of Weight Gain Associated With Reduced Sex Hormone Levels in Female Mice
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Coinhibitory Suppression of T Cell Activation by CD40 Protects Against Obesity and Adipose Tissue Inflammation in Mice
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Central IKKβ Inhibition Prevents Air Pollution Mediated Peripheral Inflammation and Exaggeration of Type II Diabetes
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A High-Fat Diet and NAD+ Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome
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Deletion of the gene encoding G0/G1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice
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A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome
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Hypermetabolism, Hyperphagia, and Reduced Adiposity in Tankyrase-Deficient Mice
Tsung-Yin J. Yeh, Kristina K. Beiswenger, Pingping Li, Krista E. Bolin, Ray M. Lee, Tsu-Shuen Tsao, Anne N. Murphy, Andrea L. Hevener and Nai-Wen Chi
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Suppressed cellular oscillations in After-hours mutant mice are associated with enhanced circadian phase-resetting
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Retinoid-related orphan receptor γ (RORγ) adult induced knockout mice develop lymphoblastic lymphoma
Maria Liljevald, Maria Rehnberg, Magnus Söderberg, Marie Ramnegård, Jenny Börjesson, Donatella Luciani, Nina Krutrök, Lena Brändén, Camilla Johansson, Xiufeng Xu, Mikael Bjursell, Anna-Karin Sjögren, Jorrit Hornberg, Ulf Andersson, David Keeling, Johan Jirholt
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Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice
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The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity
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Hepatocyte-specific Deletion of Janus Kinase 2 (JAK2) Protects against Diet-induced Steatohepatitis and Glucose Intolerance
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Delayed Puberty but Normal Fertility in Mice With Selective Deletion of Insulin Receptors From Kiss1 Cells
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Rhein Protects against Obesity and Related Metabolic Disorders through Liver X Receptor-Mediated Uncoupling Protein 1 Upregulation in Brown Adipose Tissue
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Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity
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Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation and atherosclerosis in Ldlr-/- mice
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Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice
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Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice
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L-Arginine promotes gut hormone release and reduces food intake in rodents
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Disruption of the sugar sensing receptor T1R2 attenuates metabolic derangements associated with diet-induced obesity
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Overexpression of β-klotho in adipose tissue sensitizes male mice to endogenous FGF21 and provides protection from diet-induced obesity
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Time-restricted feeding reduces adiposity in mice fed a high-fat diet
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Increased Gs Signaling in Osteoblasts Reduces Bone Marrow and Whole Body Adiposity in Male Mice
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Diet-induced obesity and insulin resistance are associated with brown fat degeneration in SIRT1-deficient mice
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Ptp1b Deletion In Pro-opiomelanocortin Neurons Increases Energy Expenditure And Impairs Endothelial Function Via TNF-α Dependent Mechanisms
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Ptp1b deletion in pro-opiomelanocortin neurons increases energy expenditure and impairs endothelial function via TNF-α dependent mechanisms
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Hepatic autophagy contributes to the metabolic response to dietary protein restriction
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The hypophagic response to heat stress is not mediated by GPR109A or peripheral β-OH butyrate
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miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity
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Normalization of Cardiac Substrate Utilization and Left Ventricular Hypertrophy Precede Functional Recovery in Heart Failure Regression
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Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways
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Electrophysiology and metabolism of caveolin-3-overexpressing mice
Jan M. Schilling , Yousuke T. Horikawa , Alice E. Zemljic-Harpf, Kevin P. Vincent, Leonid Tyan, Judith K. Yu, Andrew D. McCulloch, Ravi C. Balijepalli, Hemal H. Patel, David M. Roth
Basic Research in Cardiology, May 2016
Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes
Kanthi B. Krishna, Maja Stefanovic-Racic, Nikolaos Dedousis, Ian Sipula, Robert M. O'Doherty
Physiological Reports, Vol. 4, 31 March 2016
Maternal exercise during pregnancy promotes physical activity in adult offspring
Jesse D. Eclarinal, Shaoyu Zhu, Maria S. Baker, Danthasinghe B. Piyarathna, Cristian Coarfa, Marta L. Fiorotto, Robert A. Waterland
The FASEB Journal, 31 March 2016
p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity
Sara A. Litwak, Kim Loh, William J. Stanley, Evan G. Pappas, Jibran A. Wali, Claudia Selck, Andreas Strasser, Helen E. Thomas, Esteban N. Gurzov
Scientific Reports, Vol. 6, 1 April 2016
Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism
Kaisa M. Kettunen, Riitta Karikoski, Riikka H. Hämäläinen, Teija T. Toivonen, Vasily D. Antonenkov, Natalia Kulesskaya, Vootele Voikar, Maarit Hölttä-Vuori, Elina Ikonen, Kirsi Sainio, Anu Jalanko, Susann Karlberg, Niklas Karlberg, Marita Lipsanen-Nyman, Jorma Toppari, Matti Jauhiainen, J. Kalervo Hiltunen, Hannu Jalanko, Anna-Elina Lehesjoki
Biology Open, 2016
Mice Lacking Hepatic Lipase Are Lean and Protected against Diet-Induced Obesity and Hepatic Steatosis
Harvey K. Chiu, Kun Qian, Kayoko Ogimoto, Gregory J. Morton, Brent E. Wisse, Nalini Agrawal, Thomas O. McDonald, Michael W. Schwartz and Helén L. Dichek
Endocrinology Vol. 151, No. 3 993-1001
High levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity
Sjoerd AA van den Berg, Bruno Guigas, Silvia Bijland, Margriet Ouwens, Peter J Voshol, Rune R Frants, Louis M Havekes, Johannes A Romijn, Ko Willems van Dijk
Nutrition & Metabolism 2010, 7:24
The role of the NOP receptor in regulating food intake, meal pattern, and the excitability of proopiomelanocortin neurons
Borzoo Farhang, Lindsay Pietruszewski, Kabirullah Lutfy and Edward J. Wagner
Neuropharmacology Volume 59, Issue 3, September 2010, Pages 190-200
Subcutaneous oxyntomodulin analogue administration reduces body weight in lean and obese rodents
Y-L Liu, H E Ford, M R Druce, J S Minnion, B C T Field, J C Shillito, J Baxter, K G Murphy, M A Ghatei and S R Bloom
International Journal of Obesity 34, 1715-1725
In Vivo, Fatty Acid Translocase (CD36) Critically Regulates Skeletal Muscle Fuel Selection, Exercise Performance, and Training-induced Adaptation of Fatty Acid Oxidation
Jay T. McFarlan, Yuko Yoshida, Swati S. Jain, Xioa-Xia Han, Laelie A. Snook, James Lally, Brennan K. Smith, Jan F. C. Glatz, Joost J. F. P. Luiken, Ryan A. Sayer, A. Russell Tupling, Adrian Chabowski, Graham P. Holloway and Arend Bonen
July 6, 2012 The Journal of Biological Chemistry, 287, 23502-23516.
NT-PGC-1α Protein Is Sufficient to Link β3-Adrenergic Receptor Activation to Transcriptional and Physiological Components of Adaptive Thermogenesis*
Ji Suk Chang, Vivian Fernand, Yubin Zhang, Jeho Shin, Hee-Jin Jun, Yagini Joshi and Thomas W. Gettys
March 16, 2012 The Journal of Biological Chemistry, 287, 9100-9111.
Fasting Energy Homeostasis in Mice with Adipose Deficiency of Desnutrin/Adipose Triglyceride Lipase
Jiang Wei Wu, Shu Pei Wang, Stéphanie Casavant, Alain Moreau, Gong She Yang and Grant A. Mitchell
Endocrinology May 1, 2012 vol. 153 no. 5 2198-2207
Deletion of Muscle-enriched A-type Lamin-Interacting Protein (MLIP) leads to Cardiac Hyperactivation of Akt/mTOR and Impaired Cardiac Adaptation
Marie-Elodie Cattin, Jessica Wang, Jonathan J. Weldrick, Cassandra L. Roeske, Esther Mak, Stephanie L. Thorn, Jean N. DaSilva, Yibin Wang, Aldon J. Lusis, Patrick G. Burgon
The Journal of Biological Chemistry, 10 September 2015
The Hyperphagic Effect of Ghrelin Is Inhibited in Mice by a Diet High in Fat
James V. Gardiner, Daniel Campbell, Michael Patterson, Aysha Kent, Mohammed A. Ghatei, Stephen R. Bloom, Gavin A. Bewick
Gastroenterology Volume 138, Issue 7 , Pages 2468-2476.e1, June 2010
High-fat diets rich in medium- versus long-chain fatty acids induce distinct patterns of tissue specific insulin resistance
Johan De Vogel-van den Bosch, Sjoerd A.A. van den Berg, Silvia Bijland, Peter J. Voshol, Louis M. Havekes, Hans A. Romijn, Joris Hoeks, Denis van Beurden, Matthijs K.C. Hesselink, Patrick Schrauwenb and Ko Willems van Dijk
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Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice
Sergio Rodriguez-Cuenca, Helena M. Cochemé, Angela Logan, Irina Abakumova, Tracy A. Prime, Claudia Rose, Antonio Vidal-Puig, Anthony C. Smith, David C. Rubinsztein, Ian M. Fearnley, Bruce A. Jones, Simon Pope, Simon J.R. Heales, Brian Y.H. Lam, Sudeshna Guha Neogi, Ian McFarlane, Andrew M. James, Robin A.J. Smith and Michael P. Murphy
Free Radical Biology and Medicine
Volume 48, Issue 1, 1 January 2010, Pages 161-172
Leptin-Independent Programming of Adult Body Weight and Adiposity in Mice
Elizabeth C. Cottrell, Malgorzata S. Martin-Gronert, Denise S. Fernandez-Twinn, Jian'an Luan, Lindsey M. Berends and Susan E. Ozanne
Endocrinology Vol. 152, No. 2 476-482
Loss of polyubiquitin gene Ubb leads to metabolic and sleep abnormalities in mice
K.-Y. Ryu, N. Fujiki, M. Kazantzis, J. C. Garza, D. M. Bouley, A. Stahl, X.-Y. Lu, S. Nishino, R. R. Kopito
Neuropathology and Applied Neurobiology
Volume 36, Issue 4, pages 285-299, June 2010
Adenosine A2A Receptor Signaling and Golf Assembly Show a Specific Requirement for the {gamma}7 Subtype in the Striatum
William F. Schwindinger, Lauren J. Murphree Mihalcik, Kathryn E. Giger, Kelly S. Betz, Anna Maria Stauffer, Joel Linden, Denis Herve and Janet D. Robishaw
The Journal of Biological Chemistry, 285, 29787-29796.
Role of Peroxisome Proliferator-activated Receptor {delta/Beta} in Hepatic Metabolic Regulation
Sihao Liu, Ben Hatano, Minghui Zhao, Chen-Chung Yen, Kihwa Kang, Shannon M. Reilly, Matthew R. Gang, Cem Gorgun, James A. Balschi, James M. Ntambi and Chih-Hao Lee
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The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPAR{alpha}-Dependent Mechanisms
Jérôme N. Feige, Alan Gerber, Cristina Casals-Casas, Qian Yang, Carine Winkler, Elodie Bedu, Manuel Bueno, Laurent Gelman, Johan Auwerx, Frank J. Gonzalez, and Béatrice Desvergne
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Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue
Olivia Osborn, Manuel Sanchez-Alavez, Jeffrey S. Dubins, Alejandro Sanchez Gonzalez, Brad Morrison, John R. Hadcock, Tamas Bartfai
Cytokine
Volume 53, Issue 3, March 2011, Pages 311-319
Expression of Ankyrin Repeat and Suppressor of Cytokine Signaling Box Protein 4 (Asb-4) in Proopiomelanocortin Neurons of the Arcuate Nucleus of Mice Produces a Hyperphagic, Lean Phenotype
Ji-Yao Li, Biao-Xin Chai, Weizhen Zhang, Hui Wang and Michael W. Mulholland
Endocrinology January 1, 2010 vol. 151 no. 1 134-142
Leptin Action via Neurotensin Neurons Controls Orexin, the Mesolimbic Dopamine System and Energy Balance
Gina M. Leinninger, Darren M. Opland, Young-Hwan Jo, Miro Faouzi, Lyndsay Christensen, Laura A. Cappellucci, Christopher J. Rhodes, Margaret E. Gnegy, Jill B. Becker, Emmanuel N. Pothos, Audrey F. Seasholtz, Robert C. Thompson, Martin G. Myers
Cell Metabolism, Volume 14, Issue 3, 313-323, 7 September 2011
Inflammasome is a central player in the induction of obesity and insulin resistance
Rinke Stienstra, Janna A. van Diepen, Cees J. Tacka Md. Hasan Zakic Frank L. van de Veerdonk, Deshani Perera, Geoffrey A. Neale, Guido J. Hooiveld, Anneke Hijmans, Irene Vroegrijk, Sjoerd van den Berg, Johannes Romijn, Patrick C. N. Rensen, Leo A. B. Joosten, Mihai G. Netea, and Thirumala-Devi Kanneganti
PNAS August 29, 2011
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity.
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Iron Overload and Diabetes Risk: A Shift From Glucose to Fatty Acid Oxidation and Increased Hepatic Glucose Production in a Mouse Model of Hereditary Hemochromatosis
Jingyu Huang, Deborah Jones, Bai Luo, Michael Sanderson, Jamie Soto, E. Dale Abel, Robert C. Cooksey and Donald A. McClain
Diabetes January 2011 vol. 60 no. 1 80-87
Energy expenditure and bone formation share a common sensitivity to AP-1 transcription in the hypothalamus
Glenn C Rowe, Vincent Vialou, Kazusa Sato, Hiroaki Saito, Min Yin, Thomas A Green, Sutada Lotinun, Marie Kveiborg, William C Horne, Eric J Nestler, Roland Baron
Journal of Bone and Mineral Research
Volume 27, Issue 8, pages 1649-1658, August 2012
MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling
Jae-Sung Yi, Jun Sub Park, Young-Mi Ham, Nga Nguyen, Na-Rae Lee, Jin Hong, Bong-Woo Kim, Hyun Lee, Chang-Seok Lee, Byung-Cheon Jeong, Hyun Kyu Song, Hana Cho, Yoon Ki Kim, Jae-Seon Lee, Kyong Soo Park, Haksub Shin, Inho Choi, Seung Hee Lee, Woo Jin Park, Shi-Young Park
Nature Communications 4, Article number: 2354 doi:10.1038/ncomms3354
Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling
Jeremie Boucher, Marcelo A. Mori, Kevin Y. Lee, Graham Smyth, Chong Wee Liew, Yazmin Macotela, Michael Rourk, Matthias Bluher, Steven J. Russell & C. Ronald Kahn
Nature Communications 3, Article number: 902 doi:10.1038/ncomms1905
Metabolic Characterization of a Sirt5 deficient mouse model
Jiujiu Yu, Sushabhan Sadhukhan, Lilia G. Noriega, Norman Moullan, Bin He
Scientific Reports 3, doi:10.1038/srep02806
Systemic administration of Follistatin288 increases muscle mass and reduces fat accumulation in mice
Samudra S. Gangopadhyay
Scientific Reports 3, doi:10.1038/srep02441
Fetal growth restriction promotes physical inactivity and obesity in female mice
M S Baker, G Li, J J Kohorst & R A Waterland
International Journal of Obesity doi:10.1038/ijo.2013.146
Metformin improves healthspan and lifespan in mice
Alejandro Martin-Montalvo, Evi M. Mercken, Sarah J. Mitchell, Hector H. Palacios, Patricia L. Mote
Nature Communications 4, doi:10.1038/ncomms3192
Mitonuclear protein imbalance as a conserved longevity mechanism
Riekelt H. Houtkooper, Laurent Mouchiroud, Dongryeol Ryu, Norman Moullan, Elena Katsyuba
Nature 497, 451-457 doi:10.1038/nature12188
Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance
Chong Wee Liew, Jeremie Boucher, Jit Kong Cheong, Cecile Vernochet, Ho-Jin Koh
Nature Medicine 19, 217-226 doi:10.1038/nm.3056
TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop
Carmine Settembre, Rossella De Cegli, Gelsomina Mansueto, Pradip K. Saha, Francesco Vetrini
Nature Cell Biology 15, 647-658 doi:10.1038/ncb2718
Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat
Tim J. Schulz, Ping Huang, Tian Lian Huang, Ruidan Xue, Lindsay E. McDougall
Nature 495, 379-383 doi:10.1038/nature11943
Motor neuron degeneration in a mouse model of seipinopathy
J Guo, W Qiu, S L Y Soh, S Wei, G K Radda
Cell Death and Disease 4, e535 doi:10.1038/cddis.2013.64
An inhibitor of the protein kinases TBK1 and IKK-? improves obesity-related metabolic dysfunctions in mice
Shannon M Reilly, Shian-Huey Chiang, Stuart J Decker, Louise Chang, Maeran Uhm
Nature Medicine 19, 313-321 doi:10.1038/nm.3082
Obesity in mice with adipocyte-specific deletion of clock component Arntl
Georgios K Paschos, Salam Ibrahim, Wen-Liang Song, Takeshige Kunieda, Gregory Grant
Nature Medicine 18, 1768-1777 doi:10.1038/nm.2979
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue
Florian W Kiefer, Cecile Vernochet, Patrick O'Brien, Steffen Spoerl, Jonathan D Brown
Nature Medicine 18, 918-925 doi:10.1038/nm.2757
Leptin action through hypothalamic nitric oxide synthase-1–expressing neurons controls energy balance
Rebecca L Leshan, Megan Greenwald-Yarnell, Christa M Patterson, Ian E Gonzalez & Martin G Myers
Nature Medicine 18, 820-823 doi:10.1038/nm.2724
Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
Daniel A Lee, Joseph L Bedont, Thomas Pak, Hong Wang, Juan Song
Nature Neuroscience 15, 700-702 doi:10.1038/nn.3079
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
Katja A. Lamia, Stephanie J. Papp, Ruth T. Yu, Grant D. Barish, N. Henriette Uhlenhaut
Nature 480, 552-556 doi:10.1038/nature10700
The metabolic footprint of aging in mice
Riekelt H. Houtkooper, Carmen Argmann, Sander M. Houten, Carles Cantó, Ellen H. Jeninga
Scientific Reports 1, doi:10.1038/srep00134
Interaction of MAGED1 with nuclear receptors affects circadian clock function
Xiaohan Wang, Jing Tang, Lijuan Xing, Guangsen Shi, Haibin Ruan
The EMBO Journal 29, 1389-1400 doi:10.1038/emboj.2010.34
ATF4 regulates lipid metabolism and thermogenesis
Chunxia Wang, Zhiying Huang, Ying Du, Ying Cheng, Shanghai Chen
Cell Research 20, 174-184 doi:10.1038/cr.2010.4
Single-cell transcriptomics and functional target validation of brown adipocytes show their complex roles in metabolic homeostasis
Jennifer M. Spaethling, Manuel Sanchez-Alavez, JaeHee Lee, Feng C. Xia, Hannah Dueck, Wenshan Wang, Stephen A. Fisher, Jai-Yoon Sul, Patrick Seale, Junhyong Kim, Tamas Bartfai, James Eberwine
The Journal of the Federation of American Societies for Experimental Biology, 24 August 2015
Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism
Kevin Y. Lee, Manvendra K. Singh, Siegfried Ussar, Petra Wetzel, Michael F. Hirshman, Laurie J. Goodyear, Andreas Kispert, C. Ronald Kahn
Nature Communications, Vol. 6, 24 August 2015
Adipocyte iron regulates leptin and food intake
Yan Gao, Zhonggang Li, J. Scott Gabrielsen, Judith A. Simcox, Soh-hyun Lee, Deborah Jones, Bob Cooksey, Gregory Stoddard, William T. Cefalu, Donald A. McClain
The Journal of Clinical Investigation, 24 August 2015
Dietary Whey and Casein Differentially Affect Energy Balance, Gut Hormones, Glucose Metabolism, and Taste Preference in Diet-Induced Obese Rats
Adel Pezeshki, Andrew Fahim, Prasanth K Chelikani
The Journal of Nutrition, 26 August 2015
Leptin Suppresses the Rewarding Effects of Running via STAT3 Signaling in Dopamine Neurons
Maria Fernanda A. Fernandes, Dominique Matthys, Cécile Hryhorczuk, Sandeep Sharma, Shabana Mogra, Thierry Alquier, Stephanie Fulton
Cell Metabolism, 1 September 2015
Pioglitazone treatment increases food intake and decreases energy expenditure partially via hypothalamic adiponectin/adipor1/ampk pathway
Alexandre Hilário Berenguer de Matos, Iscia Lopes-Cendes, Franco Folli, Patricia Prada
International Journal of Obesity, July 2015
Obesity resistance and increased energy expenditure by white adipose tissue browning in Oga +/- mice
Yong Ryoul Yang, Hyun-Jun Jang, Sun-Sil Choi, Yong Hwa Lee, Gyun Hui Lee, Young-Kyo Seo, Jang Hyun Choi, Dohyun Park, Ara Koh
Diabetologia, 5 September 2015
β-Catenin Links Hepatic Metabolic Zonation with Lipid Metabolism and Diet-Induced Obesity in Mice
Jaideep Behari, Huanan Li, Shiguang Liu, Maja Stefanovic-Racic, Laura Alonso, Christopher P. O'Donnell, Sruti Shiva, Srikanth Singamsetty, Yoshio Watanabe, Vijay P. Singh, Qing Liu
The American Journal of Pathology, 7 October 2014
Adipocyte-Specific Deletion of Manganese Superoxide Dismutase Protects from Diet-Induced Obesity Via Increased Mitochondrial Uncoupling and Biogenesis
Yong Hwan Han, Márcio Buffolo, Karla Maria Pires, Shaobo Pei, Philipp E. Scherer, Sihem Boudina
Diabetes, June 2016
The role of α1-adrenergic receptors in regulating metabolism: increased glucose tolerance, leptin secretion and lipid oxidation
Ting Shi, Robert S. Papay, Dianne M. Perez
Journal of Receptors and Signal Transduction, 8 June 2016
Systems proteomics of liver mitochondria function
Evan G. Williams, Yibo Wu, Pooja Jha, Sébastien Dubuis, Peter Blattmann, Carmen A. Argmann, Sander M. Houten, Tiffany Amariuta, Witold Wolski, Nicola Zamboni, Ruedi Aebersold, Johan Auwerx
Science, 10 June 2016
Thioesterase superfamily member 2/acyl-CoA thioesterase 13 (Them2/Acot13) regulates hepatic lipid and glucose metabolism
Hye Won Kang, Michele W. Niepel, Shuxin Han, Yuki Kawano and David E. Cohen
May 2012
The FASEB Journal
vol. 26 no. 5 2209-2221
Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation
Mirjam Langeveld, Sjoerd A.A. van den Berg, 1, Nora Bijl, Silvia Bijland, Cindy P. van Roomen, Judith H. Houben-Weerts, Roelof Ottenhoff, Sander M. Houten, Ko Willems van Dijk, Johannes A. Romijn, Albert K. Groen, Johannes M. Aerts, Peter J. Voshol
Metabolism
Volume 61, Issue 1, January 2012, Pages 99-107
Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity
Sebastian Beck Jorgensen, Hayley M. O’Neill, Lykke Sylow, Jane Honeyman, Kimberly A. Hewitt, Rengasamy Palanivel, Morgan D. Fullerton, Lisa Öberg, Anudharan Balendran, Sandra Galic, Chris van der Poel, Ian A. Trounce, Gordon S. Lynch, Jonathan D. Schertzer and Gregory R. Steinberg
Diabetes September 6, 2012
Ski overexpression in skeletal muscle modulates genetic programs that control susceptibility to diet-induced obesity and insulin signaling
Diaz, Marianne, Martel, Nick, Fitzsimmons, Rebecca L., Eriksson, Natalie A., Cowin, Gary J., Thomas, Gethin P., Le Cao, Kim-Anh, Muscat, George E. O. and Leong, Gary M
Obesity (Silver Spring). 2012 Nov;20(11):2157-67
Leptin potentiates the anti-obesity effects of rimonabant
Carine M. Boustany-Kari, V. Margaret Jackson, Colleen P. Gibbons, Andrew G. Swick
European Journal of Pharmacology
Volume 658, Issues 2-3, 11 May 2011, Pages 270-276
Constitutive Activation of IKKβ in Adipose Tissue Prevents Diet-Induced Obesity in Mice
Ping Jiao, Bin Feng, Jie Ma, Yaohui Nie, Erin Paul, Yujie Li and Haiyan Xu
Endocrinology January 1, 2012 vol. 153 no. 1 154-165
GRK5 deficiency decreases diet-induced obesity and adipogenesis
Feifei Wang, Li Wang, Minjie Shen, Lan Ma
Biochemical and Biophysical Research Communications
Volume 421, Issue 2, 4 May 2012, Pages 312-317
T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice
K. Loh, T. L. Merry, S. Galic, B. J. Wu, M. J. Watt, S. Zhang, Z.-Y. Zhang, B. G. Neel, T. Tiganis
Diabetologia
February 2012, Volume 55, Issue 2, pp 468-478
GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function
Tamas L. Horvath, Derek M. Erion, John D. Elsworth, Robert H. Roth, Gerald I. Shulman, Zane B. Andrews
Neurobiology of Disease
Volume 43, Issue 1, July 2011, Pages 152-162
Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: Implications for liver regeneration
Manuel Alejandro Fernández-Rojo, Christina Restall, Charles Ferguson, Nick Martel, Sally Martin, Marta Bosch, Adam Kassan, Gary M. Leong, Sheree D. Martin, Sean L. McGee, George E.O. Muscat, Robin L. Anderson, Carlos Enrich, Albert Pol, Robert G. Parton
Hepatology
Volume 55, Issue 5, pages 1574-1584, May 2012
Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease
Pengxiang She, Zhiyou Zhang, Deanna Marchionini, William C. Diaz, Thomas J. Jetton, Scot R. Kimball, Thomas C. Vary, Charles H. Lang, and Christopher J. Lynch
AJP - Endo July 1, 2011 vol. 301 no. 1 E49-E61
Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception
Lawrence Toll, Taline V. Khroyan, Kemal Sonmez, Akihiko Ozawa, Iris Lindberg, Jay P. McLaughlin, Shainnel O. Eans, Amir A. Shahien and Daniel R. Kapusta
February 2012
The FASEB Journal
vol. 26 no. 2 947-954
Oxygen Consumption, Muscle Fibrosis, and Oxidative Stress in the mdx mouse: Influence of Treadmill Running
Schill, Kevin E
OhioLINK
Glucocorticoids transcriptionally regulate miR-27b expression promoting body fat accumulation via suppressing the browning of white adipose tissue
Xiaocen Kong, Jing Yu, Jianhua Bi, Hanmei Qi, Wenjuan Di, Lin Wu, Long Wang, Juanmin Zha, Shan Lv, Feng Zhang, Yan Li, Fang Hu, Feng Liu, Hong Zhou, Juan Liu1 and Guoxian Ding
Diabetes September 3, 2014, doi: 10.2337/db14-0395
Adiponectin is not required for exercise training?induced improvements in glucose and insulin tolerance in mice
Ian R. W. Ritchie , David C. Wright , David J. Dyck
Physiological ReportsPublished 11 September 2014Vol. 2no. e12146 DOI: 10.14814/phy2.12146
Cardiomyocyte-Specific BMAL1 Plays Critical Roles in Metabolism, Signaling, and Maintenance of Contractile Function of the Heart
Martin E. Young, Rachel A. Brewer, Rodrigo A. Peliciari-Garcia, Helen E. Collins, Lan He, Tana L. Birky, Bradley W. Peden, Emily G. Thompson, Billy-Joe Ammons, Molly S. Bray, John C. Chatham, Adam R. Wende, Qinglin Yang, Chi-Wing Chow, Tami A. Martino, Karen L. Gamble
J Biol Rhythms August 2014 vol. 29 no. 4 257-276
Liver glycogen reduces food intake and attenuates obesity in a high-fat diet-fed mouse model
Iliana Lopez-Soldado, Delia Zafra, Jordi Duran, Anna Adrover, Joaquim Calbol and Joan J. Guinovart
Diabetes October 2, 2014
Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice
Hanlin Tao, Yong Zhang, Xiangang Zeng, Gerald I Shulman & Shengkan Jin
Nature Medicine (5 October 2014), doi:10.1038/nm.3699
Epigenetic dysregulation of the dopamine system in diet-induced obesity
Zivjena Vucetic, Jesse Lea Carlin, Kathy Totoki, Teresa M. Reyes
Journal of Neurochemistry
Volume 120, Issue 6, pages 891-898, March 2012
Atypical Protein Kinase C Activity in the Hypothalamus Is Required for Lipopolysaccharide-Mediated Sickness Responses
Joshua P. Thaler, Sun Ju Choi, Mini P. Sajan, Kayoko Ogimoto, Hong T. Nguyen, Miles Matsen, Stephen C. Benoit, Brent E. Wisse, Robert V. Farese and Michael W. Schwartz
Endocrinology December 1, 2009 vol. 150 no. 12 5362-5372
Neuropeptide Y and Agouti-Related Peptide Mediate Complementary Functions of Hyperphagia and Reduced Energy Expenditure in Leptin Receptor Deficiency
Na Luo, Genevieve Marcelin, Shun Mei Liu, Gary Schwartz and Streamson Chua Jr
Endocrinology March 1, 2011 vol. 152 no. 3 883-889
Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT
Ying Du, Qingshu Meng, Qian Zhang, Feifan Guo
Amino Acids
August 2012, Volume 43, Issue 2, pp 725-734
Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3β and mitochondrial function
Yingmei Zhang, Sara A Babcock, Nan Hu, Jacalyn R Maris, Haichang Wang and Jun Ren
BMC Medicine 2012, 10:40 doi:10.1186/1741-7015-10-40
SIRT1 Deacetylase in SF1 Neurons Protects against Metabolic Imbalance
Giorgio Ramadori, Teppei Fujikawa, Jason Anderson, Eric D. Berglund, Renata Frazao, Shaday Michan, Claudia R. Vianna, David A. Sinclair, Carol F. Elias, Roberto Coppari
Cell Metabolism, Volume 14, Issue 3, 7 September 2011, Pages 301-312
Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation
Caleb C. Lord, Daniel Ferguson, Gwynneth Thomas, Amanda L. Brown, , Rebecca C. Schugar, Amy Burrows, Anthony D. Gromovsky, Jenna Betters, Chase Neumann, Jessica Sacks, Stephanie Marshall, Russell Watts, Martina Schweiger, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, Justin D. Lathia, Takuya F. Sakaguchi, Richard Lehner, Guenter Haemmerle, Rudolf Zechner, J. Mark Brown
Cell Reports, Vol. 16, Issue 4, Pages 939-949, 26 July 2016
The combined effects on neuronal activation and blood–brain barrier permeability of time and n-3 polyunsaturated fatty acids in mice, as measured in vivo using MEMRI
Yu-Ting Kuo, Po-Wah Soc, James R. Parkinson, Wei Sheng Yu, Mohammad Hankir, Amy H. Herlihy, Anthony P. Goldstone, Gary S. Frost, Clive Wasserfall and Jimmy D. Bell
NeuroImage Volume 50, Issue 4, 1 May 2010, Pages 1384-1391
A Role of Erythrocytes in Adenosine Monophosphate Initiation of Hypometabolism in Mammals
Isadora Susan Daniels, Jianfa Zhang, William G. O'Brien III, Zhenyin Tao, Tomoko Miki, Zhaoyang Zhao, Michael R. Blackburn and Cheng Chi Lee
July 2, 2010 The Journal of Biological Chemistry, 285, 20716-20723
Insulin Causes Hyperthermia by Direct Inhibition of Warm-Sensitive Neurons
Manuel Sanchez-Alavez, Iustin V. Tabarean, Olivia Osborn, Kayo Mitsukawa, Jean Schaefer, Jeffrey Dubins, Kristina H. Holmberg, Izabella Klein, Joe Klaus, Luis F. Gomez, Hartmuth Kolb, James Secrest, Jeanine Jochems, Kevin Myashiro, Peter Buckley, John R. Hadcock, James Eberwine, Bruno Conti1 and Tamas Bartfai
Diabetes January 2010 vol. 59 no. 1 43-50
Characterization of the Hyperphagic Response to Dietary Fat in the MC4R Knockout Mouse
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Hepatic Oxidative Stress Promotes Insulin-STAT-5 Signaling and Obesity by Inactivating Protein Tyrosine Phosphatase N2
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Photoperiod Affects Organ Specific Glucose Metabolism in Male Siberian Hamsters (Phodopus sungorus)
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Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat
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Mice Lacking the Neuropeptide alpha-Calcitonin Gene-Related Peptide Are Protected Against Diet-Induced Obesity
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NOD1 Activators Link Innate Immunity to Insulin Resistance
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Butyrylcholinesterase Deficiency Promotes Adipose Tissue Growth and Hepatic Lipid Accumulation in Male Mice on High-Fat Diet
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TRPV1 Pain Receptors Regulate Longevity and Metabolism by Neuropeptide Signaling
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The Chemical Uncoupler 2,4-Dinitrophenol (DNP) Protects Against Diet-induced Obesity and Improves Energy Homeostasis in Mice at Thermoneutrality
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Retinaldehyde Dehydrogenase 1 Coordinates Hepatic Gluconeogenesis and Lipid Metabolism
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CrbpI Modulates Glucose Homeostasis and Pancreas 9-cis-Retinoic Acid Concentrations?
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Journal of Lipid Research, 7 July 2016
Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2
Thomas Laeger, Diana C. Albarado, Susan J. Burke, Lexus Trosclair, John W. Hedgepeth, Hans-Rudolf Berthoud, Thomas W. Gettys, J. Jason Collier, Heike Münzberg, Christopher D. Morrison
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Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism
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Hypoxia-Induced Intrauterine Growth Restriction Increases the Susceptibility of Rats to High-Fat Diet–Induced Metabolic Syndrome
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Diabetes February 2011 vol. 60 no. 2 507-516
Alterations in Skeletal Muscle Fatty Acid Handling Predisposes Middle-Aged Mice to Diet-Induced Insulin Resistance
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Early life protein restriction alters dopamine circuitry
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Short-Days Induce Weight Loss in Siberian Hamsters Despite Overexpression of the Agouti-Related Peptide Gene
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Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/– Mice: A Role of Lipid Mobilization and Inflammation
Fen Xu, Zhanguo Gao, Jin Zhang, Chantal A. Rivera, Jun Yin, Jianping Weng and Jianping Ye
Endocrinology Vol. 151, No. 6 2504-2514
Adipose Triglyceride Lipase-Null Mice Are Resistant to High-Fat Diet–Induced Insulin Resistance Despite Reduced Energy Expenditure and Ectopic Lipid Accumulation
Andrew J. Hoy, Clinton R. Bruce, Sarah M. Turpin, Alexander J. Morris, Mark A. Febbraio and Matthew J. Watt
Endocrinology Vol. 152, No. 1 48-58
The Proinflammatory Cytokine Interleukin 18 Regulates Feeding by Acting on the Bed Nucleus of the Stria Terminalis
Walter Francesconi, Manuel Sánchez-Alavez, Fulvia Berton, Silvia Alboni, Cristina Benatti, Simone Mori, William Nguyen, Eric Zorrilla, Gianluca Moroncini, Fabio Tascedda, Bruno Conti
The Journal of Neuroscience, 4 May 2016
Glutamatergic Preoptic Area Neurons That Express Leptin Receptors Drive Temperature-Dependent Body Weight Homeostasis
Sangho Yu, Emily Qualls-Creekmore, Kavon Rezai-Zadeh, Yanyan Jiang, Hans-Rudolf Berthoud, Christopher D. Morrison, Andrei V. Derbenev, Andrea Zsombok, Heike Münzberg
The Journal of Neuroscience, 4 May 2016
Cholesterol 7{alpha}-hydroxylase-deficient mice are protected from high fat/high cholesterol diet-induced metabolic disorders
Jessica M. Ferrell, Shannon Boehme, Feng Li, John Y. L. Chiang
Journal of Lipid Research, 4 May 2016
Effect of Selective Expression of Dominant Negative PPAR? in Proopiomelanocortin Neurons on the Control of Energy Balance
Madeliene Stump, Deng-Fu Guo, Ko-Ting Lu, Masashi Mukohda, Xuebo Liu, Kamal Rahmouni, Curt D. Sigmund
Physiological Genomics, 13 May 2016
MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics
Dhanendra Tomar11, Zhiwei Dong11, Santhanam Shanmughapriya11, Diana A. Koch11, Toby Thomas, Nicholas E. Hoffman, Shrishiv A. Timbalia, Samuel J. Goldman, Sarah L. Breves, Daniel P. Corbally, Neeharika Nemani, Joseph P. Fairweather, Allison R. Cutri, Xueqian Zhang, Jianliang Song, Fabián Jaña, Jianhe Huang, Carlos Barrero, Joseph E. Rabinowitz, Timothy S. Luongo, Sarah M. Schumacher, Michael E. Rockman, Alexander Dietrich, Salim Merali, Jeffrey Caplan, Peter Stathopulos, Rexford S. Ahima, Joseph Y. Cheung, Steven R. Houser, Walter J. Koch, Vickas Patel, Vishal M. Gohil, John W. Elrod, Sudarsan Rajan, Muniswamy Madesh
Cell Reports, 12 May 2016
Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms
Padmamalini Baskaran, Vivek Krishnan, Jun Ren, Baskaran Thyagarajan
British Journal of Pharmacology, 21 June 2016
Berardinelli-Seip Congenital Lipodystrophy 2 (BSCL2)/SEIPIN is not required for Brown Adipogenesis but Regulates Brown Adipose Tissue Development and Function
Hongyi Zhou, Stephen M. Black, Tyler W. Benson, Neal L. Weintraub, Weiqin Chen
Molecular and Cellular Biology, 16 May 2016
Remodeling of Hepatic Metabolism and Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides
Chika Watanabe, Yusuke Seino, Hiroki Miyahira, Michiyo Yamamoto, Ayako Fukami, Nobuaki Ozaki, Yoshiko Takagishi, Jun Sato, Tsutomu Fukuwatari, Katsumi Shibata, Yutaka Oiso, Yoshiharu Murata and Yoshitaka Hayashi
Diabetes January 2012 vol. 61 no. 1 74-84
Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in obese versus lean mice
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Fasting enriches liver triacylglycerol with n-3 polyunsaturated fatty acids: implications for understanding the adipose-liver axis in serum docosahexaenoic acid regulation
Kristin A. Marks, Phillip M. Marvyn, Juan J. A. Henao, Ryan M. Bradley, Ken D. Stark, Robin E. Duncan
Genes and Nutrition, November 2015
Eliciting the mitochondrial unfolded protein response via NAD+ repletion reverses fatty liver disease
Karim Gariani, Keir J. Menzies, Dongryeol Ryu, Casey J. Wegner, Xu Wang, Eduardo R. Ropelle, Norman Moullan, Hongbo Zhang, Alessia Perino, Vera Lemos, Bohkyung Kim, Young-Ki Park, Alessandra Piersigilli, Tho X. Pham, Yue Yang, Chai Siah Ku, Sung I. Koo, Anna Fomitchova, Carlos Cantó, Kristina Schoonjans, Anthony A. Sauve, Ji-Young Lee, Johan Auwerx
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Effect of genotype on heat production and net energy value of a corn-soybean meal-based diet fed to growing pigs
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Veterinarni Medicina, Vol. 60, Number 9, Pages 489-498, 2015
Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation
Paul J. Meakin, Vicky L. Morrison, Claire C. Sneddon, Terhi Savinko, Liisa Uotila, Susan M. Jalicy, Jennie L. Gabriel, Li Kang, Michael L. J. Ashford, Susanna C. Fagerholm
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Arylpiperazinylalkyl derivatives of 8-amino-1,3-dimethylpurine-2,6-dione as novel multitarget 5-HT/D receptor agents with potential antipsychotic activity
Grażyna Chłoń-Rzepa, Adam Bucki, Marcin Kołaczkowski, Anna Partyka, Magdalena Jastrzębska-Więsek, Grzegorz Satała, Andrzej J. Bojarski, Justyna Kalinowska-Tłuścik, Grzegorz Kazek, Barbara Mordyl, Monika Głuch-Lutwin, Anna Wesołowska
Journal of Enzyme Inhibition and Medicinal Chemistry, 25 September 2015
Reproduction and Growth in a Murine Model of Early Life-Onset Inflammatory Bowel Disease
Eniko Nagy, Ramona M. Rodriguiz, William C. Wetsel, Nancie J. MacIver, Laura P. Hale
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Effects of Long-Term Exposure to Free Nε-(Carboxymethyl)lysine on Rats Fed a High-Fat Diet
Mei Li, Maomao Zeng, Zhiyong He, Zongping Zheng, Fang Qin, Guanjun Tao, Shuang Zhang, Jie Chen
Journal of Agricultural and Food Chemistry, 11 December 2015
Direct High Throughput In Vivo Screening: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine bis-Piperazines
Richard A. Houghten, Michelle L. Ganno, Jay P. McLaughlin, Colette T. Dooley, Shainnel O. Eans, Radleigh G. Santos, Travis LaVoi, Adel Nefzi, Greg Welmaker, Marc A. Giulianotti, and Lawrence Toll
ACS Combinatorial Science, 10 December 2015
Disruption of the Circadian Output Molecule Prokineticin 2 Results in Anxiolytic and Antidepressant-like Effects in Mice
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Leptin Production by Encapsulated Adipocytes Increases Brown Fat, Decreases Resistin, and Improves Glucose Intolerance in Obese Mice
David J. DiSilvestro, Emiliano Melgar-Bermudez, Rumana Yasmeen, Paolo Fadda, L. James Lee, Anuradha Kalyanasundaram, Chen L. Gilor, Ouliana Ziouzenkova
PLOS One, 7 April 2016
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Society for Endocrinology, 20 April 2016
N-3 Polyunsaturated Fatty Acids Improve Liver Lipid Oxidation-Related Enzyme Levels and Increased the Peroxisome Proliferator-Activated Receptor α Expression Level in Mice Subjected to Hemorrhagic Shock/Resuscitation
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Clostridium Butyricum CGMCC0313.1 Modulates Lipid Profile, Insulin Resistance and Colon Homeostasis in Obese Mice
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α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes
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LACK OF cAMP RESPONSE ELEMENT BINDING PROTEIN (CREB1) IN THE
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The Role of Phosphatidylinositol-3-Kinase and AMP-Activated Kinase in the Rapid Estrogenic Attenuation of Cannabinoid-Induced Changes in Energy Homeostasis
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Type 2 Corticotropin-Releasing Factor Receptor in the Ventromedial Nucleus of Hypothalamus Is Critical in Regulating Feeding and Lipid Metabolism in White Adipose Tissue
Hongxia Chao, Michael Digruccio, Peilin Chen and Chien Li
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Chronic sleep restriction during development can lead to long-lasting behavioral effects
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Physiology & Behavior, 19 December 2015
A High-Fat, High-Oleic Diet, But Not a High-Fat, Saturated Diet, Reduces Hepatic α-Linolenic Acid and Eicosapentaenoic Acid Content in Mice
Matthew J. Picklo, Eric J. Murphy
Lipids, Pages 1-11, 22 December 2015
Defective PITRM1 mitochondrial peptidase is associated with Aβ amyloidotic neurodegeneration
Dario Brunetti, Janniche Torsvik, Cristina Dallabona, Pedro Teixeira, Pawel Sztromwasser, Erika Fernandez-Vizarra, Raffaele Cerutti, Aurelio Reyes, Carmela Preziuso, Giulia D'Amati, Enrico Baruffini, Paola Goffrini, Carlo Viscomi, Ileana Ferrero, Helge Boman, Wenche Telstad, Stefan Johansson, Elzbieta Glaser, Per M Knappskog, Massimo Zeviani, Laurence A Bindoff
EMBO Molecular Medicine, 23 December 2015
Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes
M. Furkan Burak, Karen E. Inouye, Ariel White, Alexandra Lee, Gurol Tuncman, Ediz S. Calay, Motohiro Sekiya, Amir Tirosh, Kosei Eguchi, Gabriel Birrane, Daniel Lightwood, Louise Howells, Geofrey Odede, Hanna Hailu, Shauna West, Rachel Garlish, Helen Neale, Carl Doyle, Adrian Moore, Gökhan S. Hotamisligil
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Role of Hypothalamic VGF in Energy Balance and Metabolic Adaption to Environmental Enrichment in Mice
Grant D. Foglesong, Wei Huang, Xianglan Liu, Andrew M. Slater, Jason Siu, Vedat Yildiz, Stephen R. J. Salton, Lei Cao
Endocrinology, 30 December 2015
PPARγ antagonist Gleevec improves insulin sensitivity and promotes the browning of white adipose tissue
Sunsil Choi, Eun-Sun Kim, Ji-Eun Jung, David P. Marciano, Ala Jo, Ja Young Koo, Soo Youn Choi, Yong Ryoul Yang, Hyun-Jun Jang, Eung-Kyun Kim, Jiyoung Park, Hyug Moo Kwon, In Hee Lee, Seung Bum Park, Kyung-Jae Myung, Pann-Ghill Suh, Patrick R. Griffin, Jang Hyun Choi
Diabetes, 6 January 2016
Collagen VI deficiency reduces muscle pathology, but does not improve muscle function, in the γ-sarcoglycan-null mouse
Jessica C. de Greef, Rebecca Hamlyn, Braden S. Jensen, Raul O'Campo Landa, Jennifer R. Levy, Kazuhiro Kobuke, Kevin P. Campbell
Human Molecular Genetics, 24 January 2016
Biodistribution, hypouricemic efficacy and therapeutic mechanism of morin phospholipid complex loaded self-nanoemulsifying drug delivery systems in an experimental hyperuricemic model in rats
Jinjie Zhang, Xiao Shuai, Jianbo Li, Nanxi Xiang, Tao Gong, Zhirong Zhang
Journal of Pharmacy and Pharmacology, 25 January 2016
USF1 deficiency activates brown adipose tissue and improves cardiometabolic health
Pirkka-Pekka Laurila, Jarkko Soronen, Sander Kooijman, Saara Forsström, Mariëtte R. Boon, Ida Surakka, Essi Kaiharju, Claudia P. Coomans, Sjoerd A. A. Van Den Berg, Anu Autio, Antti-Pekka Sarin, Johannes Kettunen, Emmi Tikkanen, Tuula Manninen, Jari Metso, Reija Silvennoinen, Krista Merikanto, Maija Ruuth, Julia Perttilä, Anne Mäkelä, Ayaka Isomi, Anita M. Tuomainen, Anna Tikka, Usama Abo Ramadan, Ilkka Seppälä, Terho Lehtimäki, Johan Eriksson, Aki Havulinna, Antti Jula, Pekka J. Karhunen, Veikko Salomaa, Markus Perola, Christian Ehnholm, Miriam Lee-Rueckert, Miranda Van Eck, Anne Roivainen, Marja-Riitta Taskinen, Leena Peltonen, Eero Mervaala, Anu Jalanko, Esa Hohtola, Vesa M. Olkkonen, Samuli Ripatti, Petri T. Kovanen, Patrick C. N. Rensen, Anu Suomalainen, Matti Jauhiainen
Science Translational Medicine, 27 January 2016
Adipocyte-specific Disruption of Fat-specific Protein 27 Causes Hepatosteatosis and Insulin Resistance in
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Naoki Tanaka, Shogo Takahashi, Tsutomu Matsubara, Changtao Jiang, Wataru Sakamoto, Tatyana Chanturiya, Ruifeng Teng, Oksana Gavrilova, and Frank J. Gonzalez
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Reduced Expression of MYC Increases Longevity and Enhances Healthspan
Jeffrey W. Hofmann, Xiaoai Zhao, Marco De Cecco, Abigail L. Peterson, Luca Pagliaroli, Jayameenakshi Manivannan, Gene B. Hubbard, Yuji Ikeno, Yongqing Zhang, Bin Feng, Xiaxi Li, Thomas Serre, Wenbo Qi, Holly Van Remmen, Richard A. Miller, Kevin G. Bath, Rafael de Cabo, Haiyan Xu, Nicola Neretti, John M. Sedivy
Cell, Volume 160, Issue 3, 29 January 2015, Pages 477-488
CTRP1 Protein Enhances Fatty Acid Oxidation via AMP-activated Protein Kinase (AMPK) Activation and Acetyl-CoA Carboxylase (ACC) Inhibition
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Resting Energy Expenditure and Energetic Cost of Feeding Are Augmented after Roux-en-Y Gastric Bypass in Obese Mice
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ChAT-ChR2-EYFP Mice Have Enhanced Motor Endurance But Show Deficits in Attention and Several Additional Cognitive Domains
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Beneficial effects of combinatorial micronutrition on body fat and atherosclerosis in mice
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High levels of whole-body energy expenditure are associated with a lower coupling of skeletal muscle mitochondria in C57Bl/6 mice
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Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue
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Diabetes January 2010 vol. 59 no. 1 17-25
Identification of a physiological role for leptin in the regulation of ambulatory activity and wheel running in mice.
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AJP - Endo November 2010 ajpendo.00546.2010
Sleeve gastrectomy and Roux-en-Y gastric bypass exhibit differential effects on food preferences, nutrient absorption and energy expenditure in obese rats
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Pharmacological Targeting of Glucagon and Glucagon-Like Peptide 1 Receptors Has Different Effects on Energy State and Glucose Homeostasis in Diet-Induced Obese Mice
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Ablations of Ghrelin and Ghrelin Receptor Exhibit Differential Metabolic Phenotypes and Thermogenic Capacity during Aging
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The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway
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JAX NOTES: NEWS FOR USERS OF JAX MICE & SERVICES
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A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain
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Early Mitochondrial Adaptations in Skeletal Muscle to Diet-Induced Obesity Are Strain Dependent and Determine Oxidative Stress and Energy Expenditure But Not Insulin Sensitivity
Sihem Boudina, Sandra Sena*, Crystal Sloan*, Ali Tebbi, Yong Hwan Han, Brian T. O'Neill, Robert C. Cooksey, Deborah Jones, William L. Holland, Donald A. McClain and E. Dale Abel
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Thyroid Hormone Receptor-α Gene Knockout Mice Are Protected from Diet-Induced Hepatic Insulin Resistance
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Genetic Models in Applied Physiology: Invited Review: Identifying new mouse models of cardiovascular disease: a review of high-throughput screens of mutagenized and inbred strains
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Mice With Hyperghrelinemia Are Hyperphagic and Glucose Intolerant and Have Reduced Leptin Sensitivity
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Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice
Zhanguo Gao, Jun Yin, Jin Zhang, Robert E. Ward, Roy J. Martin, Michael Lefevre, William T. Cefalu and Jianping Ye
Diabetes July 2009 vol. 58 no. 7 1509-1517
Pigment Epithelium–Derived Factor Regulates Lipid Metabolism via Adipose Triglyceride Lipase
Melissa L. Borg, Zane B. Andrews, Elia J. Duh, Rudolf Zechner, Peter J. Meikle and Matthew J. Watt
Diabetes May 2011 vol. 60 no. 5 1458-1466
Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice
Irene O.C.M. Vroegrijk, Janna A. van Diepen, Sjoerd van den Berg, Irene Westbroek, Hiskias Keizer, Luisa Gambelli, Raquel Hontecillas, Josep Bassaganya-Riera, Gerben C.M. Zondag, Johannes A. Romijn, Louis M. Havekes, Peter J. Voshol
Food and Chemical Toxicology
Volume 49, Issue 6, June 2011, Pages 1426-1430
Loss of G Protein ɣ7 Alters Behavior and Reduces Striatal αolf Level and cAMP Production*
William F. Schwindinger, Kelly S. Betz, Kathryn E. Giger, Angela Sabol, Sarah K. Bronson§, and Janet D. Robishaw
J. Biol. Chem., Vol. 278, Issue 8, 6575-6579, February 21, 2003
Adiponectin acts in the brain to decrease body weight
Yong Qi
1, Nobuhiko Takahashi
1, Stanley M Hileman
2, Hiralben R Patel
1, Anders H Berg
3, Utpal B Pajvani
3, Philipp E Scherer
3 & Rexford S Ahima
1
Nature Medicine 10, 524 - 529 (2004)
Bovine Growth Hormone Transgenic Mice Are Resistant to Diet-Induced Obesity but Develop Hyperphagia, Dyslipidemia, and Diabetes on a High-Fat Diet
Bob Olsson, Mohammad Bohlooly-Y, Sharyn M. Fitzgerald, Fredrik Frick, Anna Ljungberg, Bo Ahrén, Jan Törnell, Göran Bergström and Jan Oscarsson
Endocrinology Vol. 146, No. 2 920-930
Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet
Shireesh Srivastava, Yoshihiro Kashiwaya, M. Todd King, Ulrich Baxa, Joseph Tam, Gang Niu, Xiaoyuan Chen, Kieran Clarke and Richard L. Veech
The FASEB Journal vol. 26 no. 6 2351-2362 June 2012
TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity
Tatsuya Kusudo, Zhonghua Wang, Atsuko Mizuno, Makoto Suzuki, and Hitoshi Yamashita
Journal of Applied Physiology April 1, 2012 vol. 112 no. 7 1223-1232
Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice
Michael J. Jurczak, Ann-Hwee Lee, Francois R. Jornayvaz, Hui-Young Lee, Andreas L. Birkenfeld, Blas A. Guigni, Mario Kahn, Varman T. Samuel, Laurie H. Glimcher and Gerald I. Shulman
The Journal of Biological Chemistry, January 20, 2012, 287, 2558-2567.
Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity
Makoto Ishii *, Hong Fei * and Jeffrey M. Friedman
PNAS | September 2, 2003 | vol. 100 | no. 18 | 10540-10545
Loss of Agouti-Related Peptide Does Not Significantly Impact the Phenotype of Murine POMC Deficiency
Marcus P. Corander, Debra Rimmington, Benjamin G. Challis, Stephen O'Rahilly and Anthony P. Coll
Endocrinology May 1, 2011 vol. 152 no. 5 1819-1828
Role of Foxa-2 in adipocyte metabolism and differentiation
Christian Wolfrum,
1 David Q. Shih,
1 Satoru Kuwajima,
1 Andrew W. Norris,
2 C. Ronald Kahn,
2 and Markus Stoffel
1
J Clin Invest. 2003 August 1; 112(3): 345-356
Loss of histaminergic modulation of thermoregulation and energy homeostasis in obese mice
J. Sethi, M. Sanchez-Alavez, I.V. Tabarean
Neuroscience Volume 217, 16 August 2012, Pages 84-95
Dysregulation of insulin receptor substrate 2 in ß cells and brain causes obesity and diabetes
Xueying Lin, Akiko Taguchi, Sunmin Park, Jake A. Kushner, Fan Li, Yedan Li and Morris F. White
J. Clin. Invest. 114:908-916 (2004)
A Transgenic Mouse with a Deletion in the Collagenous Domain of Adiponectin Displays Elevated Circulating Adiponectin and Improved Insulin Sensitivity
Terry P. Combs, Utpal B. Pajvani, Anders H. Berg, Ying Lin, Linda A. Jelicks, Mathieu Laplante, Andrea R. Nawrocki, Michael W. Rajala, Albert. F. Parlow, Laurelle Cheeseboro, Yang-Yang Ding, Robert G. Russell, Dirk Lindemann, Adam Hartley, Glynn R. C. Baker, Silvana Obici, Yves Deshaies, Marian Ludgate, Luciano Rossetti and Philipp E. Scherer
Endocrinology Vol. 145, No. 1 367-383
Late-Onset Leanness in Mice with Targeted Ablation of Melanin Concentrating Hormone Neurons
Tamar Alon and Jeffrey Friedman
The Journal of Neuroscience, January 11, 2006 - 26(2):389-397
Mice lacking ghrelin receptors resist the development of diet-induced obesity
Jeffrey M. Zigman,
1 Yoshida Nakano,
1 Roberto Coppari,
1 Nina Balthasar,
1 Jacob N. Marcus,
1 Charolette E. Lee,
1 Juli E. Jones,
1 Amy E. Deysher,
1 Amanda R. Waxman,
1 Ryan D. White,
1 Todd D. Wiliams,
1 Jennifer L. Lachey,
1 Randy J. Seeley,
2 Bradford B. Lowell,
1, and Joel K. Elmquist
1,3
The Journal of Clinical Investigation Vol. 115, Number 12, Dec. 2005
Mice Deficient in the Respiratory Chain Gene Cox6a2 Are Protected against High-Fat Diet-Induced Obesity and Insulin Resistance
Roel Quintens, Sarvjeet Singh, Katleen Lemaire, Katrien De Bock, Mikaela Granvik, Anica Schraenen, Irene Olga Cornelia Maria Vroegrijk, Veronica Costa, Pieter Van Noten, Dennis Lambrechts, Stefan Lehnert, Leentje Van Lommel, Lieven Thorrez, Geoffroy De Faudeur, Johannes Anthonius Romijn, John Michael Shelton, Luca Scorrano, Henri Roger Lijnen, Peter Jacobus Voshol, Peter Carmeliet, Pradeep Puthenveetil Abraham Mammen, Frans Schuit
Research Article | published 27 Feb 2013 | PLOS ONE
10.1371/journal.pone.0056719
Antipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model
Robert K. Naviaux, Zarazuela Zolkipli, Lin Wang, Tomohiro Nakayama, Jane C. Naviaux, Thuy P. Le, Michael A. Schuchbauer, Mihael Rogac, Qingbo Tang, Laura L. Dugan, Susan B. Powell
Research Article | published 13 Mar 2013 | PLOS ONE
10.1371/journal.pone.0057380
Different Metabolic Responses to Central and Peripheral Injection of Enterostatin
Ling Lin
1, MieJung Park
1, Matt Hulver
1, and David A York
1*
Am J Physiol Regul Integr Comp Physiol (December 8, 2005). doi:10.1152/ajpregu.00045.2005
PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis
Teresa C. Leone
1,2, John J. Lehman
1,2, Brian N. Finck
1,2, Paul J. Schaeffer
1,2, Adam R. Wende
1,2, Sihem Boudina
3, Michael Courtois
1,2, David F. Wozniak
4, Nandakumar Sambandam
1,2, Carlos Bernal-Mizrachi
1,2, Zhouji Chen
2, John O. Holloszy
2, Denis M. Medeiros
5, Robert E. Schmidt
6, Jeffrey E. Saffitz
1,6, E. Dale Abel
3, Clay F. Semenkovich
1,2, Daniel P. Kelly
1,2,7,8*
PLoS Biology; Volume 3 | Issue 4 | APRIL 2005
Regulation of Skeletal Muscle Oxidative Capacity and Muscle Mass by SIRT3
Ligen Lin, Keyun Chen, Waed Abdel Khalek, Jack Lee Ward, Henry Yang, Béatrice Chabi, Chantal Wrutniak-Cabello, Qiang Tong
Research Article | published 15 Jan 2014 | PLOS ONE
10.1371/journal.pone.0085636
CD73 Is a Major Regulator of Adenosinergic Signalling in Mouse Brain
Natalia Kulesskaya, Vootele Võikar, Marjaana Peltola, Gennady G. Yegutkin, Marko Salmi, Sirpa Jalkanen, Heikki Rauvala
Research Article | published 12 Jun 2013 | PLOS ONE
10.1371/journal.pone.0066896
Methyl Donor Supplementation Blocks the Adverse Effects of Maternal High Fat Diet on Offspring Physiology
JesseLea Carlin, Robert George, Teresa M. Reyes
Research Article | published 02 May 2013 | PLOS ONE
10.1371/journal.pone.0063549
The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice
Xue Gao, Yong-Hyun Shin, Min Li, Fei Wang, Qiang Tong, Pumin Zhang
Research Article | published 16 Nov 2010 | PLOS ONE
10.1371/journal.pone.0014005
Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms
Efi Kokkotou,
1,3,4,* Justin Y. Jeon,
1,2,4,* Xiaomei Wang,
1 Francis E. Marino,
1,2 Michael Carlson,
1 Daniel J. Trombly,
1 and Eleftheria Maratos-Flier
1,2,4
Am J Physiol Regul Integr Comp Physiol 289: R117-R124, 2005
Running Performance at High Running Velocities Is Impaired but V'O2max and Peripheral Endothelial Function Are Preserved in IL-6-/- Mice
Marta Wojewoda, Katarzyna Kmiecik, Renée Ventura-Clapier, Dominique Fortin, Marta Onopiuk, Justyna Jakubczyk, Barbara Sitek, Andrzej Fedorowicz, Joanna Majerczak, Karol Kaminski, Stefan Chlopicki, Jerzy Andrzej Zoladz
Research Article | published 12 Feb 2014 | PLOS ONE
10.1371/journal.pone.0088333
APPROACHES TO HANDLING, BREEDING, STRAIN PRESERVATION, GENOTYPING, AND DRUG ADMINISTRATION FOR MOUSE MODELS OF CANCER
DAWNALYN BOGGESS, KATHLEEN A. SILVA, CARLISLE P. LANDEL, LARRY MOBRAATEN,
AND JOHN P. SUNDBERG
The Jackson Laboratory, Bar Harbor, Maine
Mouse Models of Human Cancer, edited by Eric C. Holland ISBN 0-471-44460-X
Dietary Quercetin Supplementation in Mice Increases Skeletal Muscle PGC1α Expression, Improves Mitochondrial Function and Attenuates Insulin Resistance in a Time-Specific Manner
Tara M. Henagan, Natalie R. Lenard, Thomas W. Gettys, Laura K. Stewart
Research Article | published 21 Feb 2014 | PLOS ONE
10.1371/journal.pone.0089365
Histaminergic regulation of seasonal metabolic rhythms in Siberian hamsters
Helen I'Anson, Preeti H. Jethwa, Amy Warner, Francis J.P. Ebling
Physiology & Behavior
Volume 103, Issues 3-4, 1 June 2011, Pages 268-278
Leptin action in the forebrain regulates the hindbrain response to satiety signals
Gregory J. Morton
1, James E. Blevins
2, Diana L. Williams
1, Kevin D. Niswender
1, Richard W. Gelling
1, Christopher J. Rhodes
3, Denis G. Baskin
2,4 and Michael W. Schwartz
1
J. Clin. Invest. 115:703-710 (2005)
Lack of Tryptophan Hydroxylase-1 in Mice Results in Gait Abnormalities
Georgette L. Suidan, Daniel Duerschmied, Gregory M. Dillon, Veronique Vanderhorst, Thomas G. Hampton, Siu Ling Wong, Jaymie R. Voorhees, Denisa D. Wagner
Research Article | published 14 Mar 2013 | PLOS ONE
10.1371/journal.pone.0059032
Depletion of the p43 mitochondrial T3 receptor in mice affects skeletal muscle development and activity
Laurence Pessemesse, Audrey Schlernitzauer, Chamroeun Sar, Jonathan Levin, Stéphanie Grandemange, Pascal Seyer, François B. Favier, Sandra Kaminski, Gérard Cabello, Chantal Wrutniak-Cabello and François Casas
The FASEB Journal
vol. 26 no. 2 748-756
AMP-activated Protein Kinase α2 Activity Is Not Essential for Contraction- and Hyperosmolarity-induced Glucose Transport in Skeletal Muscle*
Nobuharu Fujii, Michael F. Hirshman, Erin M. Kane, Richard C. Ho, Lauren E. Peter, Matthew M. Seifert, and Laurie J. Goodyear1
J. Biol. Chem., Vol. 280, Issue 47, 39033-39041, November 25, 2005
Sweet Taste Receptor Deficient Mice Have Decreased Adiposity and Increased Bone Mass
Becky R. Simon, Brian S. Learman, Sebastian D. Parlee, Erica L. Scheller, Hiroyuki Mori, William P. Cawthorn, Xiaomin Ning, Venkatesh Krishnan, Yanfei L. Ma, Björn Tyrberg, Ormond A. MacDougald
Research Article | published 22 Jan 2014 | PLOS ONE
10.1371/journal.pone.0086454
Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2
Nadeene Parker, Antonio J. Vidal-Puig, Vian Azzu, Martin D. Brand
Biochimica et Biophysica Acta (BBA) - Bioenergetics
Volume 1787, Issue 12, December 2009, Pages 1451-1457
Increased Lipolysis and Energy Expenditure in a Mouse Model with Severely Impaired Glucagon Secretion
Phing-How Lou, Natalia Gustavsson, Yue Wang, George K. Radda, Weiping Han
Research Article | published 27 Oct 2011 | PLOS ONE
10.1371/journal.pone.0026671
Ablation of Leptin Signaling to Somatotropes: Changes in Metabolic Factors that Cause Obesity
Noor Akhter, Angela K. Odle, Melody L. Allensworth-James, Anessa C. Haney, Mohsin M. Syed, Michael A. Cozart, Streamson Chua, Rhonda Kineman and Gwen V. Childs
Endocrinology October 1, 2012 vol. 153 no. 10 4705-4715
Responsiveness to Thyroid Hormone and to Ambient Temperature Underlies Differences Between Brown Adipose Tissue and Skeletal Muscle Thermogenesis in a Mouse Model of Diet-Induced Obesity
Cintia B. Ueta, Emerson L. Olivares and Antonio C. Bianco
Endocrinology September 1, 2011 vol. 152 no. 9 3571-3581
AMP Deaminase 3 Deficiency Enhanced 5'-AMP Induction of Hypometabolism
Isadora Susan Daniels, William G. O'Brien, Vinay Nath, Zhaoyang Zhao, Cheng Chi Lee
Research Article | published 16 Sep 2013 | PLOS ONE
10.1371/journal.pone.0075418
Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice
Ralf Schubert1,2,3, Laura Erker
1,2,3, Carrolee Barlow
4, Hiroyuki Yakushiji
1,2,3,¶, Denise Larson
4, Angelo Russo
5, James B. Mitchell
5 and Anthony Wynshaw-Boris
1,2,3,4,*
Human Molecular Genetics, 2004, Vol. 13, No. 16 1793-1802
Altered Lipid and Salt Taste Responsivity in Ghrelin and GOAT Null Mice
Huan Cai, Wei-na Cong, Caitlin M. Daimon, Rui Wang, Matthias H. Tschöp, Jean Sévigny, Bronwen Martin, Stuart Maudsley
Research Article | published 04 Oct 2013 | PLOS ONE
10.1371/journal.pone.0076553
A Novel Method for High Throughput Phenotyping of Sleep in Mice
Allan I Pack
1*, Raymond J. Galante
2, Greg Maislin
1, Jacqueline Cater
2, Dimitris Metaxas
3, Shan Lu
3, Lin Zhang
2, Randy Von Smith
4, Timothy Kay
2, Jie Lian
2, Karen Svenson
4, and Luanne L Peters
5
Physiol. Genomics (September 19, 2006). doi:10.1152/physiolgenomics.00139.2006
An Obligate Role of Oxytocin Neurons in Diet Induced Energy Expenditure
Zhaofei Wu, Yuanzhong Xu, Yaming Zhu, Amy K. Sutton, Rongjie Zhao, Bradford B. Lowell, David P. Olson, Qingchun Tong
Research Article | published 18 Sep 2012 | PLOS ONE
10.1371/journal.pone.0045167
Exercise Protects against Diet-Induced Insulin Resistance through Downregulation of Protein Kinase Cβ in Mice
Xiaoquan Rao, Jixin Zhong, Xiaohua Xu, Brianna Jordan, Santosh Maurya, Zachary Braunstein, Tse-Yao Wang, Wei Huang, Sudha Aggarwal, Muthu Periasamy, Sanjay Rajagopalan, Kamal Mehta, Qinghua Sun
Research Article | published 09 Dec 2013 | PLOS ONE
10.1371/journal.pone.0081364
Neuropeptide S Stimulates the Hypothalamo-Pituitary-Adrenal Axis and Inhibits Food Intake
Kirsty L. Smith, Michael Patterson, Waljit S. Dhillo, Sejal R. Patel, Nina M. Semjonous, James V. Gardiner, Mohammad A. Ghatei and Stephen R. Bloom
Endocrinology Vol. 147, No. 7 3510-3518
Targeted Inactivation of GPR26 Leads to Hyperphagia and Adiposity by Activating AMPK in the Hypothalamus
Daohong Chen, Xiaolei Liu, Weiping Zhang, Yuguang Shi
Research Article | published 16 Jul 2012 | PLOS ONE
10.1371/journal.pone.0040764
SIM1 Overexpression Partially Rescues Agouti Yellow and Diet-Induced Obesity by Normalizing Food Intake
Bassil M. Kublaoui, J. Lloyd Holder, Jr., Kristen P. Tolson, Terry Gemelli and Andrew R. Zinn
Endocrinology Vol. 147, No. 10 4542-4549
Mice Lacking the p43 Mitochondrial T3 Receptor Become Glucose Intolerant and Insulin Resistant during Aging
Christelle Bertrand, Emilie Blanchet, Laurence Pessemesse, Jean Sébastien Annicotte, Christine Feillet-Coudray, Béatrice Chabi, Jonathan Levin, Lluis Fajas, Gérard Cabello, Chantal Wrutniak-Cabello, François Casas
Research Article | published 30 Sep 2013 | PLOS ONE
10.1371/journal.pone.0075111
Endogenous Interleukin-10 Protects against Hepatic Steatosis but Does Not Improve Insulin Sensitivity during High-Fat Feeding in Mice
Marion A. M. den Boer, Peter J. Voshol, Janny P. Schröder-van der Elst, Elena Korsheninnikova, D. Margriet Ouwens, Folkert Kuipers, Louis M. Havekes and Johannes A. Romijn
Endocrinology Vol. 147, No. 10 4553-4558
Lecithin Cholesterol Acyltransferase Null Mice Are Protected from Diet-induced Obesity and Insulin Resistance in a Gender-specific Manner through Multiple Pathways
Lixin Li, Mohammad A. Hossain, Sabreena Sadat, Lauren Hager, Lu Liu, Laetitia Tam, Stephanie Schroer, Lu Huogen, I. George Fantus, Philip W. Connelly, Minna Woo and Dominic S. Ng
The Journal of Biological Chemistry, May 20, 2011, 286, 17809-17820.
Sim1 Haploinsufficiency Impairs Melanocortin-Mediated Anorexia and Activation of Paraventricular Nucleus Neurons
Bassil M. Kublaoui, J. Lloyd Holder, Jr., Terry Gemelli and Andrew R. Zinn
Molecular Endocrinology 20 (10): 2483-2492
Ablation of NG2 Proteoglycan Leads to Deficits in Brown Fat Function and to Adult Onset Obesity
Yunchao Chang, Zhi-Gang She, Kenji Sakimura, Amanda Roberts, Karolina Kucharova, David H. Rowitch, William B. Stallcup
PLoS ONE 7(1): e30637. doi:10.1371/journal.pone.0030637
High-fat diet induces emergence of brown-like adipocytes in white adipose tissue of spontaneously hypertensive rats
Silvie Hojna, Melissa D Jordan, Helen Kollias and Zdenka Pausova
Hypertension Research (2012) 35, 279-286; doi:10.1038/hr.2011.188
Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects
Brian J. Feldman*, Ryan S. Streeper, Robert V. Farese, Jr.
¶, and Keith R. Yamamoto,
||
PNAS | October 17, 2006 | vol. 103 | no. 42 | 15675-15680
Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease
Steven D. Kunkel, Christopher J. Elmore, Kale S. Bongers, Scott M. Ebert, Daniel K. Fox, Michael C. Dyle, Steven A. Bullard, Christopher M. Adams
Research Article | published 20 Jun 2012 | PLOS ONE
10.1371/journal.pone.0039332
Chronic PYY3-36 treatment promotes fat oxidation and ameliorates insulin resistance in C57BL6-mice
Anita M. van den Hoek
1, Annemieke C. Heijboer
2, Peter J. Voshol
2, Louis M. Havekes
3, Johannes A. Romijn
2, Eleonora P.M. Corssmit
2, and Hanno Pijl
2*
Am J Physiol Endocrinol Metab (August 29, 2006)
Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin
Ryan S. Streeper,
1,2 Suneil K. Koliwad,
1,2,3 Claudio J. Villanueva,
1,2 and Robert V. Farese, Jr.
1,2,3,4,5
Am J Physiol Endocrinol Metab 291: E388-E394, 2006.
PPAR{delta} regulates glucose metabolism and insulin sensitivity
Chih-Hao Lee*, Peter Olson, Andrea Hevener
¶, Isaac Mehl, Ling-Wa Chong, Jerrold M. Olefsky
¶, Frank J. Gonzalez
||, Jungyeob Ham**, Heonjoong Kang**, Jeffrey M. Peters, and Ronald M. Evans
PNAS | February 28, 2006 | vol. 103 | no. 9 | 3444-3449
Loss of IL-15 receptor ? alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles
Emidio E. Pistilli, Sasha Bogdanovich, Fleur Garton, Nan Yang, Jason P. Gulbin, Jennifer D. Conner, Barbara G. Anderson, LeBris S. Quinn, Kathryn North, Rexford S. Ahima, and Tejvir S. Khurana
J Clin Invest. Aug 1, 2011; 121(8): 3120-3132.
Comparison of sub-chronic metabolic effects of stable forms of naturally occurring GIP(1–30) and GIP(1–42) in high-fat fed mice
Victor A Gault, David W Porter, Nigel Irwin and Peter R Flatt
J Endocrinol March 1, 2011 208 265-271
Uncoupling Protein-2 Decreases the Lipogenic Actions of Ghrelin
Zane B. Andrews, Derek M. Erion, Rudolph Beiler, Charles S. Choi, Gerald I. Shulman and Tamas L. Horvath
Endocrinology May 1, 2010 vol. 151 no. 5 2078-2086
gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor
Ruth Janoschek
*, Leona Plum
*, Linda Koch
*, Heike Münzberg, Sabrina Diano
¶, Marya Shanabrough, Werner Müller
||, Tamas L. Horvath
¶,**, and Jens C. Brüning
*
PNAS | July 11, 2006 | vol. 103 | no. 28 | 10707-10712
Defective carbohydrate metabolism in mice homozygous for the tubby mutation
Yun Wang, Kevin Seburn, Lawrence Bechtel, Bruce Y. Lee, Jin P. Szatkiewicz, Patsy M. Nishina and Jürgen K. Naggert
Physiol. Genomics 27: 131-140, 2006. First published July 18, 2006
Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IKB Kinase β (IKKβ)/NF-KB Pathway
Qingyuan Meng and Dongsheng Cai
Journal of Biological Chemistry, 286, 32324-32332.
Inactivation of PKC{theta} Leads to Increased Susceptibility to Obesity and Dietary Insulin Resistance in Mice
Zhanguo Gao
1, Zhong Q Wang
2, Xiaoying Zhang
3, Andrew A Butler
4, Aamir Zuberi
5, Barbara Gawronska-Kozak
6, Michael Lefevre
7, David A. York
8, Eric Ravussin
9, Hans-Rudolf Berthoud
10, Owen P. McGuinness
11, William T. Cefalu
12, and Jianping Ye
13*
Am J Physiol Endocrinol Metab (August 8, 2006)
Maltase-Glucoamylase Modulates luconeogenesis and Sucrase-Isomaltase Dominates Starch Digestion Glucogenesis
Maricela Diaz-Sotomayor, Roberto Quezada-Calvillo, Stephen E. Avery, Shaji K. Chacko, yLi-ke Yan, yAmy Hui-Mei Lin, yZi-hua Ao, yBruce R. Hamaker, and Buford L. Nichols
JPGN Volume 57, Number 6, pages 704-712, December 2013
Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle*
Tonya L. Martin
1, Thierry Alquier
1, Kenji Asakura, Noboru Furukawa, Frederic Preitner, and Barbara B. Kahn
2
J. Biol. Chem., Vol. 281, Issue 28, 18933-18941, July 14, 2006
Telmisartan But Not Valsartan Increases Caloric Expenditure and Protects Against Weight Gain and Hepatic Steatosis
Ken Sugimoto; Nathan R. Qi; Ludmila Kazdová; Michal Pravenec; Toshio Ogihara; Theodore W. Kurtz
Hypertension. 2006;47:1003.
Muscle-specific overexpression of wild type and R225Q mutant AMP-activated protein kinase {gamma}3-subunit differentially regulates glycogen accumulation
Haiyan Yu, Michael F. Hirshman, Nobuharu Fujii, Jason M. Pomerleau, Lauren E. Peter, and Laurie J. Goodyear
Am J Physiol Endocrinol Metab 291: E557-E565, 2006
Contributions of dysregulated energy metabolism to type 2 diabetes development in NZO/H1Lt mice with polygenic obesity*1.
R. Koza, K. Flurkey, D. Graunke, C. Braun, H. Pan, P. Reifsnyder, L. Kozak, E. Leiter
Metabolism, Volume 53, Issue 6, Pages 799-808
Effect of hydroxycitrate on respiratory quotient, energy expenditure, and glucose tolerance in male rats after a period of restrictive feeding*1
Monika Leonhardt PhD, Börk Balkan PhD and Wolfgang Langhans DVM, PhD
Nutrition, Volume 20, Issue 10 , October 2004, Pages 911-915
Effect of adipocyte {beta}3-adrenergic receptor activation on the type 2 diabetic MKR mice
Hyunsook Kim,
1,3,* Patricia A. Pennisi,
1,* Oksana Gavrilova,
2 Stephanie Pack,
2 William Jou,
2 Jennifer Setser-Portas,
1 Joyce East-Palmer,
1 Yan Tang,
4 Vincent C. Manganiello,
4 and Derek LeRoith
1
Am J Physiol Endocrinol Metab 290: E1227-E1236, 2006
Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice
David J. Lloyd, Sandy Bohan and Nicholas Gekakis
Human Molecular Genetics 2006 15(11):1884-1893
NPY modulates PYY function in the regulation of energy balance and glucose homeostasis
L. Zhang, A. D. Nguyen, I.-C. J. Lee1, E. Yulyaningsih, S. J. Riepler, B. Stehrer, R. F. Enriquez, S. Lin1, Y.-C. Shi, P. A. Baldock, A. Sainsbury, H. Herzog
Diabetes, Obesity and Metabolism
Volume 14, Issue 8, pages 727-736, August 2012
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
Oksana Gavrilova
1, Bernice Marcus-Samuels
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2, Gerald I. Shulman
2, Arthur L. Castle
1, Charles Vinson
3, Michael Eckhaus
4 and Marc L. Reitman
1
J Clin Invest, February 2000, Volume 105, Number 3, 271-278
Improvements in Skeletal Muscle Strength and Cardiac Function Induced by Resveratrol Contribute to Enhanced Exercise Performance in Rats
Vernon W Dolinsky, Kelvin E Jones, Robinder S Sidhu, Mark Haykowsky, Michael P Czubryt, Tessa Gordon and Jason RB Dyck
The Journal of Physiology, April 2, 2012, doi:
10.1113/jphysiol.2012.230490
Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPAR{gamma} agonist’s effects on edema and weight gain
Konstantinos B. Sotiropoulos, Allen Clermont, Yutaka Yasuda, Christian Rask-Madsen, Motonobu Mastumoto, Junichi Takahashi, Kim Della Vecchia, Tatsuya Kondo, Lloyd P. Aiello and George L. King
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The FASEB Journal. 2006;20:1203-1205.
The enzyme CD38 (a NAD glycohydrose, EC 3.2.2.5) is necessary for the development of diet-induced obesity
Maria Thereza P. Barbosa,* Sandra M. Soares,* Colleen M. Novak, David Sinclair, James A. Levine, Pinar Aksoy, and Eduardo Nunes Chini*
, 1
The FASEB Journal. 2007;21:3629-3639
Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism
Mikael Bjursell
1,2, Andrea Ahnmark
1, Mohammad Bohlooly-Y
1,2, Lena William-Olsson
1, Magdalena Rhedin
1, Xiao-Rong Peng
1, Karolina Ploj
1, Anna-Karin Gerdin
1, Gunnel Arnerup
3, Anders Elmgren
1, Anna-Lena Berg
3, Jan Oscarsson
1,2,4, and Daniel Lindén
1,4
Diabetes 56:583-593, 2007
Effects of Manipulating Hypothalamic Triiodothyronine Concentrations on Seasonal Body Weight and Torpor Cycles in Siberian Hamsters
Michelle Murphy, Preeti H. Jethwa, Amy Warner, Perry Barrett, Kanishka N. Nilaweera, John M. Brameld and Francis J. P. Ebling
Endocrinology January 1, 2012 vol. 153 no. 1 101-112
Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy
Shengwen Zhang
1, Jamie M. Zeitzer
1,2, Takeshi Sakurai
3, Seiji Nishino
1 and Emmanuel Mignot
1,4
The Journal of Physiology
Volume 581 Issue 2 Page 649-663, June 2007
Circadian expression of genes regulating food intake.
Stütz AM, Staszkiewicz J, Ptitsyn A, Argyropoulos G.
Obesity (Silver Spring). 2007 Mar;15(3):607-15.
Hemodynamic effects of substance P and its receptor antagonist RP67580 in anesthetized rats with carbon tetrachloride-induced cirrhosis
Andres Cardenas
ab; Robert Lowe
c; Sangik Oh
a; Sheila Bodkin
c; Tom Kenney
c; Wayne W. Lamorte
d; Nezam H. Afdhal
a
Scandinavian Journal of Gastroenterology, Volume 43, Issue 3 2008 , pages 328 - 333
IL-15 Overexpression Promotes Endurance, Oxidative Energy Metabolism, and Muscle PPARδ, SIRT1, PGC-1α, and PGC-1β Expression in Male Mice
LeBris S. Quinn, Barbara G. Anderson, Jennifer D. Conner and Tami Wolden-Hanson
Endocrinology January 1, 2013 vol. 154 no. 1 232-245
Some metabolic effects on lactating rats of a low-energy diet restricted in good-quality protein
MarÃa del Rosario Ayala
a1, Radu Racotta
a1, Homero Hernández-Montes
a2 and LucÃa Quevedo
a1 c1
British Journal of Nutrition (2006), 96:667-673
Muscle-specific expression of PPAR{gamma} coactivator-1{alpha} improves exercise performance and increases peak oxygen uptake.
Jennifer A. Calvo,
1 Thomas G. Daniels,
1 Xiaomei Wang,
1 Angelika Paul,
2 Jiandie Lin,
3 Bruce M. Spiegelman,
3 Susan C. Stevenson,
1 and Shamina M. Rangwala
1
J Appl Physiol 104: 1304-1312, 2008
Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1{beta} administration
Keith W. Whitaker and Teresa M. Reyes
Neuropharmacology Volume 54, Issue 3, March 2008, Pages 509-520
PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism
Gema Medina-Gomez
1, Sarah L. Gray
1, Laxman Yetukuri
2, Kenju Shimomura
3, Sam Virtue
1, Mark Campbell
1, R. Keira Curtis
1, Mercedes Jimenez-Linan
1, Margaret Blount
1, Giles S. H. Yeo
1, Miguel Lopez
1, Tuulikki Seppänen-Laakso
2, Frances M. Ashcroft
3, Matej Oreši?
2, Antonio Vidal-Puig1*
PLoS Genetics April 2007 | Volume 3 | Issue 4 | e64
Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure
Tanya Hansotia,
1 Adriano Maida,
1 Grace Flock,
1 Yuichiro Yamada,
2 Katsushi Tsukiyama,
2 Yutaka Seino,
2 and Daniel. J. Drucker
1
J Clin Invest. 2007 January 2; 117(1): 143-152.
SKELETAL MUSCLE FIBER-TYPE SWITCHING, EXERCISE INTOLERANCE AND
MYOPATHY IN PGC-1a MUSCLE-SPECIFIC KNOCKOUT ANIMALS
Christoph Handschin
1,2, Sherry Chin
1, Ping Li
3, Fenfen Liu
4, Eleftheria Maratos-Flier
4,
Nathan K. LeBrasseur
5, Zhen Yan
3, and Bruce M. Spiegelman
1,6
J. Biol. Chem., Vol. 282, Issue 41, 30014-30021, October 12, 2007
Mice with selective elimination of striatal acetylcholine release are lean, show altered energy homeostasis and changed sleep/wake cycle
Monica S. Guzman, Xavier De Jaeger, Maria Drangova, Marco A. M. Prado, Robert Gros1, Vania F. Prado
Journal of Neurochemistry
Early View (Online Version of Record published before inclusion in an issue)
PAS kinase is required for normal cellular energy balance
Huai-Xiang Hao*, Caleb M. Cardon*, Wojtek Swiatek*, Robert C. Cooksey, Tammy L. Smith*, James Wilde*, Sihem Boudina, E. Dale Abel, Donald A. McClain, and Jared Rutter*
PNAS | September 25, 2007 | vol. 104 | no. 39 | 15466-15471
AgRP-deficiency could lead to increased life span
Stephen M. Redmann, Jr. and George Argyropoulos
Biochem Biophys Res Commun. 2006 December 29; 351(4): 860-864.
Nuclear Receptor Coactivator PNRC2 Regulates Energy Expenditure and Adiposity*
Dujin Zhou
1, Ruoqing Shen
1, Jing Jing Ye, Yuping Li, Walter Tsark, Donna Isbell
¶, Patrick Tso
||2, and Shiuan Chen
3
J. Biol. Chem., Vol. 283, Issue 1, 541-553, January 4, 2008
Serotonin 5-HT2C Receptor Agonist Promotes Hypophagia
via Downstream Activation of Melanocortin 4 Receptors
Daniel D. Lam,
1,2 Magdalena J. Przydzial,
1,2 Simon H. Ridley,
2 Giles S.H. Yeo,
2 Justin J. Rochford,
2
Stephen O’Rahilly,
2 and Lora K. Heisler
1,2*
Endocrinology. First published ahead of print November 26, 2007 as doi:10.1210/en.2007-1321
Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice
David Porter, Emilie Faivre, Peter R. Flatt, Christian Hölscher, Victor A. Gault
Peptides
Volume 35, Issue 1, May 2012, Pages 1-8
Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms
Yiying Zhang
1,2, Kaiying Guo
1, Robert E. LeBlanc
1, Daniella Loh
1, Gary J. Schwartz
3, and Yi-Hao Yu
4
Diabetes 56:1647-1654, 2007
Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation
David B. Lombard,
1,2, Frederick W. Alt,
1* Hwei-Ling Cheng,
1 Jakob Bunkenborg,
3M Ryan S. Streeper,
4, Raul Mostoslavsky,
1 Jennifer Kim,
1 George Yancopoulos,
5 David Valenzuela,
5 Andrew Murphy,
5 Yinhua Yang,
6,¶ Yaohui Chen,
6,|| Matthew D. Hirschey,
10 Roderick T. Bronson,
7 Marcia Haigis,
8,# Leonard P. Guarente,
8 Robert V. Farese Jr.,
4,9 Sherman Weissman,
6 Eric Verdin,
10* and Bjoern Schwer
1,10
Molecular and Cellular Biology, December 2007, p. 8807-8814, Vol. 27, No. 24
Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice
Masa Katic
1, Adam R. Kennedy
2, Igor Leykin
1, Andrew Norris
3, Aileen McGettrick
1, Stephane Gesta
1, Steven J. Russell
1, Matthias Bluher
4, Eleftheria Maratos-Flier
2 and C. Ronald Kahn
1
Aging Cell Volume 6 Issue 6 Page 827-839, December 2007
The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides
Corina J. A. Moen1,* Aart P. Tholens*, Peter J. Voshol, Willeke de Haan, Louis M. Havekes,** Peter Gargalovic, Aldons J. Lusis, Ko Willems van Dk*,** Rune R. Frants*, Marten H. Hofker***, and Patrick C. N. Rensen,**
Journal of Lipid Research, Vol. 48, 2182-2192, October 2007
PGC-1{beta} controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis
Junichiro Sonoda, Isaac R. Mehl, Ling-Wa Chong, Russell R. Nofsinger, and Ronald M. Evans*
PNAS | March 20, 2007 | vol. 104 | no. 12 | 5223-5228
Cannabinoid-induced hyperphagia: Correlation with inhibition of proopiomelanocortin neurons?
Jennie Ho, Jeremy M. Cox and Edward J. Wagner
Physiology & Behavior Volume 92, Issue 3, 22 October 2007, Pages 507-519
A high-fat, ketogenic diet induces a unique metabolic state in mice
Adam R. Kennedy,
1 Pavlos Pissios,
1 Hasan Otu,
2 Bingzhong Xue,
1 Kenji Asakura,
1 Noburu Furukawa,
1 Frank E. Marino,
1 Fen-Fen Liu,
1 Barbara B. Kahn,
1 Towia A. Libermann,
2 and Eleftheria Maratos-Flier
1
Am J Physiol Endocrinol Metab 292: E1724-E1739, 2007
Inactivation of the Mitochondrial Carrier SLC25A25 (ATP-Mg2+/Pi Transporter) Reduces Physical Endurance and Metabolic Efficiency in Mice*
Rea P. Anunciado-Koza, Jingying Zhang, Jozef Ukropec, Sudip Bajpeyi, Robert A. Koza, Richard C. Rogers, William T. Cefalu, Randall L. Mynatt and Leslie P. Kozak
The Journal of Biological Chemistry, 286, 11659-11671.
Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner
Young Joo Park, Seong Chul Kim, Jeehee Kim, Sayeepriyadarshini Anakk, Jae Man Lee, Hsiu-Ting Tseng, Vijay Yechoor, Junchol Park, June-Seek Choi, Hak Chul Jang, Ki-Up Lee, Colleen M. Novak, David D. Moore and Yoon Kwang Lee
Lipid Research, 52, 2234-2244.
Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity
Lake Q. Jiang, Pablo M. Garcia-Roves, Thais de Castro Barbosa, and Juleen R. Zierath
AJP - Endo January 1, 2010 vol. 298 no. 1 E8-E16
Adiponectin gene therapy ameliorates high-fat, high-sucrose diet-induced metabolic perturbations in mice
A D Kandasamy, M M Sung, J J Boisvenue, A J Barr and J R B Dyck
Nutrition and Diabetes (2012) 2, e45; doi:10.1038/nutd.2012.18
Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice
Katrine Almind*, Monia Manieri, William I. Sivitz, Saverio Cinti, and C. Ronald Kahn*
,¶
PNAS | February 13, 2007 | vol. 104 | no. 7 | 2366-2371
Peptide YY Regulates Bone Turnover in Rodents.
Katherine E. Wortley, Karen Garcia, Haruka Okamoto, Karen Thabet, Keith D. Anderson, Victor Shen, Jim P. Herman, David Valenzuela, George D. Yancopoulos, Matthias H. Tschöp, Andrew Murphy and Mark W. Sleeman
Gastroenterology Volume 133, Issue 5, November 2007, Pages 1534-1543
Gastric Bypass Surgery Causes Body Weight Loss Without Reducing Food Intake in Rats
Marianne W. Furnes
1, Karin Tommeras
1, Carl-Jorgen Arum
1, 2, Chun-Mei Zhao
1 and Duan Chen
1
Obesity Surgery Volume 18, Number 4 / April, 2008 Pages 415-422
Effects of acute and chronic relaxin-3 on food intake and energy expenditure in rats
B.M. McGowan, S.A. Stanley, K.L. Smith, J.S. Minnion, J. Donovan, E.L. Thompson, M. Patterson, M.M. Connolly, C.R. Abbott, C.J. Small, J.V. Gardiner, M.A. Ghatei and S.R. Bloom
Regulatory Peptides Volume 136, Issues 1-3, 11 September 2006, Pages 72-77
Phenotypic screening of hepatocyte nuclear factor (HNF) 4-{gamma} receptor knockout mice
Anna Karin Gerdin, Vikas V. Surve, Marie Jönsson, Mikael Bjursell, Maria Björkman, Anne Edenro, Meint Schuelke, Alaa Saad, Sivert Bjurström, Elisabeth Jensen Lundgren, Michael Snaith, Ronny Fransson-Steen, Jan Törnell, Anna-Lena Berg and Mohammad Bohlooly-Y
Biochemical and Biophysical Research Communications Volume 349, Issue 2, 20 October 2006, Pages 825-832
PGC-1α Improves Glucose Homeostasis in Skeletal Muscle in an Activity-Dependent Manner
Serge Summermatter, Guanghou Shui, Daniela Maag, Gesa Santos, Markus R. Wenk2 and Christoph Handschin
Diabetes January 2013 vol. 62 no. 1 85-95
Collective and Individual Functions of Leptin Receptor Modulated Neurons Controlling Metabolism and Ingestion
Esther van de Wall, Rebecca Leshan, Allison W. Xu, Nina Balthasar, Roberto Coppari, Shun Mei Liu, Young Hwan Jo, Robert G. MacKenzie, David B. Allison, Nae J. Dun, Joel Elmquist, Bradford B. Lowell, Gregory S. Barsh, Carl de Luca, Martin G. Myers, Jr., Gary J. Schwartz and Streamson C. Chua, Jr.
Endocrinology Vol. 149, No. 4 1773-1785
Adipose tissue integrity as a prerequisite for systemic energy balance : a critical role for PPAR{gamma}
Silvia I. Anghel
1, Elodie Bedu
1, Celine Delucinge Vivier
2, Patrick Descombes
2, Béatrice Desvergne
1 and Walter Wahli
1*
J. Biol. Chem., Vol. 282, Issue 41, 29946-29957, October 12, 2007
Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice
W D Porter, P R Flatt, C Hölscher and V A Gault
International Journal of Obesity advance online publication 5 June 2012; doi: 10.1038/ijo.2012.91
Role of hypothalamic interleukin-1{beta} (IL-1{beta}) in regulation of energy homeostasis by melanocortins
Brent E. Wisse, Kayoko Ogimoto and Michael W. Schwartz
Peptides Volume 27, Issue 2, February 2006, Pages 265-273
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
Jennifer W. Hill,
1 Kevin W. Williams,
1 Chianping Ye,
2 Ji Luo,
3 Nina Balthasar,
4 Roberto Coppari,
1 Michael A. Cowley,
5 Lewis C. Cantley,
3 Bradford B. Lowell,
2 and Joel K. Elmquist
1
J Clin Invest. 2008 May 1; 118(5): 1796-1805.
Hematopoietic Cell–Restricted Deletion of CD36 Reduces High-Fat Diet–Induced Macrophage Infiltration and Improves Insulin Signaling in Adipose Tissue
Hayley T. Nicholls, Greg Kowalski, David J. Kennedy, Steve Risis, Lee A. Zaffino, Nadine Watson, Peter Kanellakis, Matthew J. Watt, Alex Bobik, Arend Bonen, Maria Febbraio, Graeme I. Lancaster and Mark A. Febbraio
Diabetes April 2011 vol. 60 no. 4 1100-1110
Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses
Richard Torres, Susan D. Croll, Jeffrey Vercollone, Joel Reinhardt, Jennifer Griffiths, Stephanie Zabski, Keith D. Anderson, Niels C. Adams, Lori Gowen, Mark W. Sleeman, David M. Valenzuela, Stanley J. Wiegand, George D. Yancopoulos and Andrew J. Murphy
Pain Volume 130, Issue 3, August 2007, Pages 267-278
Serotonin 2C Receptor Agonists Improve Type 2 Diabetes via Melanocortin-4 Receptor Signaling Pathways
Ligang Zhou
1, 2, 8, Gregory M. Sutton
3, 8, Justin J. Rochford
1, Robert K. Semple
1, Daniel D. Lam
1, Laura J. Oksanen
4, Zoe D. Thornton-Jones
5, Peter G. Clifton
5, Chen-Yu Yueh
6, Mark L. Evans
6, Rory J. McCrimmon
2, Joel K. Elmquist
7, Andrew A. Butler
3, and Lora K. Heisler
1
Cell metabolism, Volume 6, Issue 5, 7 November 2007, Pages 398-405
Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice
Mikael Bjursell,
1 Anna-Karin Gerdin,
1 Christopher J. Lelliott,
1 Emil Egecioglu,
2 Anders Elmgren,
1 Jan Törnell,
1,2 Jan Oscarsson,
1,2 and Mohammad Bohlooly-Y
1,2
Am J Physiol Endocrinol Metab 294: E251-E260, 2008
Double leptin (Lepob) and melanocortin-4 receptor (Mc4r) gene mutations have an additive effect on fat mass, and are associated with reduced effects of leptin on weight loss and food intake
James L. Trevaskis and Andrew A. Butler*
Endocrinology Vol. 146, No. 10 4257-4265
The effects of pancreatic polypeptide on locomotor activity and food intake in mice.
Y-L Liu
1, KG Murphy, MA Ghatei and SR Bloom
International Journal of Obesity (2008) 32, 1712-1715
Anaplerotic Triheptanoin Diet Enhances Mitochondrial Substrate Use to Remodel the Metabolome and Improve Lifespan, Motor Function, and Sociability in MeCP2-Null Mice
Min Jung Park, Susan Aja, Qun Li, Alicia L. Degano, Judith Penati, Justin Zhuo, Charles R. Roe, Gabriele V. Ronnett
PLOS ONE, October 09, 2014 DOI: 10.1371/journal.pone.0109527
Feeding and Metabolism in Mice Lacking Pituitary Adenylate Cyclase-Activating Polypeptide
Bruce A. Adams
1, Sarah L. Gray
1, Emma R. Isaac, Antonio C. Bianco, Antonio J. Vidal-Puig and Nancy M. Sherwood
Endocrinology Vol. 149, No. 4 1571-1580
Dihydrotestosterone Treatment Results in Obesity and Altered Lipid Metabolism in Orchidectomized Mice
ofia Movérare-Skrtic, Katrien Venken, Niklas Andersson, Marie K. Lindberg, Johan Svensson, Charlotte Swanson, Dirk Vanderschueren, Jan Oscarsson, Jan-Åke Gustafsson, Claes Ohlsson
Obesity Volume 14, Issue 4, pages 662-672, April 2006
Disruption of Thyroid Hormone Activation in Type 2 Deiodinase Knockout Mice Causes Obesity With Glucose Intolerance and Liver Steatosis Only at Thermoneutrality
Melany Castillo, Jessica A. Hall, Mayrin Correa-Medina, Cintia Ueta, Hye Won Kang, David E. Cohen and Antonio C. Bianco
Diabetes April 2011 vol. 60 no. 4 1082-1089
Disruption of the Circadian Output Molecule Prokineticin 2 Results in Anxiolytic and Antidepressant-like Effects in Mice
Jia-Da Li
1,2, Wang-Ping Hu
1,2 and Qun-Yong Zhou
1
Neuropsychopharmacology (2009) 34, 367-373
Signal Transducer and Activator of Transcription-3 Is Required in Hypothalamic Agouti-Related Protein/Neuropeptide Y Neurons for Normal Energy Homeostasis
Lijie Gong
1, Fayi Yao
1, Kristin Hockman, Henry H. Heng, Gregory J. Morton, Kiyoshi Takeda, Shizuo Akira, Malcolm J. Low, Marcelo Rubinstein and Robert G. MacKenzie
Endocrinology Vol. 149, No. 7 3346-3354
Selective Inactivation of Socs3 in SF1 Neurons Improves Glucose Homeostasis without Affecting Body Weight
Ren Zhang, Harveen Dhillon, Huali Yin, Akihiko Yoshimura, Bradford B. Lowell, Eleftheria Maratos-Flier and Jeffrey S. Flier
Endocrinology Vol. 149, No. 11 5654-5661
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
Qingchun Tong
1, Chian-Ping Ye
1, Juli E Jones
1, Joel K Elmquist
2 & Bradford B Lowell
1
Nature Neuroscience 11, 998 - 1000 (2008)
Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice
Kenneth A. Longo
a, Soratree Charoenthongtrakul
a, Derek J. Giuliana
a, Elizabeth K. Govek
a, Thomas McDonagh
a, Yong Qi
a, Peter S. DiStefano
a and Brad J. Geddes
a
Regulatory Peptides Volume 150, Issues 1-3, 9 October 2008, Pages 55-61
S6K1 in the Central Nervous System Regulates Energy Expenditure via MC4R/CRH Pathways in Response to Deprivation of an Essential Amino Acid
Tingting Xia, Ying Cheng, Qian Zhang, Fei Xiao, Bin Liu, Shanghai Chen and Feifan Guo
Diabetes October 2012 vol. 61 no. 10 2461-2471
Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor
Andrea Frassetto
a, Jiaping Zhang
a, Julie Z. Lao
a, Amanda White
b, Joseph M. Metzger
b, Tung M. Fong
a and Richard Z. Chen
a
Brain Research Volume 1236, 21 October 2008, Pages 140-144
Loss of prokineticin receptor 2 signaling predisposes mice to torpor
Preeti H. Jethwa,
1 Helen I'Anson,
2 Amy Warner,
1 Hayden M. Prosser,
3 Michael H. Hastings,
4 Elizabeth S. Maywood,
4 and Francis J. P. Ebling
1
Am J Physiol Regul Integr Comp Physiol 294: R1968-R1979, 2008
Substance P as a novel anti-obesity target
Iordanes Karagiannides,
1 Daniel Torres,
1 Yu-Hua Tseng,
2 Collin Bowe,
1 Eugenia Carvalho,
1 Daniel Espinoza,
1 Charalabos Pothoulakis,
1,3* and Efi Kokkotou
1,3*
Gastroenterology. 2008 March; 134(3): 747-755.
Influence of the Hepatic Eukaryotic Initiation Factor 2α (eIF2α) Endoplasmic Reticulum (ER) Stress Response Pathway on Insulin-mediated ER Stress and Hepatic and Peripheral Glucose Metabolism
Andreas L. Birkenfeld, Hui-Young Lee, Sachin Majumdar, Michael J. Jurczak, Joao Paulo Camporez, Francois R. Jornayvaz, David W. Frederick, Blas Guigni, Mario Kahn, Dongyang Zhang, Dirk Weismann, Ayman M. Arafat, Andreas F. Pfeiffer, Stefanie Lieske, Seiichi Oyadomari, David Ron, Varman T. Samuel and Gerald I. Shulman
Journal of Biological Chemistry, 286, 36163-36170.
Extending food deprivation reverses the short-term lipolytic response to fasting: role of the triacylglycerol/fatty acid cycle
Jean-Michel Weber and Shannon P. Reidy
J Exp Biol 215, 1484-1490
Inhibition of ADRP prevents diet-induced insulin resistance
Gladys M. Varela,
1,2 Daniel A. Antwi,
1,2 Ravindra Dhir,
1,2 Xiaoyan Yin,
1,2 Neel S. Singhal,
1,2 Mark J. Graham,
3 Roseanne M. Crooke,
3 and Rexford S. Ahima
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Am J Physiol Gastrointest Liver Physiol 295: G621-G628, 2008
Long-term effects of dietary glycemic index on adiposity, energy metabolism, and physical activity in mice
Kelly B. Scribner, Dorota B. Pawlak, Cristin M. Aubin, Joseph A. Majzoub, and David S. Ludwig
Am J Physiol Endocrinol Metab 295: E1126-E1131, 2008
Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle
Elaine Vieira,
1 Elisabeth C. Nilsson,
2 Annika Nerstedt,
2 Mattias Ormestad,
2 Yun Chau Long,
1 Pablo M. Garcia-Roves,
1 Juleen R. Zierath,
1 and Margit Mahlapuu
2,3
Am J Physiol Endocrinol Metab 295: E1032-E1037, 2008
Feeding Behavior in Rats Subjected to Gastrectomy or Gastric Bypass Surgery
M.W. Furnes
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a, K. Tømmerås
a, T. Skoglund
a, S.L. Dickson
c, B. Kulseng
b, C.-M. Zhao
a, D. Chen
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Eur Surg Res 2008;40:279-288
Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice
Mathieu Ferron, Marc D. McKee, Robert L. Levine, Patricia Ducy, Gérard Karsenty
Bone, Volume 50, Issue 2, February 2012, Pages 568-575
Reciprocal Metabolic Perturbations in the Adipose Tissue and Liver of GPIHBP1-Deficient Mice
Michael M. Weinstein, Christopher N. Goulbourne, Brandon S.J. Davies, Yiping Tu, Richard H. Barnes II, Steven M. Watkins, Ryan Davis, Karen Reue, Peter Tontonoz, Anne P. Beigneux, Loren G. Fong, Stephen G. Young
Arteriosclerosis, Thrombosis, and Vascular Biology.
2012; 32: 230-235
Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice
Alexander V. Mayorov
a,b, Neri Amara
c, Jason Y. Chang
a,b, Jason A. Moss
a,b Mark S. Hixon
a,b, Diana I. Ruiz
a,b, Michael M. Meijler
c,1, Eric P. Zorrilla
d,e,1, and Kim D. Janda
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PNAS November 11, 2008 vol. 105 no. 45 17487-17492
Endogenous Peroxisome Proliferator-Activated Receptor-{gamma} Augments Fatty Acid Uptake in Oxidative Muscle
Andrew W. Norris, Michael F. Hirshman, Jianrong Yao, Niels Jessen, Nicolas Musi, Lihong Chen, William I. Sivitz, Laurie J. Goodyear and C. Ronald Kahn
Endocrinology Vol. 149, No. 11 5374-5383
Overexpression of KLF15 Transcription Factor in Adipocytes of Mice Results in Down-regulation of SCD1 Protein Expression in Adipocytes and Consequent Enhancement of Glucose-induced Insulin Secretion*
Tomoki Nagare, Hiroshi Sakaue, Michihiro Matsumoto, Yongheng Cao, Kenjiro Inagaki, Mashito Sakai, Yasuhiro Takashima, Kyoko Nakamura, Toshiyuki Mori, Yuko Okada, Yasushi Matsuki, Eijiro Watanabe, Kazutaka Ikeda, Ryo Taguchi, Naomi Kamimura, Shigeo Ohta, Ryuji Hiramatsu and Masato Kasuga
ournal of Biological Chemistry, 286, 37458-37469.
Deletion of Cavin/PTRF Causes Global Loss of Caveolae, Dyslipidemia, and Glucose Intolerance
Libin Liu
1, Dennis Brown
2, Mary McKee
2, Nathan K. LeBrasseur
3, 5, Dan Yang
1, Kenneth H. Albrecht
4, Katya Ravid
1 and Paul F. Pilch
1
Cell Metabolism, Volume 8, Issue 4, 8 October 2008, Pages 310-317
SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis
Russell R. Nofsinger
a, Pingping Li
b, Suk-Hyun Hong
a, Johan W. Jonker
a, Grant D. Barish
a, Hao Ying
c, Sheue-yann Cheng
c, Mathias LeBlanc
a, Wei Xu
d, Liming Pei
a, Yeon-Joo Kang
e, Michael Nelson
a, Michael Downes
a, Ruth T. Yu
a, Jerrold M. Olefsky
b, Chih-Hao Lee
f, and Ronald M. Evans
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PNAS December 16, 2008 vol. 105 no. 50 20021-20026
Paradoxical effects of increased expression of PGC-1{alpha} on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
Cheol Soo Choi
a,b,1 Douglas E. Befroy
a,1, Roberto Codella
a,1, Sheene Kim
a, Richard M. Reznick
a, Yu-Jin Hwang
a, Zhen-Xiang Liu
a, Hui-Young Lee
a, Alberto Distefano
a, Varman T. Samuel
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