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Excess coenzyme A reduces skeletal muscle performance and strength in mice overexpressing human PANK2
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Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition
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The American Journal of Pathology, Volume 187, Issue 4, Pages 700-712
17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization
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Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice
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American Journal of Physiology - Regulatory, Integrative and Comparative Physiology Published 2 November 2016 Vol. no. , DOI: 10.1152/ajpregu.00346.2016
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A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice
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Deletion of Lkb1 in adult mice results in body weight reduction and lethality
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Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus, and skeletal muscle of mice
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Deletion of the Vesicular Acetylcholine Transporter from Pedunculopontine/laterodorsal tegmental neurons modifies gait
Helena Janickova, Kaie Rosborough, Mohammed Al-Onaizi, Ornela Kljakic,
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Resveratrol supplementation to high fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring
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J Physiol. 28 November 2016. doi:10.1113/JP273478
FIAT deletion increases bone mass but does not prevent high-fat-diet-induced metabolic complications
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17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization
Michael B. Stout, Frederik J. Steyn, Michael J. Jurczak, Joao-Paulo G. Camporez, Yi Zhu, John R. Hawse, Diana Jurk, Allyson K. Palmer, Ming Xu, Tamar Pirtskhalava, Glenda L. Evans, Roberta de Souza Santos, Aaron P. Frank, Thomas A. White, David G. Monroe, Ravinder J. Singh, Grace Casaclang-Verzosa, Jordan D. Miller, Deborah J. Clegg, Nathan K. LeBrasseur, Thomas von Zglinicki, Gerald I. Shulman, Tamara Tchkonia, and James L. Kirkland
J Gerontol A Biol Sci Med Sci. 2017 Jan; 72(1): 3–15.
Transcription Factor EB Controls Metabolic Flexibility during Exercise
Gelsomina Mansueto, Andrea Armani, Carlo Viscomi, Luca D’Orsi, Rossella De Cegli, Elena V. Polishchuk, Costanza Lamperti, Ivano Di Meo, Vanina Romanello, Silvia Marchet, Pradip K. Saha, Haihong Zong, Bert Blaauw, Francesca Solagna, Caterina Tezze, Paolo Grumati, Paolo Bonaldo, Jeffrey E. Pessin, Massimo Zeviani, Marco Sandri, and Andrea Ballabio
Cell Metabolism 25, 182–196 January 10, 2017
Adipose-specific ablation of Nrf2 transiently delayed high-fat diet-induced obesity by altering glucose, lipid and energy metabolism of male mice
Le Zhang, Kalavathi Dasuri, Sun-Ok Fernandez-Kim, Annadora J Bruce-Keller, and Jeffrey N Keller
Am J Transl Res. 2016; 8(12): 5309–5319
Hypothalamus specific re-introduction of Snord116 into otherwise Snord116 deficient mice increased energy expenditure
Y Qi, L Purtell, M Fu, L Zhang, S Zolotukhin, L Campbell, H Herzog
J. of Neuroendocrinology, 17 January 2017, DOI: 10.1111/jne.12457
TLR4 Knockout Attenuated High Fat Diet-Induced Cardiac Dysfunction via NF-?B/JNK-Dependent Activation of Autophagy
Nan Hu, Yingmei Zhang
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Available online 17 January 2017
Oxygen regulation of breathing through an olfactory receptor activated by lactate
Andy J. Chang, Fabian E. Ortega, Johannes Riegler, Daniel V. Madison, Mark A. Krasnow
Nature, 11 November 2015
Effects of High Intensity Interval Training on Pregnant Rats, and the Placenta, Heart and Liver of Their Fetuses
Nils Thomas Songstad, Knut-Helge Frostmo Kaspersen, Anne Dragøy Hafstad, Purusotam Basnet, Kirsti Ytrehus, Ganesh Acharya
PLOS One, 13 November 2015
Topiramate Treatment Improves Hypothalamic Insulin and Leptin Signaling and Action and Reduces Obesity in Mice
Andrea M. Caricilli, Erica Penteado, Lélia L. de Abreu, Paula G. F. Quaresma, Andressa C. Santos, Dioze Guadagnini, Daniella Razolli, Francine C. Mittestainer, Jose B. Carvalheira, Licio A. Velloso, Mario J. A. Saad and Patricia O. Prada
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Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function
Katsuhiko Funai, Irfan J. Lodhi, Larry D. Spears, Li Yin, Haowei Song, Samuel Klein, Clay F. Semenkovich
Diabetes, 28 October 2015
Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline
Derek M. Huffman, Gabriela Farias Quipildor, Kai Mao, Xueying Zhang, Junxiang Wan, Pasha Apontes, Pinchas Cohen, Nir Barzilai
Aging Cell, 4 November 2015
Signaling through Tyr985 of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance
Jia You, Yue Yu, Lei Jiang, Wenxia Li, Xinxin Yu, Lety Gonzalez, Guoqing Yang,,Zunji Ke, Wenjun Li, Cai Li, and Yong Liu
Mol. Cell. Biol. 30 (7): 1650-1659
Angiotensin II-induced reduction in exercise capacity is associated with increased oxidative stress in skeletal muscle
Naoki Inoue, Shintaro Kinugawa, Tadashi Suga, Takashi Yokota, Kagami Hirabayashi, Satoshi Kuroda, Koichi Okita, and Hiroyuki Tsutsui
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Advantages of dynamic “closed loop†stable isotope flux phenotyping over static “open loop†clamps in detecting silent genetic and dietary phenotypes
Bhavapriya Vaitheesvaran, Fu-Yu Chueh, Jun Xu, Chuck Trujillo, M. F. Saad, W. N. P. Lee, Owen P. McGuinness and Irwin J. Kurland
Metabolomics Volume 6, Number 2, 180-190
Low-dose arsenic-mediated metabolic shift is associated with activation of Polo-like kinase 1 (Plk1)
Zhiguo Li, Ying Lu, Nihal Ahmad, Klaus Strebhardt, Xiaoqi Liu
Cell Cycle, 20 August 2015
Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats.
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Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3
Huating Li, Zhanguo Gao, Jin Zhang, Xin Ye, Aimin Xu, Jianping Ye and Weiping Jia
Diabetes April 2012 vol. 61 no. 4 797-806
Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance
R. Palanivel, M. D. Fullerton, S. Galic, J. Honeyman, K. A. Hewitt, S. B. Jorgensen, G. R. Steinberg
Diabetologia
November 2012, Volume 55, Issue 11, pp 3083-3093
Angiotensin II Receptor Blocker Improves the Lowered Exercise Capacity and Impaired Mitochondrial Function of the Skeletal Muscle in Type 2 Diabetic Mice
Shingo Takada, Shintaro Kinugawa, Kagami Hirabayashi, Tadashi Suga, Takashi Yokota, Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Taisuke Ono, Mochamad Ali Sobirin, Yoshihiro Masaki, Tomoyasu Kadoguchi, Koichi Okita, and Hiroyuki Tsutsui
ournal of Applied Physiology January 17, 2013 jap.00053.2012
Identification of Body Fat Mass as a Major Determinant of Metabolic Rate in Mice
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Diabetes July 2010 vol. 59 no. 7 1657-1666
Anti-Obesity Effects of Androgens,
Dehydroepiandrosterone (DHEA) and Testosterone
Kazuo Kajita, Ichiro Mori, Masahiro, Takahide Ikeda, Hiroyuki Morita and Tatsuo Ishizuka
Treatment of Type 2 Diabetes, Chapter 12, p295-312, April 2015
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Exendin-4 Improves Thermogenic Capacity by Regulating Fat Metabolism on Brown Adipose Tissue in Mice with Diet-Induced Obesity
Qiong Wei, Ling Li, Ji-an Chen, Shao-hua Wang and Zi-lin Sun
Ann Clin Lab Sci March-April 2015 vol. 45 no. 2 158-165
The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity
Ahrathy Selathurai, Greg M. Kowalski, Micah L. Burch, Patricio Sepulveda, Steve Risis, Robert S. Lee-Young, Severine Lamon, Peter J. Meikle, Amanda J. Genders, Sean L. McGee, Matthew J. Watt, Aaron P. Russell, Matthew Frank, Suzanne Jackowski, Mark A. Febbraio, Clinton R. Bruce
Cell Metabolism, Volume 21, Issue 5, p718-730, 5 May 2015
Regenerative Therapy Prevents Heart Failure Progression in Dyssynchronous Nonischemic Narrow QRS Cardiomyopathy
Satsuki Yamada, MD, PhD; D. Kent Arrell, PhD; Almudena Martinez-Fernandez, PhD; Atta Behfar, MD, PhD; Garvan C. Kane, MD, PhD; Carmen M. Perez-Terzic, MD, PhD; Ruben J. Crespo-Diaz, PhD; Robert J. McDonald, MD, PhD; Saranya P. Wyles, BS; Jelena Zlatkovic-Lindor, PhD; Timothy J. Nelson, MD, PhD; Andre Terzic, MD, PhD
Journal of the American Heart Association, May 11th, 2015
Exercise Training Reduces PGE2 Levels and Induces Recovery from Steatosis in Tumor-bearing Rats
F. S. Lira, A. Yamashita, L. C. Carnevali Jr, D. C. Gonçalves, W. P. Lima, J. C. Rosa, E. C. Caperuto, L. F. C. Rosa, M. Seelaender
Horm Metab Res 2010; 42(13): 944-949
Neuron-Specific Deletion of Peroxisome Proliferator-Activated Receptor Delta (PPARd) in Mice Leads to Increased Susceptibility to Diet-Induced Obesity
Heidi E. Kocalis, Maxine K. Turney, Richard L. Printz, Gloria N. Laryea, Louis J. Muglia, Sean S. Davies, Gregg D. Stanwood, Owen P. McGuinness, Kevin D. Niswender
Research Article | published 20 Aug 2012 | PLOS ONE 10.1371/journal.pone.0042981
The Effects of C75, an Inhibitor of Fatty Acid Synthase, on Sleep and Metabolism in Mice
Jacob Pellinen, Eva Szentirmai
2012 PLoS ONE 7(2): e30651. doi:10.1371/journal.pone.0030651
Ventilatory pattern and energy expenditure are altered in cystic fibrosis mice
Rebecca J. Darrah, Ilya R. Bederman, Anna L. Mitchell, Craig A. Hodges, Cara K. Campanaro, Mitchell L. Drumm, Frank J. Jacono
Journal of Cystic Fibrosis Available online 3 January 2013
Peripheral-Specific Y2 Receptor Knockdown Protects Mice From High-Fat Diet-Induced Obesity
Yan-chuan Shi, Shu Lin, Lesley Castillo, Aygul Aljanova, Ronaldo F. Enriquez, Amy D. Nguyen, Paul A. Baldock, Lei Zhang, Martijn S. Bijker, Laurence Macia, Ernie Yulyaningsih, Hui Zhang, Jackie Lau, Amanda Sainsbury, Herbert Herzog
Obesity Volume 19, Issue 11, pages 2137-2148, November 2011
Nesfatin-1, corticotropin-releasing hormone, thyrotropin-releasing hormone, and neuronal histamine interact in the hypothalamus to regulate feeding behavior
Koro Gotoh, Takayuki Masaki, Seiichi Chiba, Hisae Ando, Takanobu Shimasaki, Kimihiko Mitsutomi, Kansuke Fujiwara, Isao Katsuragi, Tetsuya Kakuma, Toshiie Sakata, Hironobu Yoshimatsu
Journal of Neurochemistry
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Ncb5or Deficiency Increases Fatty Acid Catabolism and Oxidative Stress
Ming Xu, WenFang Wang, Jennifer R. Frontera, Melanie C. Neely, Jianghua Lu, Daniel Aires, Fong-Fu Hsu, John Turk, Russell H. Swerdlow, Susan E. Carlson and Hao Zhu
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Mitochondrial Anti-Oxidative Capacity Regulates Muscle Glucose Uptake in the Conscious Mouse: Effect of Exercise and Diet
Li Kang, Mary E. Lustig, Jeffrey S. Bonner, Robert S. Lee-Young, Wesley H. Mayes, Freyja D. James, Chien-Te Lin, Christopher G.R. Perry, Ethan J. Anderson, P. Darrell Neufer, and David H. Wasserman
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A potential role for Insulin resistance in experimental pulmonary hypertension
James West, Kevin D. Niswender, Jennifer A. Johnson, Meredith E. Pugh, Linda Gleaves, Joshua P. Fessel and Anna R. Hemnes
ERJ August 30, 2012 erj00303-2012
Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased ER stress
Stanley MH Chan, Ruo-Qiong Sun, Xiao-Yi Zeng, Zi-Heng Choong, Hao Wang, Matthew J Watt and Ji-Ming Ye
Diabetes January 24, 2013, doi: 10.2337/db12-1397
Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance, and hepatosteatosis
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The FASEB Journal
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GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function
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Enhanced peroxissomal β-oxidation is associated with prevention of obesity and glucose intolerance by fish oil-enriched diets
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Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle
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Diabetologia
May 2011, Volume 54, Issue 5, pp 1169-1180
Intracerebroventricular administration of vasoactive intestinal peptide inhibits food intake
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Adropin deficiency is associated with increased adiposity and insulin resistance.
Ganesh Kumar K, Zhang J, Gao S, Rossi J, McGuinness OP, Halem HH, Culler MD, Mynatt RL, Butler AA
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Hydroxypropylated distarch phosphate versus unmodified tapioca starch: fat oxidation and endurance in C57BL/6J mice
Satoshi Haramizu, Akira Shimotoyodome, Daisuke Fukuoka, Takatoshi Murase, Tadashi Hase
European Journal of Applied Physiology
September 2012, Volume 112, Issue 9, pp 3409-3416
Paradoxical Coupling of Triglyceride Synthesis and Fatty Acid Oxidation in Skeletal Muscle Overexpressing DGAT1
Li Liu, Xiaojing Shi, Cheol Soo Choi, Gerald I. Shulman, Katherine Klaus, K. Sreekumaran Nair, Gary J. Schwartz, Yiying Zhang, Ira J. Goldberg and Yi-Hao Yu
Diabetes November 2009 vol. 58 no. 11 2516-2524
Superimposition of Postnatal Calorie Restriction Protects the Aging Male Intrauterine Growth- Restricted Offspring from Metabolic Maladaptations
Yun Dai, Shanthie Thamotharan, Meena Garg, Bo-Chul Shin and Sherin U. Devaskar
Endocrinology September 1, 2012 vol. 153 no. 9 4216-4226
Intracerebroventricular Leptin Infusion Improves Glucose Homeostasis in Lean Type 2 Diabetic MKR Mice via Hepatic Vagal and Non-Vagal Mechanisms
Xiaosong Li, Xhiping Wu, Raul Camacho, Gary J. Schwartz, Derek LeRoith
PLoS ONE 6(2): e17058. doi:10.1371/journal.pone.0017058
Region-specific differences in brain melanocortin receptors in rats of the lean phenotype
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Neuroreport:
11 July 2012 - Volume 23 - Issue 10 - p 596-600
Genetic Defect in Phospholipase Cδ1 Protects Mice From Obesity by Regulating Thermogenesis and Adipogenesis
Masayuki Hirata, Mutsumi Suzuki, Rika Ishii, Reiko Satow, Takafumi Uchida, Tomoya Kitazumi, Tsutomu Sasaki, Tadahiro Kitamura, Hideki Yamaguchi, Yoshikazu Nakamura and Kiyoko Fukami
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Thioesterase superfamily member 2/acyl-CoA thioesterase 13 (Them2/Acot13) regulates hepatic lipid and glucose metabolism
Hye Won Kang, Michele W. Niepel, Shuxin Han, Yuki Kawano and David E. Cohen
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The FASEB Journal
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Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice
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Volume 19, Issue 7, pages 1396-1403, July 2011
Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression
Mardi S. Byerly, Muhannad Al Salayta, Roy D. Swanson, Kiwook Kwon, Jonathan M. Peterson, Zhikui Wei, Susan Aja, Timothy H. Moran, Seth Blackshaw, G. William Wong
European Journal of Neuroscience DOI: 10.1111/ejn.12122
PXR ablation alleviates diet-induced and genetic obesity and insulin resistance in mice
Jinhan He, Jie Gao, Meishu Xu, Songrong Ren, Maja Stefanovic-Racic, Robert M O'Doherty and Wen Xie
Diabetes January 24, 2013
Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity
Masato Asai, Shwetha Ramachandrappa, Maria Joachim, Yuan Shen, Rong Zhang, Nikhil Nuthalapati, Visali Ramanathan, David E. Strochlic, Peter Ferket, Kristen Linhart, Caroline Ho, Tatiana V. Novoselova, Sumedha Garg, Martin Ridderstrale, Claude Marcus, Joel N. Hirschhorn, Julia M. Keogh, Stephen O'Rahilly, Li. F. Chan, Adrian J. Clark, I. Sadaf Farooqi, Joseph A. Majzoub
Science, Vol 341, July 19, 2013 p.275
Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism
Dimitra K. Georgiou, Adan Dagnino-Acosta, Chang Seok Lee, Deric M. Griffin, Hui Wang, William R. Lagor, Robia G. Pautler, Robert T. Dirksen, Susan L. Hamilton
The Journal of Biological Chemistry, 5 August 2015
A new mouse model of metabolic syndrome and associated complications
Yun Wang, Yue Zheng, Patsy M Nishina and Jürgen K Naggert
J Endocrinol July 1, 2009 202 17-28
Organ weight, intestinal morphology, and fasting whole-body oxygen consumption in growing pigs fed diets containing distillers dried grains with solubles alone or in combination with a multienzyme supplement
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J ANIM SCI September 2012 vol. 90 no. 9 3032-3040
Overexpression of FoxO1 in the Hypothalamus and Pancreas Causes Obesity and Glucose Intolerance
Hye-Jin Kim, Masaki Kobayashi, Tsutomu Sasaki, Osamu Kikuchi, Kosuke Amano, Tomoya Kitazumi, Yong-Soo Lee, Hiromi Yokota-Hashimoto, Vina Yanti Susanti, Yukari Ido Kitamura, Jun Nakae and Tadahiro Kitamura
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Oligoclonal Antibody Targeting Ghrelin Increases Energy Expenditure and Reduces Food Intake in Fasted Mice
Joseph S. Zakhari, Eric P. Zorrilla, Bin Zhou, Alexander V. Mayorov, and Kim D. Janda
Mol. Pharmaceutics, 2012, 9 (2), pp 281-289
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Loss of FXR Protects against Diet-Induced Obesity and Accelerates Liver Carcinogenesis in ob/ob Mice
Yanqiao Zhang, Xuemei Ge, Lydia A. Heemstra, Wei-Dong Chen, Jiesi Xu, Joseph L. Smith, Huiyan Ma, Neda Kasim, Peter A. Edwards and Colleen M. Novak
Molecular Endocrinology February 1, 2012 vol. 26 no. 2 272-280
Effect of Age on Protein Conservation during Very-Low-Energy Diet in Obese Sprague-Dawley Rats
Julia A. Johnson, Choon-Hie Yu, Mei-Uih Yang, F. Xavier Pi-Sunyer
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Volume 6, Issue 6, pages 448-457, November 1998
Gsα Deficiency in the Paraventricular Nucleus of the Hypothalamus Partially Contributes to Obesity Associated with Gs? Mutations
Min Chen, Alta Berger, Ahmed Kablan, Jiandi Zhang, Oksana Gavrilova and Lee S. Weinstein
Endocrinology September 1, 2012 vol. 153 no. 9 4256-4265
Methazolamide Is a New Hepatic Insulin Sensitizer That Lowers Blood Glucose In Vivo
Nicky Konstantopoulos, Juan C. Molero, Sean L. McGee, Briana Spolding, Tim Connor, Melissa de Vries, Stephen Wanyonyi, Richard Fahey, Shona Morrison, Courtney Swinton, Sharon Jones, Adrian Cooper, Lucia Garcia-Guerra, Victoria C. Foletta, Guy Krippner, Sofianos Andrikopoulos and Ken R. Walder
Diabetes August 2012 vol. 61 no. 8 2146-2154
Coordination of the transcriptome and metabolome by the circadian clock
Kristin L. Eckel-Mahan, Vishal R. Patel, Robert P. Mohney, Katie S. Vignola, Pierre Baldi, and Paolo Sassone-Corsi
PNAS April 3, 2012 vol. 109 no. 14 5541-5546
Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice
Jorge Joven, Eugenia Espinel, Anna Rull, Gerard Aragonès, Esther RodrÃguez-Gallego, Jordi Camps, Vicente Micol, MarÃa Herranz-López, Javier A. Menéndez, Isabel Borrás, Antonio Segura-Carretero, Carlos Alonso-Villaverde, Raul Beltran-Debon
Biochimica et Biophysica Acta (BBA) - General Subjects
Volume 1820, Issue 7, July 2012, Pages 894-899
Sustained torpidity following multi-dose administration of 3-iodothyronamine in mice
Hyunwoo Ju, Hyekyoung So, Kyungbong Ha, Kyoungsook Park, Ju-Woon Lee, Chan-Moon Chung, Inho Choi
Journal of Cellular Physiology
Volume 226, Issue 4, pages 853-858, April 2011
Importance of adult Dmbx1 in long-lasting orexigenic effect of agouti-related peptide
Seiichiro Hirono, Eun Young Lee, Shunsuke Kuribayashi, Takahiro Fukuda, Naokatsu Saeki, Yasuhiko Minokoshi, Toshihiko Iwanaga, Takashi Miki
Endocrinology, 23 October 2015
Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys
Haruka Okamoto, Jinrang Kim, JohnPaul Aglione, Joseph Lee, Katie Cavino, Erqian Na, Ashique Rafique, Jee Hae Kim, Joyce Harp, David M. Valenzuela, George D. Yancopoulos, Andrew J. Murphy, Jesper Gromada
Endocrinology, May 2015
Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target
Xiao-Yi Zeng, Hao Wang, Fang Bai, Xiu Zhou, Song-Pei Li, Lu-Ping Ren, Ruo-Qiong Sun, Charlie CL Xue, Hua-Liang Jiang, Li-Hong Hu, and Ji-Ming Ye
British Journal of Pharmacology, 2015
The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing
Sandra G. Gonzalez Malagon, Anna N. Melidoni, Diana Hernandez, Bilal A. Omar, Lyndsey Houseman, Sunil Veeravalli, Flora Scott, Dorsa Varshavi, Jeremy Everett, Yugo Tsuchiya, John F. Timms, Ian R. Phillips, Elizabeth A. Shepharda
Biochemical Pharmacology, 4 June 2015
Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex
Ganesh Kolumam, Mark Z. Chen, Raymond Tong, Jose Zavala-Solorio, Lance Kates, Nicholas van Bruggen, Jed Ross, Shelby K. Wyatt, Vineela D. Gandham, Richard A.D. Carano, Diana Ronai Dunshee, Ai-Luen Wu, Benjamin Haley, Keith Anderson, Søren Warming, Xin Y. Rairdan, Nicholas Lewin-Koh, Yingnan Zhang, Johnny Gutierrez, Amos Baruch, Thomas R. Gelzleichter, Dale Stevens, Sharmila Rajan, Travis W. Bainbridge, Jean-Michel Vernes, Y. Gloria Meng, James Ziai, Robert H. Soriano, Matthew J. Brauer, Yongmei Chen
EBioMedicine, 30 May 2015
Uncoupling protein-1 is protective of bone mass under mild cold stress conditions
Amy D. Nguyen, Nicola J. Lee, Natalie K.Y. Wee, Lei Zhang, Ronaldo F. Enriquez, Ee Cheng Khor, Tao Nie, Donghai Wu, Amanda Sainsbury, Paul A. Baldock, Herbert Herzoga
Bone, 5 June 2015
Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism
Shawna E. Wicks, Bolormaa Vandanmagsar, Kimberly R. Haynie, Scott E. Fuller, Jaycob D. Warfel, Jacqueline M. Stephens, Miao Wang, Xianlin Han, Jingying Zhang, Robert C. Noland, and Randall L. Mynatt
Proceedings of the National Academy of Sciences of the United States of America, 8 June 2015
Dietary Sodium Suppresses Digestive Efficiency via the Renin-Angiotensin System
Benjamin J. Weidemann, Susan Voong, Fabiola I. Morales-Santiago, Michael Z. Kahn, Jonathan Ni, Nicole K. Littlejohn, Kristin E. Claflin, Colin M.L. Burnett, Nicole A. Pearson, Michael L. Lutter, and Justin L. Grobe
Scientific Reports, Vol. 5, Article Number 11123, 11 June 2015
Furostanolic saponins from Trigonella Foenum-Graecum alleviates diet-induced glucose intolerance and hepatic fat accumulation
Yinan Hua, Sidney Y Ren, Rui Guo, Olivia Rogers, Rama P. Nair, Debasis Bagchi, Anand Swaroop, andSreejayan Nair
Molecular Nutrition & Food Research, July 2015
Skeletal muscle ACC2 S212 phosphorylation is not required for the control of fatty acid oxidation during exercise
Hayley M. O'Neill, James S. Lally, Sandra Galic, Thomas Pulinilkunnil, Rebecca J. Ford, Jason R. B. Dyck, Bryce J. van Denderen, Bruce E. Kemp, Gregory R. Steinberg
Physiological Reports, Vol. 3 No. e12444, 8 July 2015
Lipid transport in cholecystokinin knockout mice
Alexandra King, Qing Yang, Sarah Huesman, Therese Rider, Chunmin C. Lo
Physiology & Behavior, 11 July 2015
C-reactive Protein Causes Insulin Resistance in Mice Through Fcγ Receptor IIB–Mediated Inhibition of Skeletal Muscle Glucose Delivery
Keiji Tanigaki, Wanpen Vongpatanasin, Jose A. Barrera, Dmitriy N. Atochin, Paul L. Huang, Ezio Bonvini, Philip W. Shaul and Chieko Mineo
Diabetes October 15, 2012
Combinatorial gene construct and non-viral delivery for anti-obesity in diet-induced obese mice
Hongsuk Park, Sungpil Cho, Yong Hwan Han, Margit M. Janat-Amsbury, Sihem Boudina, You Han Bae
Journal of Controlled Release, 25 March 2015
Adipose triglyceride lipase (ATGL) deletion from adipocytes, but not skeletal myocytes, impairs acute exercise performance in mice
John J Dube , Mitch T. Sitnick , Gabriele Schoiswohl , Rachel C Wills , Mahesh K Basantani , Lingzhi Cai , Thomas Pulinilkunnil , Erin E. Kershaw
American Journal of Physiology - Endocrinology and Metabolism Published 17 March 2015 Vol. no. , DOI: 10.1152/ajpendo.00530.2014
Synergistic effects of leucine and resveratrol on
insulin sensitivity and fat metabolism in
adipocytes and mice
Antje Bruckbauer, Michael B Zemel, Teresa Thorpe, Murthy R Akula, Alan C Stuckey, Dustin Osborne, Stephen Kennel and Jonathan S Wall
Nutrition & Metabolism 2012, 9:77
A Novel Nociceptin Receptor Antagonist LY2940094 Inhibits Excessive Feeding Behavior in Rodents: A Possible Mechanism For The Treatment of Binge Eating Disorder
Michael A. Statnick, Yanyun Chen, Michael Ansonoff, Jeffrey M. Witkin, Linda Rorick-Kehn, Todd M. Suter, Min Song, Charlie Hu, Celia Lafuente, Alma Jimenez, Ana Benito, Nuria Diaz, Maria Angeles Martinez-Grau, Miguel Toledo, John E. Pintar
The Journal of Pharmacology and Experimental Therapeutics, 9 December 2015
Prohibitin/annexin 2 interaction regulates fatty acid transport in adipose tissue
Ahmad Salameh, Alexes C. Daquinag, Daniela I. Staquicini, Zhiqiang An, Katherine A. Hajjar, Renata Pasqualini, Wadih Arap, Mikhail G. Kolonin
JCI Insight, Vol. 1, Issue 10, 7 July 2016
Creatine transporter deficiency leads to increased whole body and cellular metabolism
Marla K. Perna, Amanda N. Kokenge, Keila N. Miles, Kenea C. Udobi, Joseph F. Clark, Gail J. Pyne-Geithman, Zaza Khuchua, Matthew R. Skelton
Amino Acids, Vol. 48, Issue 8, Pages 2057-2065, August 2016
Yhhu981, a novel compound, stimulates fatty acid oxidation via the activation of AMPK and ameliorates lipid metabolism disorder in ob/ob mice
Hong-liang Zeng, Su-ling Huang, Fu-chun Xie, Li-min Zeng, You-hong Hu and Ying Leng
Acta Pharmacologica Sinica (2015) 36: 343-352; doi: 10.1038/aps.2014.147
Maximal Oxidative Capacity during Exercise Is Associated with Skeletal Muscle Fuel Selection and Dynamic Changes in Mitochondrial Protein Acetylation
Katherine A. Overmyer, Charles R. Evans, Nathan R. Qi, Catherine E. Minogue, Joshua J. Carson, Christopher J. Chermside-Scabbo, Lauren G. Koch, Steven L. Britton, David J. Pagliarini, Joshua J. Coon, Charles F. Burant
Cell Metabolism, Volume 21, Issue 3, 3 March 2015, Pages 468-478
GGCX and VKORC1 inhibit osteocalcin endocrine functions
Mathieu Ferron, Julie Lacombe, Amélie Germain, Franck Oury, and Gerard Karsenty
JCB, March 9, 2015
Disruption of KATP channel expression in skeletal muscle by targeted oligonucleotide delivery promotes activity-linked thermogenesis
Siva Rama Krishna Koganti, Zhiyong Zhu, Ekaterina Subbotina, Zhan Gao, Ana Sierra, Manuel Proenza, Liping Yang, Alexey Alekseev, Denice Hodgson-Zingman, Leonid Zingman
Molecular Therapy accepted article preview online 04 February 2015; doi:10.1038/mt.2015.21
The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β
Hidetoshi Fujita, Naoko Yagishita, Satoko Aratani, Tomoko Saito-Fujita, Saori Morota, Yoshihisa Yamano, Magnus J Hansson, Masato Inazu, Hiroko Kokuba, Katsuko Sudo, Eiichi Sato, Ko-ichi Kawahara, Fukami Nakajima, Daisuke Hasegawa, Itsuro Higuchi, Tomoo Sato, Natsumi Araya, Chie Usui, Kenya Nishioka, Yu Nakatani, Ikuro Maruyama, Masahiko Usui, Naomi Hara, Hiroyuki Uchino, Eskil Elmer, Kusuki Nishioka, Toshihiro Nakajima
The EMBO Journal (2015) embj.201489897
Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis
Parjam Zolfaghari , Jane E Carre , Nadeene Parker , Nancy A. Curtin , Michael R Duchen , Mervyn Singer
American Journal of Physiology - Endocrinology and Metabolism Published 24 February 2015 Vol. no. , DOI: 10.1152/ajpendo.00562.2014
Cardiac adaptations from 4 weeks of intensity-controlled vigorous exercise are lost after a similar period of detraining
Cheryl D. Waring , Beverley J. Henning , Andrew J. Smith , Bernardo Nadal-Ginard , Daniele Torella , Georgina M. Ellison
Physiological Reports Published 23 February 2015 Vol. 3 no. e12302 DOI: 10.14814/phy2.12302
Thermogenic capacity is antagonistically regulated in classical brown and white subcutaneous fat depots by high-fat diet and endurance training in rats: Impact on whole-body energy expenditure
Michelle V. Wu, George Bikopoulos, Steven Hung, Rolando B. Ceddia
The Journal of Biological Chemistry, 289, 34129-34140. Dec. 5, 2014
Estradiol Improves Right Ventricular Function In Rats With Severe Angioproliferative Pulmonary Hypertension: Effects Of Endogenous And Exogenous Sex Hormones
Andrea L Frump , Kara N. Goss , Alexandra Vayl , Marjorie Albrecht , Amanda Jo Fisher , Roziya Tursunova , John Fierst , Jordan Whitson , Anthony R Cucci , Mary Beth Brown , Tim Lahm
American Journal of Physiology - Lung Cellular and Molecular Physiology Published 20 February 2015 Vol. no. , DOI: 10.1152/ajplung.00006.2015
EXERCISE TRAINING AT MILD RELATIVE EXERCISE INTENSITY DOES NOT ATTENUATE DISEASE PROGRESSION IN A RAT MODEL OF SEVERE PULMONARY ARTERIAL HYPERTENSION.
Harper, Ron; Weyer, Josh; Bremer, Brent; Cooney, Sean; Fisher, Amanda; Presson, Robert; Lahm, Tim; Petrache, Irina; Brown, Mary Beth
Cardiopulmonary Physical Therapy Journal, December 2014 - Volume 25 - Issue 4 - p 131-132
Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα
Roozbeh Aschar-Sobbi, Farzad Izaddoustdar, Adam S. Korogyi, Qiongling Wang, Gerrie P. Farman, FengHua Yang, Wallace Yang, David Dorian, Jeremy A. Simpson, Jari M. Tuomi, Douglas L. Jones, Kumaraswamy Nanthakumar, Brian Cox, Xander H. T. Wehrens, Paul Dorian & Peter H. Backx
Nature Communications 6, Article number: 6018 doi:10.1038/ncomms7018
The phenotype of a flavincontaining
monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance
Veeravalli S, Omar BA, Houseman L, Hancock M, Malagon SGG, Scott F, Janmohamed A, Phillips IR, Shephard EA
Biochemical Pharmacology (2014),
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Atypical Antipsychotics Rapidly and Inappropriately Switch Peripheral Fuel Utilization to Lipids, Impairing Metabolic Flexibility in Rodents
Vance L. Albaugh, Thomas C. Vary, Olga Ilkayeva, Brett R. Wenner, Kevin P. Maresca, John L. Joyal, Steven Breazeale, Tedd D. Elich, Charles H. Lang and Christopher J. Lynch
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Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacity
Colleen M. Novaka, Carlos Escande, Paul R. Burghardt, Minzhi Zhang, Maria Teresa Barbosa, Eduardo N. Chini, Steven L. Britton, Lauren G. Koch, Huda Akil and James A. Levine
Hormones and Behavior Volume 58, Issue 3, August 2010, Pages 355-367
PPARα via HNF4α regulates the expression of genes encoding hepatic amino acid catabolizing enzymes to maintain metabolic homeostasis
Alejandra V. Contreras, Claudia Rangel-Escareno, Nimbe Torres, Gabriela Aleman-Escondrillas, Victor Ortiz, Lilia G. Noriega, Ivan Torre-Villalvazo, Omar Granados, Laura A. Velazquez-Villegas, Sandra Tobon-Cornejo, Diana Gonzalez-Hirschfeld, Felix Recillas-Targa, Elizabeth Tejero-Barrera, Frank J. Gonzalez, Armando R. Tovar
Genes & Nutrition, January 2015, 10:3
TNF-related apoptosis-inducing ligand significantly attenuates metabolic abnormalities in high-fat-fed mice reducing adiposity and systemic inflammation
Stella Bernard, Giorgio Zauli, Christos Tikellis, Riccardo Candido, Bruno Fabris, Paola Secchiero, Mark E. Cooper, and Merlin C. Thomas
Clinical Science (2012) 123, 00-00 doi:10.1042/CS20120176
Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice
Harini Sampath, Ayesha K. Batra, Vladimir Vartanian, J. Russ Carmical, Deborah Prusak, Irena B. King, Brian Lowell, Lauriel F. Earley, Thomas G. Wood, Daniel L. Marks, Amanda K. McCullough, and Lloyd R. Stephen
AJP - Endo April 1, 2011 vol. 300 no. 4 E724-E734
Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys
Haijun D. Sun, Maria Malabunga, James R. Tonra, Roberto DiRenzo, Francine E. Carrick, Huiyuan Zheng, Hans-Rudolf Berthoud, Owen P. McGuinness, Juqun Shen, Peter Bohlen, Rudolph L. Leibel and Paul Kussie
Am J Physiol Endocrinol Metab 292:E964-E976, 2007
A Novel Therapeutic Approach to Treating Obesity through Modulation of TGF? Signaling
Alan Koncarevic, Shingo Kajimura, Milton Cornwall-Brady, Amy Andreucci, Abigail Pullen, Dianne Sako, Ravindra Kumar, Asya V. Grinberg, Katia Liharska, Jeffrey A. Ucran, Elizabeth Howard, Bruce M. Spiegelman, Jasbir Seehra and Jennifer Lachey
Endocrinology July 1, 2012 vol. 153 no. 7 3133-3146
Influence of dark phase restricted high fat feeding on myocardial adaptation in mice
Ju-Yun Tsai, Carolina Villegas-Montoya, Brandon B. Boland, Zachary Blasier, Oluwaseun Egbejimi, Raquel Gonzalez, Michael Kueht, Tracy A. McElfresh, Rachel A. Brewer, Margaret P. Chandler, Molly S. Bray, Martin E. Young
Journal of Molecular and Cellular Cardiology
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Genetic control of ATGL-mediated lipolysis modulates adipose triglyceride stores in leptin-deficient mice
Genevieve Marcelin, Shun-Mei Liu, Xiaosong Li, Gary J. Schwartz and Streamson Chua
May 2012 The Journal of Lipid Research, 53, 964-972.
Diacylglycerol lipase a knockout mice demonstrate metabolic and behavioral phenotypes similar to those of cannabinoid receptor 1 knockout mice
David R Powell, Jason P Gay, Nathaniel Wilganowski, Deon Doree, Katerina V Savelieva, Thomas H Lanthorn, Robert Read, Peter Vogel, Gwenn M Hansen, Robert Brommage, Zhi-Ming Ding, Urvi Desai and Brian Zambrowicz
Frontiers in Endocrinology, 12 May 2015
ACE2 deficiency shifts energy metabolism towards glucose utilization
Stella Bernardi, Christos Tikellis, Riccardo Candido, Despina Tsorotes, Raelene J. Pickering, Fleur Bossi, Renzo Carretta, Bruno Fabris, Mark E. Cooper, Merlin C. Thomas
Metabolism - Clinical and Experimental, November 20, 2014
Adipose tissue lipolysis and energy metabolism in early cancer cachexia in mice
Kara L. Kliewer, Jia-Yu Ke, Min Tian, Rachel M. Cole, Rebecca R. Andridge & Martha A. Belury
Cancer Biology & Therapy, 02 Dec 2014, DOI: 10.4161/15384047.2014.987075
The suppression of ghrelin signaling mitigates age-associated thermogenic impairment Â
Ligen Lin, Jong Han Lee, Odelia Y. N. Bongmba, Xiaojun Ma, Xiongwei Zhu, David Sheikh?Hamad, and Yuxiang Sun
AGING, November 2014, Vol 6, N 11
Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes
David A. Griffith , Daniel W. Kung , William P. Esler , Paul A. Amor , Scott W. Bagley , Carine Beysen , Santos Carvajal-Gonzalez , Shawn D. Doran , Chris Limberakis , Alan M Mathiowetz , R. Kirk McPherson , David A. Price , Eric Ravussin , Gabriele E. Sonnenberg , James A. Southers , Laurel J. Sweet , Scott M. Turner , and Felix F. Vajdos
J. Med. Chem., November 25, 2014, DOI: 10.1021/jm5016022
Compensatory elevation of voluntary activity in mouse mutants with impaired mitochondrial energy metabolism
Jerome Lapointe , Bryan G. Hughes , Eve Bigras , Siegfried Hekimi
Physiological ReportsPublished 20 November 2014Vol. 2no. e12214DOI: 10.14814/phy2.12214
Experimental immunology Diet-induced obesity mediates a proinflammatory response in pancreatic β cell via toll-like receptor 4
Juan Li, Shufen Chen, Juan Qiang, Xin Wang, Lei Chen, Dajin Zou
Centr Eur J Immunol 2014; 39 (3): 306-315
Depletion of white adipocyte progenitors induces beige adipocyte differentiation and suppresses obesity development
A C Daquinag, C Tseng, A Salameh, Y Zhang, F Amaya-Manzanares, A Dadbin, F Florez, Y Xu, Q Tong and M G Kolonin
Cell Death and Differentiation, 24 October 2014; doi: 10.1038/cdd.2014.148
Impairment of vesicular ATP release affects glucose metabolism and increases insulin sensitivity
Shohei Sakamoto, Takaaki Miyaji, Miki Hiasa, Reiko Ichikawa, Akira Uematsu, Ken Iwatsuki, Atsushi Shibata, Hisayuki Uneyama, Ryoichi Takayanagi, Akitsugu Yamamoto, Hiroshi Omote, Masatoshi Nomura & Yoshinori Moriyama
Scientific Reports 4, Article number: 6689, Oct. 2014, doi:10.1038/srep06689
DLK1/PREF1 regulates nutrient metabolism and protects from steatosis
Marika Charalambous, Simao Teixeira Da Rocha, Elizabeth Jane Radford, Gema Medina-Gomez, Scott Curran, Scarlett B. Pinnock, Sacri R. Ferrón, Antonio Vidal-Puig, and Anne C. Ferguson-Smith
PNAS October 27, 2014
Dnmt3a in Sim1 Neurons Is Necessary for Normal Energy Homeostasis
Daisuke Kohno, Syann Lee, Matthew J. Harper, Ki Woo Kim, Hideyuki Sone, Tsutomu Sasaki, Tadahiro Kitamura, Guoping Fan, and Joel K. Elmquist
The Journal of Neuroscience, 12 November 2014, 34(46): 15288-15296; doi: 10.1523/JNEUROSCI.1316-14.2014
Alpha-lipoic acid increases energy expenditure by enhancing AMPK-PGC-1α signalling in the skeletal muscle of aged mice
Yi Wang, Xiaojie Li, Yuming Guo, Lawrence Chan, and Xinfu Guan
Metabolism. 2010 July; 59(7): 967-976.
Chronic AMP-kinase activation with AICAR reduces adiposity by remodeling adipocyte metabolism and increasing leptin sensitivity
Mandeep P. Gaidhu, Andrea Frontini, Steven Hung, Kathryn Pistor, Saverio Cinti and Rolando B. Ceddia
September 2011 The Journal of Lipid Research, 52, 1702-1711.
Loss of Coiled-Coil Domain Containing 80 Negatively Modulates Glucose Homeostasis in Diet-Induced Obese Mice
Frédéric Tremblay, Christine Huard, Jessie Dow, Tiffany Gareski, Sarah Will, Ann-Marie Richard, Jameel Syed, Steven Bailey, Karrie A. Brenneman, Robert V. Martinez, Mylène Perreault, Qingcong Lin and Ruth E. Gimeno
Endocrinology September 1, 2012 vol. 153 no. 9 4290-4303
Deletion of the alpha-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity
William A. Chutkow, Andreas L. Birkenfeld, Jonathan D. Brown, Hui-Young Lee, David W. Frederick, Jun Yoshioka, Parth Patwari, Romy Kursawe, Samuel W. Cushman, Jorge Plutzky, Gerald I. Shulman, Varman T. Samuel and Richard T. Lee
Diabetes June 2010 vol. 59 no. 6 1424-1434
Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo
Greg C. Smith, Wee Kiat Ong, Gordon W. Rewcastle, Jackie D. Kendall, Weiping Han, and Peter R. Shepherd
Biochem J. 2012 February 15; 442(Pt 1): 161-169.
Acute Metabolic Effects of Olanzapine Depend on Dose and Injection Site
Candice M. Klingerman, Michelle E. Stipanovic, Andras Hajnal, Christopher J. Lynch
Dose-Response, Vol. 13, No. 4, 29 November 2015
Long-term dietary supplementation with saury oil attenuates metabolic abnormalities in mice fed a high-fat diet: combined beneficial effect of omega-3 fatty acids and long-chain monounsaturated fatty acids
Zhi-Hong Yang, Seika Inoue, Yasuko Taniguchi, Hiroko Miyahara, Yusuke Iwasaki, Jiro Takeo, Hiroshi Sakaue, Yutaka Nakaya
Lipids in Health and Disease, 1 December 2015
Subcongenic analysis of tabw2 obesity QTL on mouse chromosome 6
Taryn P Stewart, Xia Mao, Maha N Aqqad, Deon Uffort, Kristy D Dillon, Arnold M Saxton and Jung H Kim
BMC Genetics 2012, 13:81 doi:10.1186/1471-2156-13-81
Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3
Tizhong Shan, Yan Xiong, Pengpeng Zhang, Zhiguo Li, Qingyang Jiang, Pengpeng Bi, Feng Yue, Gongshe Yang, Yizhen Wang, Xiaoqi Liu, Shihuan Kuang
Nature Communications, Vol. 7, 27 July 2016
Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice
Hyae-Ran Byuna, Dong-Kyu Kima, Jae-Young Koh
Neurobiology of Disease
Volume 44, Issue 1, October 2011, Pages 125-132
Orally administered [14C]DPA and [14C]DHA are metabolised differently to [14C]EPA in rats
Gunveen Kaura, Juan C. Molero, Harrison S. Weisinger and Andrew J. Sinclair
British Journal of Nutrition / Volume 109 / Issue 03 / February 2013, pp 441-448
Metabolic adaptations to early life protein restriction differ by offspring sex and post-weaning diet in the mouse
K.W. Whitaker, K. Totoki, T.M. Reyes
Nutrition, Metabolism and Cardiovascular Diseases
Volume 22, Issue 12, December 2012, Pages 1067-1074
Chronic injection of pansomatostatin agonist ODT8-SST differentially modulates food intake and decreases body weight gain in lean and diet-induced obese rats
Andreas Stengel, Tamer Coskun, Miriam Goebel-Stengel, Libbey S. Craft, Jorge Alsina-Fernandez, Lixin Wang, Jean Rivier, Yvette Tache
Regulatory Peptides
Volume 167, Issues 2-3, 11 April 2011, Pages 201-208
The role of sodium-coupled glucose co-transporter 3 in the satiety effect of portal glucose sensing
Fabien Delaere, Adeline Duchampt, Lourdes Mounien, Pascal Seyer, Celine Duraffourd, Carine Zitoun, Bernard Thorens, Gilles Mithieux
Molecular Metabolism
Available online 7 December 2012
Suppressed cellular oscillations in After-hours mutant mice are associated with enhanced circadian phase-resetting
Clare Guilding†, Fiona Scott†, David A. Bechtold, Timothy M. Brown, Sven Wegner, Hugh D. Piggins
The Journal of Physiology, DOI: 10.1113/jphysiol.2012.242198
Obesity and Overfeeding Affecting Both Tumor and Systemic Metabolism Activates the Progesterone Receptor to Contribute to Postmenopausal Breast Cancer
Erin D. Giles, Elizabeth A. Wellberg, David P. Astling, Steven M. Anderson, Ann D. Thor, Sonali Jindal, Aik-Choon Tan, Pepper S. Schedin, and Paul S. MacLean
Cancer Res December 15, 2012 72; 6490
Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese–diabetic mice
Tsuyoshi Goto, Aki Teraminami, Joo-Young Lee, Kana Ohyama, Kozue Funakoshi, Young-Il Kim, Shizuka Hirai, Taku Uemura, Rina Yu, Nobuyuki Takahashi, Teruo Kawada
The Journal of Nutritional Biochemistry
Volume 23, Issue 7, July 2012, Pages 768-776
Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice
Zhong Q. Wang, Xian H. Zhang, Yongmei Yu, Alexander. Poulev, David Ribnicky, Z. Elizabeth Floyd, William T. Cefalu
The Journal of Nutritional Biochemistry
Volume 22, Issue 11, November 2011, Pages 1064-1073
The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity
David A. Buchner, Jon M. Geisinger, Patricia A. Glazebrook, Michael G. Morgan, Sabrina H. Spiezio, Karl J. Kaiyala, Michael W. Schwartz, Takeshi Sakurai, Andrew J. Furley, Diana L. Kunze, Colleen M. Croniger, Joseph H. Nadeau
Mammalian Genome
August 2012, Volume 23, Issue 7-8, pp 431-442
MELANOCORTIN ANTAGONISM AMELIORATES MUSCLE WASTING AND INFLAMMATION IN CHRONIC KIDNEY DISEASE
Wai Wilson Cheung and Robert H. K. Mak
AJP - Renal Physiol August 22, 2012 ajprenal.00341.2012
TNF-related apoptosis-inducing ligand significantly attenuates metabolic abnormalities in high-fat-fed mice reducing adiposity and systemic inflammation
Stella Bernardi, Giorgio Zauli, Christos Tikellis, Riccardo Candido, Bruno Fabris, Paola Secchiero, Mark E. Cooper and Merlin C. Thomas
Clinical Science (2012) 123, (547-555)
Activation of Thermogenesis in Brown Adipose Tissue and Dysregulated Lipid Metabolism Associated with Cancer Cachexia in Mice
Maria Tsoli, Melissa Moore, Dominic Burg, Arran Painter, Ryland Taylor, Sarah H. Lockie, Nigel Turner, Alessandra Warren, Greg Cooney, Brian Oldfield, Stephen Clarke, and Graham Robertson
Cancer Res September 1, 2012 72; 4372
Behavioral responses to orexin, orexin receptor gene expression and intrinsic physical activity contribute to individual sensitivity to obesity
Claudio E Perez-Leighton, Kelsey Boland, Jennifer A Teske, Charles Billington, and Catherine M. Kotz
AJP - Endo July 24, 2012 ajpendo.00119.2012
Delayed Puberty but Normal Fertility in Mice With Selective Deletion of Insulin Receptors From Kiss1 Cells
Xiaoliang Qiu, Abigail R. Dowling, Joseph S. Marino, Latrice D. Faulkner, Benjamin Bryant, Jens C. Brüning, Carol F. Elias and Jennifer W. Hill
Endocrinology February 7, 2013 en.2012-2056
Differing Endoplasmic Reticulum Stress Response to Excess Lipogenesis versus Lipid Oversupply in Relation to Hepatic Steatosis and Insulin Resistance
Lu-Ping Ren, Stanley M. H. Chan, Xiao-Yi Zeng, D. Ross Laybutt, Tristan J. Iseli, Ruo-Qiong Sun, Edward W. Kraegen, Gregory J. Cooney, Nigel Turner, Ji-Ming Ye
2012 PLoS ONE 7(2): e30816. doi:10.1371/journal.pone.0030816
High-glycemic index carbohydrates abrogate the antiobesity effect of fish oil in mice
Qin Hao, Haldis H. Lillefosse, Even Fjare, Lene Secher Myrmel, Lisa K. Midtbo, Ragnhild H. Jarlsby, Tao Ma, Bingbing Jia, Rasmus K. Petersen, Si B. Sonne, André Chwalibog, Livar Frøyland, Bjørn Liaset, Karsten Kristiansen and Lise Madsen
Am J Physiol Endocrinol Metab 302:E1097-E1112, 2012. First published 14 February 2012
Rhein Protects against Obesity and Related Metabolic Disorders through Liver X Receptor-Mediated Uncoupling Protein 1 Upregulation in Brown Adipose Tissue
Xiaoyan Sheng, Xuehua Zhu, Yuebo Zhang, Guoliang Cui, Linling Peng, Xiong Lu, and Ying Qin Zang
Int J Biol Sci. 2012; 8(10): 1375-1384.
Dietary Cholecalciferol and Calcium Levels in a Western-Style Defined Rodent Diet Alter Energy Metabolism and Inflammatory Responses in Mice
Claire C. Bastie, Erin Gaffney-Stomberg, Ting-Wen A. Lee, Elena Dhima, Jeffrey E. Pessin, and Leonard H. Augenlicht
J. Nutr. May 1, 2012 vol. 142 no. 5 859-865
Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation and atherosclerosis in Ldlr-/- mice
Julia M. Assini, Erin E. Mulvihill, Brian G. Sutherland, Dawn E. Telford, Cynthia G. Sawyez, Sarah L. Felder, Sanjiv S. Chhoker, Jane Y. Edwards, Robert Gros and Murray W. Huff
The Journal of Lipid Research, jlr.M032631.
FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents
James Mu, Jason Pinkstaff, Zhihua Li, Lillian Skidmore, Nina Li, Heather Myler, Qing Dallas-Yang, Anna-Maria Putnam, Jun Yao, Stuart Bussell, Margaret Wu, Thea C. Norman, Carlos G. Rodriguez, Bruce Kimmel, Joseph M. Metzger, Anthony Manibusan, Darin Lee, Dennis M. Zaller, Bei B. Zhang, Richard D. DiMarchi, Joel P. Berger and Douglas W. Axelrod
Diabetes February 2012 vol. 61 no. 2 505-512
Loss of Adipose Fatty Acid Oxidation Does Not Potentiate Obesity at Thermoneutrality
Jieun Lee, Joseph Choi, Susan Aja, Susanna Scafidi, Michael J. Wolfgang
Cell Reports, Vol. 14, Issue 6, Pages 1308-1316, 16 February 2016
Effect of Housing Types on Growth, Feeding, Physical Activity, and Anxiety-Like Behavior in Male Sprague-Dawley Rats
Jennifer A. Teske,Claudio Esteban Perez-Leighton, Emily E. Noble, Chuanfeng Wang,Charles J. Billington, Catherine M. Kotz
Frontiers in Nutrition, 4 February 2016
Autonomic nervous system-mediated effects of galanin-like peptide on lipid metabolism in liver and adipose tissue
Satoshi Hirako, Nobuhiro Wada, Haruaki Kageyama, Fumiko Takenoya, Yoshihiko Izumida, Hyounju Kim, Yuzuru Iizuka, Akiyo Matsumoto, Mai Okabe, Ai Kimura, Mamiko Suzuki, Satoru Yamanaka, Seiji Shioda
Scientific Reports, Vol. 6, Number 21481, 19 February 2016
Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease
Vikram Shettigar, Bo Zhang, Sean C. Little, Hussam E. Salhi, Brian J. Hansen, Ning Li, Jianchao Zhang, Steve R. Roof, Hsiang-Ting Ho, Lucia Brunello, Jessica K. Lerch, Noah Weisleder, Vadim V. Fedorov, Federica Accornero, Jill A. Rafael-Fortney, Sandor Gyorke, Paul M. L. Janssen, Brandon J. Biesiadecki, Mark T. Ziolo, Jonathan P. Davis
Nature Communications, Vol. 7, 24 February 2016
Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats
Geraldine Harrimana, Jeremy Greenwoodb, Sathesh Bhatb, Xinyi Huangc, Ruiying Wangd, Debamita Pauld, Liang Tongd, Asish K. Sahae, William F. Westlina, Rosana Kapellera, H. James Harwood Jr.
PNAS, Vol. 113, no. 13, 29 March 2016
Male Presence can Increase Body Mass and Induce a Stress-Response in Female Mice Independent of Costs of Offspring Production
Michael Garratt, Anthony J. Kee, Rupert Palme, Robert C. Brooks
Scientific Reports, 23 March 2016
Temperature dependence of the control of energy homeostasis requires CART signaling
Jackie Lau, Yan-Chuan Shi, Herbert Herzog
Neuropeptides, 5 April 2016
Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet
Mikael Bjursell, Therése Admyre, Melker Göransson, Anna E. Marley, David M. Smith, Jan Oscarsson, and Mohammad Bohlooly
AJP - Endo January 2011 vol. 300 no. 1 E211-E220
Mice Lacking Hepatic Lipase Are Lean and Protected against Diet-Induced Obesity and Hepatic Steatosis
Harvey K. Chiu, Kun Qian, Kayoko Ogimoto, Gregory J. Morton, Brent E. Wisse, Nalini Agrawal, Thomas O. McDonald, Michael W. Schwartz and Helén L. Dichek
Endocrinology Vol. 151, No. 3 993-1001
High levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity
Sjoerd AA van den Berg, Bruno Guigas, Silvia Bijland, Margriet Ouwens, Peter J Voshol, Rune R Frants, Louis M Havekes, Johannes A Romijn, Ko Willems van Dijk
Nutrition & Metabolism 2010, 7:24
Antiobesity Effect of MK-5046, a Novel Bombesin Receptor Subtype-3 Agonist
Xiao-Ming Guan, Joseph M. Metzger, Liming Yang, Kate A. Raustad, Sheng-Ping Wang, Stephanie K. Spann, Jennifer A. Kosinski, Hong Yu, Lauren P. Shearman, Terry D. Faidley1, Oksana Palyha, Yanqing Kan, Theresa M. Kelly, Iyassu Sebhat, Linus S. Lin, Jasminka Dragovic, Kathy A. Lyons, Stephanie Craw, Ravi P. Nargund, Donald J. Marsh, Alison M. Strack and Marc L. Reitman
JPET February 2011 vol. 336 no. 2 356-364
A Novel Rodent Model That Mimics the Metabolic Sequelae of Obese Craniopharyngioma Patients
Pediatric Research:
POST ACCEPTANCE, 7 December 2010
doi: 10.1203/PDR.0b013e3182083b67
In Vivo, Fatty Acid Translocase (CD36) Critically Regulates Skeletal Muscle Fuel Selection, Exercise Performance, and Training-induced Adaptation of Fatty Acid Oxidation
Jay T. McFarlan, Yuko Yoshida, Swati S. Jain, Xioa-Xia Han, Laelie A. Snook, James Lally, Brennan K. Smith, Jan F. C. Glatz, Joost J. F. P. Luiken, Ryan A. Sayer, A. Russell Tupling, Adrian Chabowski, Graham P. Holloway and Arend Bonen
July 6, 2012 The Journal of Biological Chemistry, 287, 23502-23516.
NT-PGC-1α Protein Is Sufficient to Link β3-Adrenergic Receptor Activation to Transcriptional and Physiological Components of Adaptive Thermogenesis*
Ji Suk Chang, Vivian Fernand, Yubin Zhang, Jeho Shin, Hee-Jin Jun, Yagini Joshi and Thomas W. Gettys
March 16, 2012 The Journal of Biological Chemistry, 287, 9100-9111.
Pharmacological Targeting of Glucagon and Glucagon-Like Peptide 1 Receptors Has Different Effects on Energy State and Glucose Homeostasis in Diet-Induced Obese Mice
Wei Gu, David J. Lloyd, Narumol Chinookswong, Renée Komorowski, Glenn Sivits Jr, Melissa Graham, Katherine A. Winters, Hai Yan, Laszlo G. Boros, Richard A. Lindberg and Murielle M. Véniant
JPET July 2011 vol. 338 no. 1 70-81
The Hyperphagic Effect of Ghrelin Is Inhibited in Mice by a Diet High in Fat
James V. Gardiner, Daniel Campbell, Michael Patterson, Aysha Kent, Mohammed A. Ghatei, Stephen R. Bloom, Gavin A. Bewick
Gastroenterology Volume 138, Issue 7 , Pages 2468-2476.e1, June 2010
Peptide Designed to Elicit Apoptosis in Adipose Tissue Endothelium Reduces Food Intake and Body Weight
Dong-Hoon Kim, Stephen C. Woods and Randy J. Seeley
Diabetes April 2010 vol. 59 no. 4 907-915
Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis
Christian Stockmannb, Yann Kerdiles, Marc Nomaksteinsky, Alexander Weidemann, Norihiko Takeda, Andrew Doedens, Antonio X. Torres-Collado, Luisa Iruela-Arispe, Victor Nizet, and Randall S. Johnson
PNAS March 2, 2010 vol. 107 no. 9 4329-4334
Enhanced Energy Expenditure, Glucose Utilization, and Insulin Sensitivity in VAMP8 Null Mice
Haihong Zong, Cheng-Chun Wang, Bhavapriya Vaitheesvaran, Irwin J. Kurland, Wanjin Hong and Jeffrey E. Pessin
Diabetes January 2011 vol. 60 no. 1 30-38
Leptin-Independent Programming of Adult Body Weight and Adiposity in Mice
Elizabeth C. Cottrell, Malgorzata S. Martin-Gronert, Denise S. Fernandez-Twinn, Jian'an Luan, Lindsey M. Berends and Susan E. Ozanne
Endocrinology Vol. 152, No. 2 476-482
Aging-Associated Changes in Physical Performance and Energy Metabolism in the Senescence-Accelerated Mouse
Satoshi Haramizu, Noriyasu Ota, Tadashi Hase and Takatoshi Murase
J Gerontol A Biol Sci Med Sci (2011) 66A (6): 646-655.
doi: 10.1093/gerona/glr037
Loss of polyubiquitin gene Ubb leads to metabolic and sleep abnormalities in mice
K.-Y. Ryu, N. Fujiki, M. Kazantzis, J. C. Garza, D. M. Bouley, A. Stahl, X.-Y. Lu, S. Nishino, R. R. Kopito
Neuropathology and Applied Neurobiology
Volume 36, Issue 4, pages 285-299, June 2010
Leptin potentiates the anti-obesity effects of rimonabant
Carine M. Boustany-Kari, V. Margaret Jackson, Colleen P. Gibbons and Andrew G. Swick
European Journal of Pharmacology
Volume 658, Issues 2-3, 11 May 2011, Pages 270-276
Shp2 Controls Female Body Weight and Energy Balance by Integrating Leptin and Estrogen Signals
Zhao He, Sharon S. Zhang, Qingyuan Meng, Shuangwei Li, Helen H. Zhu, Marie-Astrid Raquil, Nazilla Alderson, Hai Zhang, Jiarui Wu, Liangyou Rui, Dongsheng Cai and Gen-Sheng Feng
Mol. Cell. Biol. May 2012 vol. 32 no. 10 1867-1878
Iron Overload and Diabetes Risk: A Shift From Glucose to Fatty Acid Oxidation and Increased Hepatic Glucose Production in a Mouse Model of Hereditary Hemochromatosis
Jingyu Huang, Deborah Jones, Bai Luo, Michael Sanderson, Jamie Soto, E. Dale Abel, Robert C. Cooksey and Donald A. McClain
Diabetes January 2011 vol. 60 no. 1 80-87
Energy expenditure and bone formation share a common sensitivity to AP-1 transcription in the hypothalamus
Glenn C Rowe, Vincent Vialou, Kazusa Sato, Hiroaki Saito, Min Yin, Thomas A Green, Sutada Lotinun, Marie Kveiborg, William C Horne, Eric J Nestler, Roland Baron
Journal of Bone and Mineral Research
Volume 27, Issue 8, pages 1649-1658, August 2012
Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production
Ruifeng Teng, Oksana Gavrilova, Norio Suzuki, Tatyana Chanturiya, Daniel Schimel, Lynne Hugendubler, Selin Mammen, Dena R. Yver, Samuel W. Cushman, Elisabetta Mueller, Masayuki Yamamoto, Lewis L. Hsu & Constance Tom Noguchi
Nature Communications 2, Article number: 520 doi:10.1038/ncomms1526
Methylotrophic methanogenic Thermoplasmata implicated in reduced methane emissions from bovine rumen
Morten Poulsen, Clarissa Schwab, Bent Borg Jensen, Ricarda M. Engberg, Anja Spang, Nuria Canibe, Ole Højberg, Gabriel Milinovich, Lena Fragner, Christa Schleper, Wolfram Weckwerth, Peter Lund, Andreas Schramm & Tim Urich
Nature Communications 4, Article number: 1428 doi:10.1038/ncomms2432
Insulin detemir attenuates food intake, body weight gain and fat mass gain in diet-induced obese Sprague–Dawley rats OPEN
J M Rojas, R L Printz & K D Niswender
Nutrition and Diabetes 1, e10 doi:10.1038/nutd.2011.6
Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis
V L Albaugh, J G Judson, P She, C H Lang, K P Maresca, + et al.
Molecular Psychiatry 16, 569-581 doi:10.1038/mp.2010.33
Davalintide (AC2307), a novel amylin-mimetic peptide: enhanced pharmacological properties over native amylin to reduce food intake and body weight
C M Mack, C J Soares, J K Wilson, J R Athanacio, V F Turek, + et al.
International Journal of Obesity 34, 385-395 doi:10.1038/ijo.2009.238
Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high-fat diet-induced diabetes
Shingo Takada, Shintaro Kinugawa, Shouji Matsushima, Daisuke Takemoto, Takaaki Furihata, Wataru Mizushima, Arata Fukushima, Takashi Yokota, Yoshiko Ono, Hiroshi Shibata, Koichi Okita, Hiroyuki Tsutsui
Experimental Physiology, 24 August 2015
The Sphingosine-1-Phosphate Analog FTY720 Reduces Muscle Ceramide Content and Improves Glucose Tolerance in High Fat-Fed Male Mice
Clinton R. Bruce, Steve Risis, Joanne R. Babb, Christine Yang, Robert S. Lee-Young, Darren C. Henstridge and Mark A. Febbraio
Endocrinology January 1, 2013 vol. 154 no. 1 65-76
Adaptation of the rat cardiac proteome in response to intensity-controlled endurance exercise
Jatin G. Burniston Dr.
PROTEOMICS
Volume 9, Issue 1, pages 106-115, No. 1 January 2009
Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis
Alison S. Reed, Elizabeth K. Unger, Louise E. Olofsson, Merisa L. Piper, Martin G. Myers Jr and Allison W. Xu
Diabetes April 2010 vol. 59 no. 4 894-906
Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation
Mirjam Langeveld, Sjoerd A.A. van den Berg, 1, Nora Bijl, Silvia Bijland, Cindy P. van Roomen, Judith H. Houben-Weerts, Roelof Ottenhoff, Sander M. Houten, Ko Willems van Dijk, Johannes A. Romijn, Albert K. Groen, Johannes M. Aerts, Peter J. Voshol
Metabolism
Volume 61, Issue 1, January 2012, Pages 99-107
Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity
Sebastian Beck Jorgensen, Hayley M. O’Neill, Lykke Sylow, Jane Honeyman, Kimberly A. Hewitt, Rengasamy Palanivel, Morgan D. Fullerton, Lisa Öberg, Anudharan Balendran, Sandra Galic, Chris van der Poel, Ian A. Trounce, Gordon S. Lynch, Jonathan D. Schertzer and Gregory R. Steinberg
Diabetes September 6, 2012
Dietary Medium-Chain Triglycerides Attenuate Hepatic Lipid Deposition in Growing Rats with Protein Malnutrition
Masashi KUWAHATA, Hiroyo KUBOTA, Saki AMANO, Meiko YOKOYAMA, Yasuhiro SHIMAMURA, Shunsuke ITO, Aki OGAWA, Yukiko KOBAYASHI, Ken-ichi MIYAMOTO, Yasuhiro KIDO
Journal of Nutritional Science and Vitaminology
Vol. 57 (2011) No. 2 P 138-143
META060 protects against diet-induced obesity and insulin resistance in a high-fat–diet fed mouse
Irene O.C.M. Vroegrijk, M.Sc., Janna A. van Diepen, M.Sc., Sjoerd A.A. van den Berg, Ph.D., Johannes A. Romijn, M.D., Ph.D., Louis M. Havekes, Ph.D., Ko Willems van Dijk, Ph.D., Gary Darland, Ph.D., Veera Konda, Ph.D., Matthew L. Tripp, Ph.D., Jeffrey S. Bland, Ph.D., Peter J. Vosho, Ph.D.
Nutrition
Volume 29, Issue 1, January 2013, Pages 276-283
Constitutive Activation of IKKβ in Adipose Tissue Prevents Diet-Induced Obesity in Mice
Ping Jiao, Bin Feng, Jie Ma, Yaohui Nie, Erin Paul, Yujie Li and Haiyan Xu
Endocrinology January 1, 2012 vol. 153 no. 1 154-165
G-protein-coupled receptor GPR21 knockout mice display improved glucose tolerance and increased insulin response
Jonitha Gardner, Sue Wu, Lei Ling, Jean Danao, Yang Li, Wen-Chen Yeh, Hui Tian, Hélène Baribault
Biochemical and Biophysical Research Communications
Volume 418, Issue 1, 3 February 2012, Pages 1-5
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
Andrew C. Adams, Chaofeng Yang, Tamer Coskun, Christine C. Cheng, Ruth E. Gimeno, Yongde Luo, Alexei Kharitonenkov
Molecular Metabolism
Available online 27 August 2012
Calorie restriction in mice overexpressing UCP3: Evidence that prior mitochondrial uncoupling alters response
Carmen Estey, Erin L. Seifert, Céline Aguer, Cynthia Moffat, Mary-Ellen Harper
Experimental Gerontology
Volume 47, Issue 5, May 2012, Pages 361-371
GRK5 deficiency decreases diet-induced obesity and adipogenesis
Feifei Wang, Li Wang, Minjie Shen, Lan Ma
Biochemical and Biophysical Research Communications
Volume 421, Issue 2, 4 May 2012, Pages 312-317
Skeletal Muscle AMP-activated Protein Kinase Is Essential for the Metabolic Response to Exercise in Vivo
Robert S. Lee-Young, Susan R. Griffee, Sara E. Lynes, Deanna P. Bracy, Julio E. Ayala, Owen P. McGuinness and David H. Wasserman
September 4, 2009 The Journal of Biological Chemistry, 284, 23925-23934.
Ski overexpression in skeletal muscle modulates genetic programs that control susceptibility to diet-induced obesity and insulin signaling
Diaz, Marianne, Martel, Nick, Fitzsimmons, Rebecca L., Eriksson, Natalie A., Cowin, Gary J., Thomas, Gethin P., Le Cao, Kim-Anh, Muscat, George E. O. and Leong, Gary M
Obesity (Silver Spring). 2012 Nov;20(11):2157-67
Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: Implications for liver regeneration
Manuel Alejandro Fernández-Rojo, Christina Restall, Charles Ferguson, Nick Martel, Sally Martin, Marta Bosch, Adam Kassan, Gary M. Leong, Sheree D. Martin, Sean L. McGee, George E.O. Muscat, Robin L. Anderson, Carlos Enrich, Albert Pol, Robert G. Parton
Hepatology
Volume 55, Issue 5, pages 1574-1584, May 2012
Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease
Pengxiang She, Zhiyou Zhang, Deanna Marchionini, William C. Diaz, Thomas J. Jetton, Scot R. Kimball, Thomas C. Vary, Charles H. Lang, and Christopher J. Lynch
AJP - Endo July 1, 2011 vol. 301 no. 1 E49-E61
The Thermogenic Effect of Leptin Is Dependent on a Distinct Population of Prolactin-Releasing Peptide Neurons in the Dorsomedial Hypothalamus
Garron T. Dodd, Amy A. Worth, Nicolas Nunn, Aaron K. Korpal, David A. Bechtold, Margaret B. Allison, Martin G. Myers Jr., Michael A. Statnick, Simon M. Luckman
Cell Metabolism, August 2014, DOI: 10.1016/j.cmet.2014.07.022
Synergistic metabolic benefits of an exenatide analog and cholecystokinin (CCK) in diet-induced obese and leptin-deficient rodents.
James L. Trevaskis, Chengzao Sun, Jennifer Athanacio, Lawrence D'Souza, Manoj Samant, Krystyna Tatarkiewicz, Peter S. Griffin, Carrie Wittmer, Yan Wang, Chi-Hse Teng, Bruce Forood, David G. Parkes andJonathan D. Roth
Diabetes, Obesity and Metabolism, 2014, DOI: 10.1111/dom.12390
Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice
Hanlin Tao, Yong Zhang, Xiangang Zeng, Gerald I Shulman & Shengkan Jin
Nature Medicine (5 October 2014), doi:10.1038/nm.3699
Prebiotic fibres dose-dependently increase satiety hormones and alter Bacteroidetes and Firmicutes in lean and obese JCR:LA-cp rats
Jill A. Parnell and Raylene A. Reimer
British Journal of Nutrition / Volume 107 / Issue 04 / February 2012, pp 601-613
Epigenetic dysregulation of the dopamine system in diet-induced obesity
Zivjena Vucetic, Jesse Lea Carlin, Kathy Totoki, Teresa M. Reyes
Journal of Neurochemistry
Volume 120, Issue 6, pages 891-898, March 2012
Direct fed microbial supplementation repartitions host energy to the immune system
R. Qiu, J. Croom, R. A. Ali, A. L. Ballou, C. D. Smith, C. M. Ashwell, H. M. Hassan, C.-C. Chiang and M. D. Koci
J ANIM SCI August 2012 vol. 90 no. 8 2639-2651
Y1 and Y5 Receptors Are Both Required for the Regulation of Food Intake and Energy Homeostasis in Mice
Amy D. Nguyen, Natalie F. Mitchell, Shu Lin, Laurence Macia, Ernie Yulyaningsih,
Paul A. Baldock, Ronaldo F. Enriquez, Lei Zhang, Yan-Chuan Shi, Serge Zolotukhin, Herbert Herzog, Amanda Sainsbury
PLoS ONE 7(6): e40191. doi:10.1371/journal.pone.0040191
Neuropeptide Y and Agouti-Related Peptide Mediate Complementary Functions of Hyperphagia and Reduced Energy Expenditure in Leptin Receptor Deficiency
Na Luo, Genevieve Marcelin, Shun Mei Liu, Gary Schwartz and Streamson Chua Jr
Endocrinology March 1, 2011 vol. 152 no. 3 883-889
8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction
Harini Sampath, Vladimir Vartanian, M. Rick Rollins, Kunihiko Sakumi, Yusaku Nakabeppu, R. Stephen Lloyd
PLoS ONE 7(12): e51697. doi:10.1371/journal.pone.0051697
Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3β and mitochondrial function
Yingmei Zhang, Sara A Babcock, Nan Hu, Jacalyn R Maris, Haichang Wang and Jun Ren
BMC Medicine 2012, 10:40 doi:10.1186/1741-7015-10-40
Anti-Obesity Effects of Granulocyte-Colony Stimulating Factor in Otsuka-Long-Evans-Tokushima Fatty Rats
Yonggu Lee, Yi-Sun Song, Cheng-Hu Fang, Byung-Im So, Jun-Young Park, Hyun-Woo Joo, In-Hwa Park, Guang-Yin Shen, Jeong-Hun Shin, Hyuck Kim, You-Heon Ahn, Kyung-Soo Kim
PLOS ONE, August 21, 2014, DOI: 10.1371/journal.pone.0105603
Time-of-day-dependent dietary fat consumption influences multiple cardiometabolic syndrome parameters in mice
M S Bray, J-Y Tsai, C Villegas-Montoya, B B Boland, Z Blasier, O Egbejimi, M Kueht and M E Young
International Journal of Obesity 34, 1589-1598 (November 2010)
Dietary Whey Protein Decreases Food Intake and Body Fat in Rats
June Zhou, Michael J. Keenan, Jack N. Losso, Anne M. Raggio, Li Shen, Kathleen L. McCutcheon, Richard T. Tulley, Marc R. Blackman, Roy J. Martin
Obesity
Volume 19, Issue 8, pages 1568-1573, August 2011
Insulin Causes Hyperthermia by Direct Inhibition of Warm-Sensitive Neurons
Manuel Sanchez-Alavez, Iustin V. Tabarean, Olivia Osborn, Kayo Mitsukawa, Jean Schaefer, Jeffrey Dubins, Kristina H. Holmberg, Izabella Klein, Joe Klaus, Luis F. Gomez, Hartmuth Kolb, James Secrest, Jeanine Jochems, Kevin Myashiro, Peter Buckley, John R. Hadcock, James Eberwine, Bruno Conti and Tamas Bartfai
Diabetes January 2010 vol. 59 no. 1 43-50
IL-15 Receptor Deletion Results in Circadian Changes of Locomotor and Metabolic Activity
Yi He, Xiaojun Wu, Reas S. Khan, Abba J. Kastin, Germaine G. Cornelissen-Guillaume, Hung Hsuchou, Barry Robert, Franz Halberg and Weihong Pan
JOURNAL OF MOLECULAR NEUROSCIENCE
Volume 41, Number 2, 315-321
Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway
Kristy L. Townsend, Ryo Suzuki, Tian Lian Huang, Enxuan Jing, Tim J. Schulz, Kevin Lee, Cullen M. Taniguchi, Daniel O. Espinoza, Lindsay E. McDougall, Hongbin Zhang, Tong-Chuan He, Efi Kokkotou and Yu-Hua Tseng
May 2012
The FASEB Journal
vol. 26 no. 5 2187-2196
Enhanced Amylin-Mediated Body Weight Loss in Estradiol-Deficient Diet-Induced Obese Rats
James L. Trevaskis, Victoria F. Turek, Carrie Wittmer, Peter S. Griffin, Julie K. Wilson, James M. Reynolds, Yu Zhao, Christine M. Mack, David G. Parkes and Jonathan D. Roth
Endocrinology Vol. 151, No. 12 5657-5668
Identification of Body Fat Mass as a Major Determinant of Metabolic Rate in Mice
Karl J. Kaiyala, Gregory J. Morton, Brian G. Leroux, Kayoko Ogimoto, Brent Wisse and Michael W. Schwartz
Diabetes July 2010 vol. 59 no. 7 1657-1666
Glutaredoxin-2 is required to control proton leak through uncoupling protein-3
Ryan J. Mailloux, Jian Ying Xuan, Brittany Beauchamp, Linda Jui, Marjorie Lou and Mary-Ellen Harper
January 18, 2013, doi: 10.1074/jbc.M112.442905
jbc.M112.442905.
Maternal Obesity during Gestation Impairs Fatty Acid Oxidation and Mitochondrial SIRT3 Expression in Rat Offspring at Weaning
Sarah J. Borengasser, Franchesca Lau, Ping Kang, Michael L. Blackburn, Martin J. J. Ronis, Thomas M. Badger, Kartik Shankar
PLoS ONE 6(8): e24068. doi:10.1371/journal.pone.0024068
Low birth weight is associated with adiposity, impaired skeletal muscle energetics and weight loss resistance in mice
B Beauchamp, S Ghosh, M W Dysart, G N Kanaan, A Chu, A Blais, K Rajamanickam, E C Tsai, M-E Patti and M-E Harper
International Journal of Obesity advance online publication 5 August 2014; doi: 10.1038/ijo.2014.120
Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9
Brian J DeBosch, Oliver Kluth, Hideji Fujiwara, Annette Schürmann & Kelle Moley
Nature Communications 5, Article number: 4642 doi:10.1038/ncomms5642
Fasting hypometabolism and refeeding hyperphagia in rats: Effects of capsaicin desensitization of the abdominal vagus
Andras Garami, Marta Balasko, Miklos Szekely, Margit Solymar, Erika Petervari
European Journal of Pharmacology 644 (2010) 61-66
Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice
Ryan S. Streeper, Carrie A. Grueter, Nathan Salomonis, Sylvaine Cases, Malin C. Levin, Suneil K. Koliwad, Ping Zhou, Matthew D. Hirschey, Eric Verdin, and Robert V. Farese, Jr.
Aging (Albany NY). 2012 January; 4(1): 13-27.
Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets
Laurence Macia, Vicky Wang-Wei Tsai, Amy D. Nguyen, Heiko Johnen, Tamara Kuffner, Yan-Chuan Shi, Shu Lin, Herbert Herzog, David A. Brown, Samuel N. Breit, Amanda Sainsbury
2012 PLoS ONE 7(4): e34868. doi:10.1371/journal.pone.0034868
Foxo1 regulates Dbh expression and the activity of the sympathetic nervous system in vivo
Daisuke Kajimura, Riccardo Paone, J. John Mann, Gerard Karsenty
Molecular Metabolism, Available online 29 July 2014
PACAP is essential for the Adaptive Thermogenic Response of Brown Adipose Tissue to Cold Exposure
Abdoulaye Diane, Nikolina Nikolic, Alexander P Rudecki, Shannon M King, Drew J Bowie and Sarah L Gray
J Endocrinol July 23, 2014 JOE-14-0316
Combination of meal and exercise timing with a high-fat diet influences energy expenditure and obesity in mice
Hiroyuki Sasaki, Teiji Ohtsu, Yuko Ikeda, Miku Tsubosaka, and Shigenobu Shibata
Chronobiology International, Posted online on July 9, 2014. (doi:10.3109/07420528.2014.935785)
Adipose Triglyceride Lipase-Null Mice Are Resistant to High-Fat Diet–Induced Insulin Resistance Despite Reduced Energy Expenditure and Ectopic Lipid Accumulation
Andrew J. Hoy, Clinton R. Bruce, Sarah M. Turpin, Alexander J. Morris, Mark A. Febbraio and Matthew J. Watt
Endocrinology Vol. 152, No. 1 48-58
Intracerebroventricular injection of adiponectin regulates locomotor activity in rats
Yumiko Miyatake, Tetsuya Shiuchi, Tomoyo Ueta, Yasuko Taniguchi, Akari Futami, Fukiko Sato, Tadahiro Kitamura, Rie Tsutsumi, Nagakatsu Harada, Yutaka Nakaya, and Hiroshi Sakaue
The Journal of Medical Investigation, Vol. 62, 2015
Effect of photoperiod on the feline adipose transcriptome as assessed by RNA sequencing
Akihiro Mori, Kelly L Kappen, Anna C Dilger and Kelly S Swanson
BMC Veterinary Research 2014, 10:146
Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle
Rie Tsutsumi, Tomomi Yoshida, Yoshitaka Nii, Naoki Okahisa, Shinya Iwata, Masao Tsukayama, Rei Hashimoto, Yasuko Taniguchi, Hiroshi Sakaue, Toshio Hosaka, Emi Shuto, Tohru Sakai
Nutrition and Metabolism, 2014
ENPP2 contributes to adipose tissue expansion in diet-induced obesity
Satoshi Nishimura, Mika Nagasaki, Shinichi Okudaira, Junken Aoki, Tsukasa Ohmori, Ryunosuke Ohkawa, Kazuhiro Nakamura, Koji Igarashi, Hiroshi Yamashita, Koji Eto, Kansei Uno, Naoto Hayashi, Takashi Kadowaki, Issei Komuro, Yutaka Yatomi and Ryozo Nagai
Diabetes June 26, 2014
Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency
Caterina Garone, Beatriz Garcia?Diaz, Valentina Emmanuele, Luis C Lopez, Saba Tadesse, Hasan O Akman, Kurenai Tanji, Catarina M Quinzii, Michio Hirano
EMBO Molecular Medicine, Volume 6, Issue 7
01 July 2014 | pp 851 - 992
Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy
Marcelo A. Mori, Thomas Thomou, Jeremie Boucher, Kevin Y. Lee, Susanna Lallukka, Jason K. Kim, Martin Torriani, Hannele Yki-Järvinen, Steven K. Grinspoon, Aaron M. Cypess and C. Ronald Kahn
J Clin Invest. doi:10.1172/JCI73468. July 1, 2014
Kaempferia parviflora extract increases energy consumption through activation of BAT in mice
Susumu Yoshino, Minji Kim, Riyo Awa, Hiroshige Kuwahara, Yuriko Kano3 andTeruo Kawada
Food Science & Nutrition, published online: 15 JUL 2014 DOI: 10.1002/fsn3.144
Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity
Pengpeng Bi, Tizhong Shan, Weiyi Liu, Feng Yue, Xin Yang, Xin-Rong Liang, Jinghua Wang, Jie Li, Nadia Carlesso, Xiaoqi Liu & Shihuan Kuang
Nature Medicine (2014) doi:10.1038/nm.3615
Pre-tumor exercise decreases breast cancer in old mice in a distance-dependent manner
Jorming Goh, Emma Endicott, Warren C Ladiges
Am J Cancer Res 2014;4(4):378-384
Transgenic Mice Overexpressing Amyloid Precursor Protein Exhibit Early Metabolic Deficits and a Pathologically Low Leptin State Associated with Hypothalamic Dysfunction in Arcuate Neuropeptide Y Neurons
Makoto Ishii, Gang Wang, Gianfranco Racchumi, Jonathan P. Dyke, and Costantino Iadecola
The Journal of Neuroscience, 2 July 2014, 34(27): 9096-9106; doi: 10.1523/JNEUROSCI.0872-14.2014
Characterization of the Thermoregulatory Response to Pituitary Adenylate Cyclase-Activating Polypeptide in Rodents
Eszter Banki, Eszter Pakai, Balazs Gaszner, Csaba Zsiboras, Andras Czett, Paras Rahul Parkash Bhuddi, Hitoshi Hashimoto, Gabor Toth, Andrea Tamas, Dora Reglodi, Andras Garami
Journal of Molecular Neuroscience July 2014
Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure
ChuanFeng Wang, Eric Bomberga, Charles J. Billington, Allen S. Levine and Catherine M. Kotz
Brain Research Volume 1336, 8 June 2010, Pages 66-77
PTPRT Regulates High-Fat Diet-Induced Obesity and Insulin Resistance
Xiujing Feng, Anthony Scott, Yong Wang, Lan Wang, Yiqing Zhao, Stephanie Doerner, Masanobu Satake, Colleen M. Croniger, Zhenghe Wang
PLOS ONE, June 20, 2014 DOI: 10.1371/journal.pone.0100783
Breathing and temperature control disrupted by morphine and stabilized by clonidine in neonatal rats
Kalpashri Kesavan, Tarrah Ezell, Alexis Bierman, Ana Rita Nunes, Frances J. Northington, Clarke G. Tankersley, Estelle B. Gauda
Respiratory Physiology & Neurobiology, Available online 5 July 2014
Augmented expression and secretion of adipose-derived pigment epithelium-derived factor does not alter local angiogenesis or contribute to the development of systemic metabolic derangements
Thomas V. Lakeland, Melissa L. Borg, Maria Matzaris, Amany Abdelkader, Roger G. Evans, Matthew J. Watt
American Journal of Physiology - Endocrinology and Metabolism, June 2014, Vol. 306 no. E1367-E1377 DOI: 10.1152/ajpendo.00046.2014
Effects of Light Color on Energy Expenditure and Behavior in Broiler Chickens
Nara Kim, Sang-rak Lee, and Sang-Jin Lee
Asian Australas. J. Anim. Sci.
Vol. 27, No. 7 : 1044-1049 July 2014
Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes, but not with insulin resistance
Paul J. Meakin, Sudhir Chowdhry, Ritu S. Sharma, Fiona B. Ashford, Shaun V. Walsh, Rory J. McCrimmon, Albena T. Dinkova-Kostova, John F. Dillon, John D. Hayes and Michael L.J. Ashford
Mol. Cell. Biol., 23 June 2014, doi:10.1128/MCB.00677-14
Running Exercise and Angiotensin II Type I Receptor Blocker Telmisartan Are Equally Effective in Preventing Angiotensin II-Mediated Vulnerable Atherosclerotic Lesions
Maxime Pellegrin, Justyna Szostak, Karima Bouzourène, Jean-François Aubert, Alain Berthelot, Jürg Nussberger, Pascal Laurant, Lucia Mazzolai
Journal of Cardiovacular Pharmacology and Theraputics, 30 May 2016
Macrophage Depletion Disrupts Immune Balance and Energy Homeostasis
Bonggi Lee, Liping Qiao, Brice Kinney, Gen-Sheng Feng, Jianhua Shao
PLOS ONE, June 09, 2014 DOI: 10.1371/journal.pone.0099575
Mice Lacking the Neuropeptide alpha-Calcitonin Gene-Related Peptide Are Protected Against Diet-Induced Obesity
Christopher S. Walker, Xiaoling Li, Lynda Whiting, Sarah Glyn-Jones, Shaoping Zhang, Anthony J. Hickey, Mary A. Sewell, Katya Ruggiero, Anthony R. J. Phillips, Edward W. Kraegen, Debbie L. Hay, Garth J. S. Cooper and Kerry M. Loomes
Endocrinology Vol. 151, No. 9 4257-4269
Enhanced Hypothalamic Leptin Signaling in Mice Lacking Dopamine D2 Receptors
Kyu Seok Kim, Ye Ran Yoon, Hyo Jin Lee, Sehyoun Yoon, Sa-Yong Kim, Seung Woo Shin, Juan Ji An, Min-Seon Kim, Se-Young Choi, Woong Sun and Ja-Hyun Baik
March 19, 2010 The Journal of Biological Chemistry, 285, 8905-8917.
Ischemic neuroprotection by TRPV1 receptor-induced hypothermia
Mirko Muzzi, Roberta Felici, Leonardo Cavone, Elisabetta Gerace, Alberto Minassi, Giovanni Appendino, Flavio Moroni and Alberto Chiarugi
Journal of Cerebral Blood Flow & Metabolism (2012) 32, 978-982; doi:10.1038/jcbfm.2012.36
Adipocyte-specific deletion of mTOR inhibits adipose tissue development and causes insulin resistance in mice
Tizhong Shan, Pengpeng Zhang, Qinyang Jiang, Yan Xiong, Yizhen Wang, Shihuan Kuang
Diabetologia, Vol. 59, Issue 9, Pages 1995-2004, September 2016
Exaggerated effects of particulate matter air pollution in genetic type II diabetes
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Cuiqing Liu, Yuntao Bai, Xiaohua Xu, Lixian Sun, Aixia Wang, Tse-Yao Wang, Santosh K Maurya, Muthu Periasamy, Masako Morishita, Jack Harkema, Zhekang Ying, Qinghua Sun, Sanjay Rajagopalan
Particle and Fibre Toxicology 2014, 11:27 doi:10.1186/1743-8977-11-27
Activities of Nonlysosomal Proteolytic Systems in Skeletal and Cardiac Muscle During Burn-Induced Hypermetabolism.
Wong, Yee M. MD; La Porte, Heather M. BS; Szilagyi, Andrea BS; Bach, Harold H. IV MD; Ke-He, Li MD; Kennedy, Richard H. PhD; Gamelli, Richard L. MD; Shankar, Ravi PhD; Majetschak, Matthias MD, PhD
Journal of Burn Care & Research: POST COPYEDIT, 29 May 2014 doi: 10.1097/BCR.0000000000000060
Fasting Energy Homeostasis in Mice with Adipose Deficiency of Desnutrin/Adipose Triglyceride Lipase
Jiang Wei Wu, Shu Pei Wang, Stéphanie Casavant, Alain Moreau, Gong She Yang and Grant A. Mitchell
Endocrinology May 1, 2012 vol. 153 no. 5 2198-2207
AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin
Izabella Klein, Manuel Sanchez-Alavez, Iustin Tabarean, Jean Schaefer, Kristina H. Holmberg, Joe Klaus, Fengcheng Xia, Maria Cecilia Garibaldi Marcondes, Jeffrey S. Dubins, Brad Morrison, Viktor Zhukov, Alejandro Sanchez-Gonzalez, Kayo Mitsukawa, John R. Hadcock, Tamas Bartfai, Bruno Conti
Brain Research
Volume 1423, 14 November 2011, Pages 1-9
Intermittent Cold Exposure Enhances Fat Accumulation in Mice
Hyung sun Yoo, Liping Qiao, Chris Bosco, Lok-Hei Leong, Nikki Lytle, Gen-Sheng Feng, Nai-Wen Chi, Jianhua Shao
PLOS ONE, Published: May 02, 2014DOI: 10.1371/journal.pone.0096432
Targeting Protein Synthesis in a Myc/mTOR-Driven Model of Anorexia-Cachexia Syndrome Delays Its Onset and Prolongs Survival
Francis Robert, John R. Mills, Aouod Agenor, Dantong Wang, Sergio DiMarco, Regina Cencic, Michel L. Tremblay, Imed Eddine Gallouzi, Siegfried Hekimi, Simon S. Wing, and Jerry Pelletier
Cancer Res February 1, 2012 72; 747
GQ-16, a Novel Peroxisome Proliferator-activated Receptor γ (PPARγ) Ligand, Promotes Insulin Sensitization without Weight Gain
Angélica A. Amato, Senapathy Rajagopalan, Jean Z. Lin, Bruno M. Carvalho, Ana C. M. Figueira, Jenny Lu, Stephen D. Ayers, Melina Mottin, Rodrigo L. Silveira, Paulo C. T. Souza, Rosa H. V. Mourao, Mário J. A. Saad, Marie Togashi, Luiz A. Simeoni, Dulcinéia S. P. Abdalla, Munir S. Skaf, Igor Polikparpov, Maria C. A. Lima, Suely L. Galdino, Richard G. Brennan, John D. Baxter, Ivan R. Pitta, Paul Webb, Kevin J. Phillips and Francisco A. R. Neves
August 10, 2012 The Journal of Biological Chemistry, 287, 28169-28179.
Prokineticin 2 is involved in the thermoregulation and energy expenditure
Wenbai Zhou, Jia-Da Li, Wang-Ping Hu, Michelle Y. Cheng, Qun-Yong Zhou
Regulatory Peptides
Volume 179, Issues 1-3, 10 November 2012, Pages 84-90
Astrocytic leptin receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity
Bhavaani Jayaram, Weihong Pan, Yuping Wang, Hung Hsuchou, Aurelien Mace, Germaine G. Cornelissen-Guillaume, Pramod K. Mishra, Robert A. Koza, and Abba J. Kastin
Journal of Applied Physiology January 17, 2013 jap.01499.2012
Central Glucagon-Like Peptide 1 Receptor (Glp1r)-Induced Anorexia Requires Glucose Metabolism-Mediated Suppression of AMPK and is Impaired by Central Fructose.
Melissa A. Burmeister, Jennifer E. Ayala, Daniel J. Drucker, and Julio E. Ayala
AJP - Endo January 22, 2013 ajpendo.00446.2012
Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of Amyotrophic Lateral Sclerosis
Maria A. Lim, Kendra K. Bence, Ishani Sandesara, Pénélope Andreux, Johan Auwerx, Jeff Ishibashi, Patrick Seale and Robert G. Kalb
Hum. Mol. Genet. (2014) doi: 10.1093/hmg/ddu214 First published online: May 15, 2014
Central Sirt1 regulates body weight and energy expenditure along with the POMC-derived peptide ?-MSH and the processing enzyme CPE production in diet-induced Obesity male rats
Nicole E. Cyr, Jennifer S. Steger, Anika M. Toorie, Jonathan Z. Yang, Ronald Stuart, and Eduardo A. Nillni
Endocrinology: Published Online: April 28, 2014
Effects of thiol antioxidant β-mercaptoethanol on diet-induced obese mice
Siu Wong, James L. Kirkland, Heidi A. Schwanz, Amber L. Simmons, James A. Hamilton, Barbara E. Corkey, Wen Guo
Life Sciences Available online 4 May 2014
IKK epsilon is key to induction of insulin resistance in the hypothalamus and its inhibition reverses obesity
LaÃs Weissmann, Paula G.F. Quaresma, Andressa C. Santos, Alexandre H. B. de Matos, VÃnicius D’Ãvila Bittencourt Pascoal, Tamires M. Zanotto, Gisele Castro, Dioze Guadgnini, Joelcimar Martins da Silva, Licio A. Velloso, Jackson C. Bittencourt, Iscia Lopes-Cendes, Mario J.A. Saad and Patricia O. Prada
Diabetes May 8, 2014
Pank1 deletion in leptin-deficient mice reduces hyperglycaemia and hyperinsulinaemia and modifies global metabolism without affecting insulin resistance
Roberta Leonardi, Charles O. Rock, Suzanne Jackowski
Diabetologia April 2014
Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice
Andréa M. Caricilli, Paty K. Picardi, Lélia L. de Abreu, Mirian Ueno, PatrÃcia O. Prada, Eduardo R. Ropelle, Sandro Massao Hirabara, Ângela Castoldi, Pedro Vieira, Niels O. S. Camara, Rui Curi, José B. Carvalheira, Mário J. A. Saad
Research Article | published 06 Dec 2011 | PLOS Biology
10.1371/journal.pbio.1001212
ENU-induced Mutation in the DNA-binding Domain of KLF3 Reveals Important Roles for KLF3 in Cardiovascular Development and Function in Mice
Lois Kelsey, Ann M. Flenniken, Dawei Qu, Alister P. W. Funnell, Richard Pearson, Yu-Qing Zhou, Irina Voronina, Zorana Berberovic, Geoffrey Wood, Susan Newbigging, Edward S. Weiss, Michael Wong, Ivan Quach, S. Y. Sandy Yeh, Ashish R. Deshwar, Ian C. Scott, Colin McKerlie, Mark Henkelman, Peter Backx, Jeremy Simpson, Lucy Osborne, Janet Rossant, Merlin Crossley, Benoit Bruneau, S. Lee Adamson
Research Article | published 11 Jul 2013 | PLOS Genetics
10.1371/journal.pgen.1003612
Postnatal deficiency of essential fatty acids in mice results in resistance to diet-induced obesity and low plasma insulin during adulthood
Vilborg Palsdottir, Anna Wickman, Niklas Andersson, Rahil Hezaveh, Bob Olsson, Britt G. Gabrielsson and Birgitta Strandvik
doi:10.1016/j.plefa.2010.11.002
Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure
Watanabe M, Morimoto K, Houten SM, Kaneko-Iwasaki N, Sugizaki T, et al.
PLoS ONE 7(8): e38286. doi:10.1371/journal.pone.0038286
Mutation of SLC35D3 Causes Metabolic Syndrome by Impairing Dopamine Signaling in Striatal D1 Neurons
Zhe Zhang, Chan-Juan Hao, Chang-Gui Li, Dong-Jie Zang, Jing Zhao, Xiao-Nan Li, Ai-Hua Wei, Zong-Bo Wei, Lin Yang, Xin He, Xue-Chu Zhen, Xiang Gao, John R. Speakman, Wei Li
Research Article | published 13 Feb 2014 | PLOS Genetics
10.1371/journal.pgen.1004124
Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse
Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson, Sara Wells, Lydia Teboul, Y. C. Loraine Tung, Debra Rimmington, Fatima Bosch, Veronica Jimenez, Giles S. H. Yeo, Stephen O'Rahilly, Frances M. Ashcroft, Anthony P. Coll, Roger D. Cox
Research Article | published 03 Jan 2013 | PLOS Genetics
10.1371/journal.pgen.1003166
Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System
Qiang Liu, Juan Zhang, Celina Zerbinatti, Yan Zhan, Benedict J. Kolber, Joachim Herz, Louis J. Muglia, Guojun Bu
Research Article | published 11 Jan 2011 | PLOS Biology
10.1371/journal.pbio.1000575
The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice
Xuqi Chen, Rebecca McClusky, Jenny Chen, Simon W. Beaven, Peter Tontonoz, Arthur P. Arnold, Karen Reue
Research Article | published 10 May 2012 | PLOS Genetics
10.1371/journal.pgen.1002709
PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis
Teresa C Leone, John J Lehman, Brian N Finck, Paul J Schaeffer, Adam R Wende, Sihem Boudina, Michael Courtois, David F Wozniak, Nandakumar Sambandam, Carlos Bernal-Mizrachi, Zhouji Chen, John O. Holloszy, Denis M Medeiros, Robert E Schmidt, Jeffrey E Saffitz, E. Dale Abel, Clay F Semenkovich, Daniel P Kelly
Research Article | published 15 Mar 2005 | PLOS Biology
10.1371/journal.pbio.0030101
NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not Cortical Bone Homeostasis in Mice
Yan-Chuan Shi, Shu Lin, Iris P. L. Wong, Paul A. Baldock, Aygul Aljanova, Ronaldo F. Enriquez, Lesley Castillo, Natalie F. Mitchell, Ji-Ming Ye, Lei Zhang, Laurence Macia, Ernie Yulyaningsih, Amy D. Nguyen, Sabrina J. Riepler, Herbert Herzog, Amanda Sainsbury
Research Article | published 29 Jun 2010 | PLOS ONE
10.1371/journal.pone.0011361
Loss of Skeletal Muscle HIF-1α Results in Altered Exercise Endurance
Steven D Mason, Richard A Howlett, Matthew J Kim, I. Mark Olfert, Michael C Hogan, Wayne McNulty, Reed P Hickey, Peter D Wagner, C. Ronald Kahn, Frank J Giordano, Randall S Johnson
Research Article | published 24 Aug 2004 | PLOS Biology
10.1371/journal.pbio.0020288
Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue
Olivia Osborn, Manuel Sanchez-Alavez, Jeffrey S. Dubins, Alejandro Sanchez Gonzalez, Brad Morrison, John R. Hadcock, Tamas Bartfai
Cytokine
Volume 53, Issue 3, March 2011, Pages 311-319
A Mild Impairment of Mitochondrial Electron Transport Has Sex-Specific Effects on Lifespan and Aging in Mice
Bryan G. Hughes, Siegfried Hekimi
Research Article | published 10 Oct 2011 | PLOS ONE
10.1371/journal.pone.0026116
SnoRNA Snord116 (Pwcr1/MBII-85) Deletion Causes Growth Deficiency and Hyperphagia in Mice
Feng Ding, Hong Hua Li, Shengwen Zhang, Nicola M. Solomon, Sally A. Camper, Pinchas Cohen, Uta Francke
Research Article | published 05 Mar 2008 | PLOS ONE
10.1371/journal.pone.0001709
Dystropathology Increases Energy Expenditure and Protein Turnover in the Mdx Mouse Model of Duchenne Muscular Dystrophy
Hannah G. Radley-Crabb, Juan C. Marini, Horacio A. Sosa, Liliana I. Castillo, Miranda D. Grounds, Marta L. Fiorotto
Research Article | published 19 Feb 2014 | PLOS ONE
10.1371/journal.pone.0089277
Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice
Sylvain Lengacher, Touria Nehiri-Sitayeb, Nadia Steiner, Lionel Carneiro, Céline Favrod, Frédéric Preitner, Bernard Thorens, Jean-Christophe Stehle, Laure Dix, François Pralong, Pierre J. Magistretti, Luc Pellerin
Research Article | published 18 Dec 2013 | PLOS ONE
10.1371/journal.pone.0082505
Fibroblast Growth Factor Receptor 1 Signaling in Adult Cardiomyocytes Increases Contractility and Results in a Hypertrophic Cardiomyopathy
Sarah N. Cilvik, Joy I. Wang, Kory J. Lavine, Keita Uchida, Angela Castro, Carolyn M. Gierasch, Carla J. Weinheimer, Stacey L. House, Attila Kovacs, Colin G. Nichols, David M. Ornitz
Research Article | published 11 Dec 2013 | PLOS ONE
10.1371/journal.pone.0082979
Dynamic Regulation of Hepatic Lipid Droplet Properties by Diet
Amanda E. Crunk, Jenifer Monks, Aya Murakami, Matthew Jackman, Paul S. MacLean, Mark Ladinsky, Elise S. Bales, Shannon Cain, David J. Orlicky, James L. McManaman
Research Article | published 11 Jul 2013 | PLOS ONE
10.1371/journal.pone.0067631
Antipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model
Robert K. Naviaux, Zarazuela Zolkipli, Lin Wang, Tomohiro Nakayama, Jane C. Naviaux, Thuy P. Le, Michael A. Schuchbauer, Mihael Rogac, Qingbo Tang, Laura L. Dugan, Susan B. Powell
Research Article | published 13 Mar 2013 | PLOS ONE
10.1371/journal.pone.0057380
Functional Inactivation of the Genome-Wide Association Study Obesity Gene Neuronal Growth Regulator 1 in Mice Causes a Body Mass Phenotype
Angela W. S. Lee, Heidi Hengstler, Kathrin Schwald, Mauricio Berriel-Diaz, Desirée Loreth, Matthias Kirsch, Oliver Kretz, Carola A. Haas, Martin Hrab? de Angelis, Stephan Herzig, Thomas Brümmendorf, Martin Klingenspor, Fritz G. Rathjen, Jan Rozman, George Nicholson, Roger D. Cox, Michael K. E. Schäfer
Research Article | published 23 Jul 2012 | PLOS ONE
10.1371/journal.pone.0041537
Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice
Tatsuya Uebi, Yumi Itoh, Osamu Hatano, Ayako Kumagai, Masato Sanosaka, Tsutomu Sasaki, Satoru Sasagawa, Junko Doi, Keita Tatsumi, Kuniko Mitamura, Eiichi Morii, Katsuyuki Aozasa, Tomohiro Kawamura, Meinoshin Okumura, Jun Nakae, Hajime Takikawa, Toshio Fukusato, Minako Koura, Mayumi Nish, Anders Hamsten, Angela Silveira, Alejandro M. Bertorello, Kazuo Kitagawa, Yasuo Nagaoka, Hidehisa Kawahara, Takeshi Tomonaga, Tetsuji Naka, Shigeo Ikegawa, Noriyuki Tsumaki, Junichiro Matsuda, Hiroshi Takemori
Research Article | published 25 May 2012 | PLOS ONE
10.1371/journal.pone.0037803
Over-Expression of Monoacylglycerol Lipase (MGL) in Small Intestine Alters Endocannabinoid Levels and Whole Body Energy Balance, Resulting in Obesity
Su-Hyoun Chon, John D. Douglass, Yin Xiu Zhou, Nashmia Malik, Joseph L. Dixon, Anita Brinker, Loredana Quadro, Judith Storch
Research Article | published 28 Aug 2012 | PLOS ONE
10.1371/journal.pone.0043962
The A2b Adenosine Receptor Modulates Glucose Homeostasis and Obesity
Hillary Johnston-Cox, Milka Koupenova, Dan Yang, Barbara Corkey, Noyan Gokce, Melissa G. Farb, Nathan LeBrasseur, Katya Ravid
Research Article | published 25 Jul 2012 | PLOS ONE
10.1371/journal.pone.0040584
CD40L Deficiency Attenuates Diet-Induced Adipose Tissue Inflammation by Impairing Immune Cell Accumulation and Production of Pathogenic IgG-Antibodies
Dennis Wolf, Felix Jehle, Alexandra Ortiz Rodriguez, Bianca Dufner, Natalie Hoppe, Christian Colberg, Andrey Lozhkin, Nicole Bassler, Benjamin Rupprecht, Ansgar Wiedemann, Ingo Hilgendorf, Peter Stachon, Florian Willecke, Mark Febbraio, Christoph J. Binder, Christoph Bode, Andreas Zirlik, Karlheinz Peter
Research Article | published 08 Mar 2012 | PLOS ONE
10.1371/journal.pone.0033026
Ablations of Ghrelin and Ghrelin Receptor Exhibit Differential Metabolic Phenotypes and Thermogenic Capacity during Aging
Xiaojun Ma, Ligen Lin, Guijun Qin, Xinping Lu, Marta Fiorotto, Vishwa D. Dixit, Yuxiang Sun
Research Article | published 26 Jan 2011 | PLOS ONE
10.1371/journal.pone.0016391
AMP Deaminase 3 Deficiency Enhanced 5'-AMP Induction of Hypometabolism
Isadora Susan Daniels, William G. O?Brien, Vinay Nath, Zhaoyang Zhao, Cheng Chi Lee
Research Article | published 16 Sep 2013 | PLOS ONE
10.1371/journal.pone.0075418
Development and Verification of a Mouse Model for Roux-en-Y Gastric Bypass Surgery with a Small Gastric Pouch
Zheng Hao, Zhiyun Zhao, Hans-Rudolf Berthoud, Jianping Ye
Research Article | published 11 Jan 2013 | PLOS ONE
10.1371/journal.pone.0052922
Increased Lipolysis and Energy Expenditure in a Mouse Model with Severely Impaired Glucagon Secretion
Phing-How Lou, Natalia Gustavsson, Yue Wang, George K. Radda, Weiping Han
Research Article | published 27 Oct 2011 | PLOS ONE
10.1371/journal.pone.0026671
The Antidepressant Trans-2-Phenylcyclopropylamine Protects Mice from High-Fat-Diet-Induced Obesity
Adi Shemesh, Arian Abdulla, Fajun Yang, Streamson C. Chua, Jeffrey E. Pessin, Haihong Zong
Research Article | published 21 Feb 2014 | PLOS ONE
10.1371/journal.pone.0089199
Sweet Taste Receptor Deficient Mice Have Decreased Adiposity and Increased Bone Mass
Becky R. Simon, Brian S. Learman, Sebastian D. Parlee, Erica L. Scheller, Hiroyuki Mori, William P. Cawthorn, Xiaomin Ning, Venkatesh Krishnan, Yanfei L. Ma, Björn Tyrberg, Ormond A. MacDougald
Research Article | published 22 Jan 2014 | PLOS ONE
10.1371/journal.pone.0086454
The Dipeptidyl Peptidase-4 Inhibitor Des-Fluoro-Sitagliptin Regulates Brown Adipose Tissue Uncoupling Protein Levels in Mice with Diet-Induced Obesity
Takanobu Shimasaki, Takayuki Masaki, Kimihiko Mitsutomi, Daisuke Ueno, Koro Gotoh, Seiichi Chiba, Tetsuya Kakuma, Hironobu Yoshimatsu
Research Article | published 16 May 2013 | PLOS ONE
10.1371/journal.pone.0063626
TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator
Vicky Wang-Wei Tsai, Laurence Macia, Heiko Johnen, Tamara Kuffner, Rakesh Manadhar, Sebastian Beck Jørgensen, Ka Ki Michelle Lee-Ng, Hong Ping Zhang, Liyun Wu, Christopher Peter Marquis, Lele Jiang, Yasmin Husaini, Shu Lin, Herbert Herzog, David A. Brown, Amanda Sainsbury, Samuel N. Breit
Research Article | published 28 Feb 2013 | PLOS ONE
10.1371/journal.pone.0055174
AMPK Regulates Circadian Rhythms in a Tissue- and Isoform-Specific Manner
Jee-Hyun Um, Julie S. Pendergast, Danielle A. Springer, Marc Foretz, Benoit Viollet, Alexandra Brown, Myung K. Kim, Shin Yamazaki, Jay H. Chung
Research Article | published 31 Mar 2011 | PLOS ONE
10.1371/journal.pone.0018450
Age-Related Changes in the Epithelial and Stromal Compartments of the Mammary Gland in Normocalcemic Mice Lacking the Vitamin D3 Receptor
JoEllen Welsh, Lindsay N. Zinser, Laurel Mianecki-Morton, Jamie Martin, Susan E. Waltz, Howard James, Glendon M. Zinser
Research Article | published 26 Jan 2011 | PLOS ONE
10.1371/journal.pone.0016479
Postnatal PPARδ Activation and Myostatin Inhibition Exert Distinct yet Complimentary Effects on the Metabolic Profile of Obese Insulin-Resistant Mice
Barbara L. Bernardo, Timothy S. Wachtmann, Patricia G. Cosgrove, Max Kuhn, Alan C. Opsahl, Kyle M. Judkins, Thomas B. Freeman, John R. Hadcock, Nathan K. LeBrasseur
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Dietary Quercetin Supplementation in Mice Increases Skeletal Muscle PGC1α Expression, Improves Mitochondrial Function and Attenuates Insulin Resistance in a Time-Specific Manner
Tara M. Henagan, Natalie R. Lenard, Thomas W. Gettys, Laura K. Stewart
Research Article | published 21 Feb 2014 | PLOS ONE
10.1371/journal.pone.0089365
Elevated Mitochondrial Oxidative Stress Impairs Metabolic Adaptations to Exercise in Skeletal Muscle
Justin D. Crane, Arkan Abadi, Bart P. Hettinga, Daniel I. Ogborn, Lauren G. MacNeil, Gregory R. Steinberg, Mark A. Tarnopolsky
Research Article | published 06 Dec 2013 | PLOS ONE
10.1371/journal.pone.0081879
Peripheral Reduction of FGFR4 with Antisense Oligonucleotides Increases Metabolic Rate and Lowers Adiposity in Diet-Induced Obese Mice
Xing Xian Yu, Lynnetta M. Watts, Vara Prasad Manchem, Kaushik Chakravarty, Brett P. Monia, Michael L. McCaleb, Sanjay Bhanot
Research Article | published 29 Jul 2013 | PLOS ONE
10.1371/journal.pone.0066923
Gene Dosage Effects at the Imprinted Gnas Cluster
Simon T. Ball, Michelle L. Kelly, Joan E. Robson, Martin D. Turner, Jackie Harrison, Lynn Jones, Diane Napper, Colin V. Beechey, Tertius Hough, Antonius Plagge, Bruce M. Cattanach, Roger D. Cox, Jo Peters
Research Article | published 18 Jun 2013 | PLOS ONE
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Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury
Sanjoy Roychowdhury, Rebecca L. McCullough, Carlos Sanz-Garcia, Paramananda Saikia, Naim Alkhouri, Ammar Matloob, Katherine A. Pollard, Megan R. McMullen, Colleen M. Croniger, Laura E. Nagy
Hepatology, 17 July 2016
Hypoxia-Induced Intrauterine Growth Restriction Increases the Susceptibility of Rats to High-Fat Diet–Induced Metabolic Syndrome
Christian F. Rueda-Clausen, Vernon W. Dolinsky, Jude S. Morton, Spencer D. Proctor, Jason R.B. Dyck and Sandra T. Davidge
Diabetes February 2011 vol. 60 no. 2 507-516
Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
V. B. Matthews, T. L. Allen, S. Risis, M. H. S. Chan, D. C. Henstridge, N. Watson, L. A. Zaffino, J. R. Babb, J. Boon and P. J. Meikle, et al.
DIABETOLOGIA Volume 53, Number 11, 2431-2441
Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/– Mice: A Role of Lipid Mobilization and Inflammation
Fen Xu, Zhanguo Gao, Jin Zhang, Chantal A. Rivera, Jun Yin, Jianping Weng and Jianping Ye
Endocrinology Vol. 151, No. 6 2504-2514
Hypothalamic Actions of Tumor Necrosis Factor Provide the Thermogenic Core for the Wastage Syndrome in Cachexia
Ana Paula Arruda, Marciane Milanski, Talita Romanatto, Carina Solon, Andressa Coope, Luciane C. Alberici, William T. Festuccia, Sandro M. Hirabara, Eduardo Ropelle, Rui Curi, José B. Carvalheira, AnÃbal E. Vercesi and Licio A. Velloso
Endocrinology Vol. 151, No. 2 683-694
Remodeling of Hepatic Metabolism and Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides
Chika Watanabe, Yusuke Seino, Hiroki Miyahira, Michiyo Yamamoto, Ayako Fukami, Nobuaki Ozaki, Yoshiko Takagishi, Jun Sato, Tsutomu Fukuwatari, Katsumi Shibata, Yutaka Oiso, Yoshiharu Murata and Yoshitaka Hayashi
Diabetes January 2012 vol. 61 no. 1 74-84
Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle
Bolormaa Vandanmagsar, Jaycob D. Warfel, Shawna E. Wicks, Sujoy Ghosh, J. Michael Salbaum, David Burk, Olga S. Dubuisson, Tamra M. Mendoza, Jingying Zhang, Robert C. Noland, Randall L. Mynatt
Cell Reports, 12 May 2016
Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis
Moreshwar S. Desai, Zainuer Shabier, Michael Taylor, Fong Lam, Sundararajah Thevananther, Astrid Kosters, Saul J. Karpen
Issue
Hepatology
Volume 51, Issue 6, pages 2097-2107, June 2010
Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in obese versus lean mice
Jason M Tanner, Devin T Kearns, Bum Jun Kim, Crystal Sloan, Zhanjun Jia, Tianxin Yang, E Dale Abel and J David Symonsz
Exp. Biol. Med. 2010;235:1489-1497
Y2 receptor signalling in NPY neurons controls bone formation and fasting induced feeding but not spontaneous feeding
Yue Qi, Melissa Fu, Herbert Herzog
Neuropeptides, 27 September 2015
Hypothalamic PKA regulates leptin sensitivity and adiposity
Linghai Yang, G. Stanley McKnight
Nature Communications, Vol. 6, 18 September 2015
Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure
Jarrad M Scarlett, Darren D Bowe, Xinxia Zhu, Ayesha K Batra, Wilmon F Grant and Daniel L Marks
J Endocrinol July 1, 2010 206 121-130
Body temperature as a mouse pharmacodynamic response to bombesin receptor subtype-3 agonists and other potential obesity treatments
Joseph M. Metzger, Karen Gagen, Kate A. Raustad, Liming Yang, Amanda White, Sheng-Ping Wang, Stephanie Craw, Ping Liu, Thomas Lanza, Linus S. Lin, Ravi P. Nargund, Xiao-Ming Guan, Alison M. Strack, and Marc L. Reitman
AJP - Endo November 1, 2010 vol. 299 no. 5 E816-E824
Alterations in Skeletal Muscle Fatty Acid Handling Predisposes Middle-Aged Mice to Diet-Induced Insulin Resistance
Debby P.Y. Koonen, Miranda M.Y. Sung, Cindy K.C. Kao, Vernon W. Dolinsky, Timothy R. Koves, Olga Ilkayeva, René L. Jacobs, Dennis E. Vance, Peter E. Light, Deborah M. Muoio, Maria Febbraio and Jason R.B. Dyck
Diabetes June 2010 vol. 59 no. 6 1366-1375
Paraventricular NUCB2/nesfatin-1 supports oxytocin and vasopressin neurons to control feeding behavior and fluid balance in male mice
Masanori Nakata, Darambazar Gantulga, Putra Santoso, Boyang Zhang, Chiaki Masuda, Masatomo Mori, Takashi Okada, and Toshihiko Yada
Endocrinology, 13 April 2016
O2max and exercise capacity despite coronary atherosclerosis' target='_blank' style='color: red;'>Exercise capacity and cardiac hemodynamic response in female ApoE/LDLR-/- mice: a paradox of preserved V'O2max and exercise capacity despite coronary atherosclerosis
M. Wojewoda, U. Tyrankiewicz, P. Gwozdz, T. Skorka, M. Jablonska, A. Orzylowska, K. Jasinski, A. Jasztal, K. Przyborowski, R. B. Kostogrys, J. A. Zoladz, S. Chlopicki
Scientific Reports, Vol. 6, 25 April 2016
Combined pharmacological activation of AMPK and PPARδ potentiates the effects of exercise in trained mice
Mark Christian C. Manio, Kazuo Inoue, Mina Fujitani, Shigenobu Matsumura, Tohru Fushiki
Physiological Reports, Vol. 4, 20 March 2016
Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor
Hirohide Nambu, Miyuki Fukushima, Hirohiko Hikichi, Takao Inoue, Norihiro Nagano, Yoshio Tahara, Tadahiro Nambu, Junko Ito, Yoshihiro Ogawa, Satoshi Ozaki, Hisashi Ohta
Life Sciences
Volume 89, Issues 21-22, 21 November 2011, Pages 765-772
Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is a Cell-Autonomous Regulator of Lipolysis Essential for Adipocyte Differentiation
Weiqin Chen, Benny Chang, Pradip Saha, Sean M. Hartig, Lan Li, Vasumathi Theegala Reddy, Yisheng Yang, Vijay Yechoor, Michael A. Mancini and Lawrence Chan
Mol. Cell. Biol. March 2012 vol. 32 no. 6 1099-1111
Nutrient Selection in the Absence of Taste Receptor Signaling
Xueying Ren, Jozélia G. Ferreira, Ligang Zhou, Sara J. Shammah-Lagnado, Catherine W. Yeckel, and Ivan E. de Araujo
The Journal of Neuroscience, June 9, 2010, 30(23):8012-8023
LACK OF cAMP RESPONSE ELEMENT BINDING PROTEIN (CREB1) IN THE
HYPOTHALAMUS CAUSES OBESITY
Franck Chiappini, Lucas L. Cunha, Jamie C. Harris, Anthony N. Hollenberg
January 5, 2011, doi: 10.1074/jbc.M110.178186
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Critical Role of the Src Homology 2 (SH2) Domain of Neuronal SH2B1 in the Regulation of Body Weight and Glucose Homeostasis in Mice
David L. Morris, Kae Won Cho and Liangyou Rui
Endocrinology Vol. 151, No. 8 3643-3651
Daily energy balance in growth hormone receptor/binding protein (GHR -/-) gene-disrupted mice is achieved through an increase in dark-phase energy efficiency
Kenneth A. Longo, Darlene E. Berryman, c, Bruce Kelder, Soratree Charoenthongtrakul, Peter S. DiStefano, Brad J. Geddes and John J. Kopchick
Growth Hormone & IGF Research
Volume 20, Issue 1, February 2010, Pages 73-79
Adult-onset PYY overexpression in mice reduces food intake and increases lipogenic capacity
Yan-Chuan Shi, Constanze Maria Hammerle, I-Chieh Jennifer Lee, Nigel Turner, Amy D. Nguyen, Sabrina J. Riepler, Shu Lin, Amanda Sainsbury, Herbert Herzog, Lei Zhang
Neuropeptides
Volume 46, Issue 4, August 2012, Pages 173-182
Protein Malnutrition during Pregnancy in C57BL/6J Mice Results in Offspring with Altered Circadian Physiology before Obesity
Gregory M. Sutton, Armand V. Centanni and Andrew A. Butler
Endocrinology Vol. 151, No. 4 1570-1580
A Selective Cannabinoid-1 Receptor Antagonist, PF-95453, Reduces Body Weight and Body Fat to a Greater Extent than Pair-Fed Controls in Obese Monkeys
Janice D. Wagner, Li Zhang, Kylie Kavanagh, Gina M. Ward, Janice E. Chin, John R. Hadcock, Bruce J. Auerbach and H. James Harwood Jr.
JPET October 2010 vol. 335 no. 1 103-113
Genetic ablation of calcium-independent phospholipase A2{Gamma} prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation
David J. Mancuso, Harold F. Sims, Kui Yang, Michael A. Kiebish, Xiong Su, Christopher M. Jenkins, Shaoping Guan, Sung Ho Moon, Terri Pietka, Fatiha Nassir, Timothy Schappe, Kristin Moore, Xianlin Han, Nada A. Abumrad and Richard W. Gross
J. Biol. Chem. jbc.M110.115766. First Published on September 3, 2010
Acute and chronic elevation of erythropoietin in the brain improves exercise performance in mice without inducing erythropoiesis
Beat Schuler, Johannes Vogel, Beat Grenacher, Robert A. Jacobs, Margarete Arras†and Max Gassmann
September 2012
The FASEB Journal
vol. 26 no. 9 3884-3890
Heart-type Fatty Acid-binding Protein Is Essential for Efficient Brown Adipose Tissue Fatty Acid Oxidation and Cold Tolerance
Laurent Vergnes, Robert Chin, Stephen G. Young and Karen Reue
January 7, 2011 The Journal of Biological Chemistry, 286, 380-390.
Knockdown of Natural Voluntary Running's Caloric Expenditure causes Obesity in High-fat Fed C57BL/6 Mice
Booth, Frank W. FACSM; Naples, Scott P.
Medicine & Science in Sports & Exercise:
October 2010 - Volume 42 - Issue 10 - p 52
TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet
Federica Cioffi, Shitalkumar P. Zambad, Laxmikant Chhipa, Rosalba Senese, Rosa Anna Busiello, Davinder Tuli, Siralee Munshi, Maria Moreno, Assunta Lombardi, Ramesh C. Gupta, Vijay Chauthaiwale, Chaitanya Dutt, Pieter de Lange, Elena Silvestri, Antonia Lanni and Fernando Goglia
The FASEB Journal
vol. 24 no. 9 3451-3461
Overexpression of nuclear receptor SHP in adipose tissues affects diet-induced obesity and adaptive thermogenesis
Imene Tabbi-Anneni, Robert Cooksey, Viswanath Gunda, Shiguo Liu, Aubrey Mueller, Guisheng Song, Donald A. McClain, and Li Wang
AJP - Endo May 2010 vol. 298 no. 5 E961-E970
Molecular Characterization of Skeletal Muscle Atrophy in the R6/2 Mouse Model of Huntington's Disease
Pengxiang She, Zhiyou Zhang, Deanna Marchionini, William C Diaz, Thomas L. Jetton, Scot R. Kimball, Thomas C. Vary, Charles H. Lang, and Christopher J Lynch
AJP - Endo April 2011 ajpendo.00630.2010
Type 2 Corticotropin-Releasing Factor Receptor in the Ventromedial Nucleus of Hypothalamus Is Critical in Regulating Feeding and Lipid Metabolism in White Adipose Tissue
Hongxia Chao, Michael Digruccio, Peilin Chen and Chien Li
Endocrinology January 1, 2012 vol. 153 no. 1 166-176
Coordinated Regulation of Hepatic Energy Stores by Leptin and Hypothalamic Agouti-Related Protein
James P. Warren, Jillian M. Varonin, Sofie S. Neilsen, Louise E. Olofsson, Christopher B. Kaelin, Streamson Chua Jr., Gregory S. Barsh, Suneil K. Koliwad, and Allison W. Xu
The Journal of Neuroscience, July 17, 2013 - 33(29):11972-11985
Metabolic effects of estrogen substitution in combination with targeted exercise training on the therapy of obesity in ovariectomized Wistar rats
Nora Zoth, Carmen Weigt, Sinan Zengin, Oliver Selder, Nadine Selke, Michael Kalicinski, Marion Piechotta, Patrick Diel
The Journal of Steroid Biochemistry and Molecular Biology
Volume 130, Issues 1-2, May 2012, Pages 64-72
High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice
Bei-Ying Qiu, Nigel Turner, Yuan-Yuan Li, Min Gu, Meng-Wei Huang, Fang Wu, Tao Pang, Fa-Jun Nan, Ji-Ming Ye, Jing-Ya Li and Jia Li
Diabetes January 2010 vol. 59 no. 1 256-265
Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity
Akinori Takahashi, Shungo Adachi, Masahiro Morita, Miho Tokumasu, Tohru Natsume, Toru Suzuki, Tadashi Yamamoto
Cell Reports, 17 December 2015
Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system
Minji Kim, Tsuyoshi Goto, Rina Yu, Kunitoshi Uchida, Makoto Tominaga, Yuriko Kano, Nobuyuki Takahashi, Teruo Kawada
Scientific Reports, 17 December 2015
PPARγ antagonist Gleevec improves insulin sensitivity and promotes the browning of white adipose tissue
Sunsil Choi, Eun-Sun Kim, Ji-Eun Jung, David P. Marciano, Ala Jo, Ja Young Koo, Soo Youn Choi, Yong Ryoul Yang, Hyun-Jun Jang, Eung-Kyun Kim, Jiyoung Park, Hyug Moo Kwon, In Hee Lee, Seung Bum Park, Kyung-Jae Myung, Pann-Ghill Suh, Patrick R. Griffin, Jang Hyun Choi
Diabetes, 6 January 2016
Dual Modulation of Nociception and Cardiovascular Reflexes during Peripheral Ischemia through P2Y1 Receptor-Dependent Sensitization of Muscle Afferents
Luis F. Queme, Jessica L. Ross, Peilin Lu, Renita C. Hudgins, Michael P. Jankowski
The Journal of Neuroscience, 6 January 2016
The nutrient and energy sensor Sirt1 regulates the hypothalamic-pituitary-adrenal (HPA) axis by altering the production of the prohormone convertase 2 (PC2) essential in the maturation of corticotropin releasing hormone (CRH) from its prohormone in male rats
Anika M. Toorie, Nicole E. Cyr, Jennifer S. Steger, Ross Beckman, George Farah, Eduardo A. Nillni
The Journal of Biological Chemistry, 11 January 2016
Effects of dietary phosphate on glucose and lipid metabolism
Maerjianghan Abuduli, Hirokazu Ohminami, Tamaki Otani, Hitoshi Kubo, Haruka Ueda, Yoshichika Kawai, Masashi Masuda, Hisami Yamanaka-Okumura, Hiroshi Sakaue, Hironori Yamamoto, Eiji Takeda, Yutaka Taketani
American Journal of Physiology - Endocrinology and Metabolism, 19 January 2016
17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization
Michael B. Stout, Frederik J. Steyn, Michael J. Jurczak, Joao-Paulo G. Camporez, Yi Zhu, John R. Hawse, Diana Jurk, Allyson K. Palmer, Ming Xu, Tamar Pirtskhalava, Glenda L. Evans, Roberta de Souza Santos, Aaron P. Frank, Thomas A. White, David G. Monroe, Ravinder J. Singh, Grace Casaclang-Verzosa, Jordan D. Miller, Deborah J. Clegg, Nathan K. LeBrasseur, Thomas von Zglinicki, Gerald I. Shulman, Tamara Tchkonia, James L. Kirkland
The Journals of Gerontology: Series A, 24 January 2016
Dietary fat and corticosterone levels are contributing factors to meal anticipation
Sara Namvar, Amy Gyte, Mark Denn, Brendan Leighton, Hugh D. Piggins
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 28 January 2016
A mouse model for a partially inactive obesity-associated human MC3R variant
Bonggi Lee, Jashin Koo, Joo Yun Jun, Oksana Gavrilova, Yongjun Lee, Arnold Y. Seo, Dezmond C. Taylor-Douglas, Diane C. Adler-Wailes, Faye Chen, Ryan Gardner, Dimitri Koutzoumis, Roya Sherafat Kazemzadeh, Robin B. Roberson, Jack A. Yanovski
Nature Communications, Vol. 7, No. 10522, 28 January 2016
Synergistic effects of genetic beta cell dysfunction and maternal glucose intolerance on offspring metabolic phenotype in mice
S. M. Lau, S. Lin, R. A. Stokes, K. Cheng, P. A. Baldock, R. F. Enriquez, M. McLean, N. W. Cheung, A. Sainsbury and F. J. Gonzalez, et al.
DIABETOLOGIA DOI: 10.1007/s00125-010-1998-z
Functional properties of Claramine: A novel PTP1B inhibitor and insulin-mimetic compound
Zhaohong Qin, Nihar R. Pandey, Xun Zhou, Chloe A. Stewart, Aswin Hari, Hua Huang, Alexandre F.R. Stewart, Jean Michel Brunel, Hsiao-Huei Chen
Biochemical and Biophysical Research Communications, 23 January 2015
Early leptin intervention reverses perturbed energy balance regulating hypothalamic neuropeptides in the pre- and postnatal calorie-restricted female rat offspring
Leena Caroline Gibson, Bo-Chul Shin, Yun Dai, William Freije, Sudatip Kositamongkol, John Cho1 andSherin U. Devaskar
Journal of Neuroscience Research, 29 JAN 2015, DOI: 10.1002/jnr.23560
Strain variation in the adaptation of C57Bl6 and BALBc mice to chronic hypobaric hypoxia
Nathan Cramer, Xiufen Xu, Christine Christensen, Alexis Bierman, Clarke Tankersley, Zygmunt Galdzicki
Physiology & Behavior, 31 January 2015
Neonatal Hyperoxic Lung Injury Favorably Alters Adult Right Ventricular Remodeling Response to Chronic Hypoxia Exposure
Kara N. Goss , Anthony R Cucci , Amanda Jo Fisher , Marjorie Albrecht , Andrea L Frump , Roziya Tursunova , Yong Gao , Mary Beth Brown , Irina Petrache , Robert S. Tepper , Shawn Kristopher Ahlfeld , Tim Lahm
American Journal of Physiology - Lung Cellular and Molecular Physiology Published 6 February 2015 Vol. no. , DOI: 10.1152/ajplung.00276.2014
Carbon Monoxide Improves Cardiac Function and Mitochondrial Population Quality in a Mouse Model of Metabolic Syndrome
Steve Lancel, David Montaigne, Xavier Marechal, Camille Marciniak, Sidi Mohamed Hassoun, Brigitte Decoster, Caroline Ballot, Caroline Blazejewski, Delphine Corseaux, Bernadette Lescure, Roberto Motterlini, Remi Neviere
2012 PLoS ONE 7(8): e41836. doi:10.1371/journal.pone.0041836
Disassociation of Muscle Insulin Signaling and Insulin-Stimulated Glucose Uptake during Endotoxemia
Kimberly X. Mulligan, R. Tyler Morris, Yolanda F. Otero, David H. Wasserman, Owen P. McGuinness
2012 PLoS ONE 7(1): e30160. doi:10.1371/journal.pone.0030160
Metabolic Consequences of High-Fat Diet Are Attenuated by Suppression of HIF-1α
Mi-Kyung Shin, Luciano F. Drager, Qiaoling Yao, Shannon Bevans-Fonti, Doo-Young Yoo, Jonathan C. Jun, Susan Aja, Sanjay Bhanot, Vsevolod Y. Polotsky
2012 PLoS ONE 7(10): e46562. doi:10.1371/journal.pone.0046562
CTRP1 Protein Enhances Fatty Acid Oxidation via AMP-activated Protein Kinase (AMPK) Activation and Acetyl-CoA Carboxylase (ACC) Inhibition
Jonathan M. Peterson, Susan Aja, Zhikui Wei and G. William Wong
January 6, 2012 The Journal of Biological Chemistry, 287, 1576-1587.
The Isoflavone-Rich Fraction of the Crude Extract of the Puerariae Flower Increases Oxygen Consumption and BAT UCP1 Expression in High-Fat Diet-Fed Mice
Tomoyasu Kamiya, Rika Nagamine, Mayu Sameshima-Kamiya, Masahito Tsubata, Motoya Ikeguchi, Kinya Takagaki
Global Journal of Health Science Vol 4, No 5 (2012)
Dietary cystine level affects metabolic rate and glycaemic control in adult mice
Amany K. Elshorbagy, Chris Church, Maria Valdivia-Garcia, A. David Smith, Helga Refsum, Roger Cox
The Journal of Nutritional Biochemistry
Volume 23, Issue 4, April 2012, Pages 332-340
Resting Energy Expenditure and Energetic Cost of Feeding Are Augmented after Roux-en-Y Gastric Bypass in Obese Mice
Eirini Nestoridi, Stephanie Kvas, John Kucharczyk and Nicholas Stylopoulos
Endocrinology May 1, 2012 vol. 153 no. 5 2234-2244
Absence of uncoupling protein-3 leads to greater activation of an adenine nucleotide translocase-mediated proton conductance in skeletal muscle mitochondria from calorie restricted mice
Lisa Bevilacqua, Erin L. Seifert, Carmen Estey, Martin F. Gerrits and Mary-Ellen Harper
Biochimica et Biophysica Acta (BBA) - Bioenergetics Volume 1797, Issue 8, August 2010, Pages 1389-1397
Beneficial effects of combinatorial micronutrition on body fat and atherosclerosis in mice
Ilhem El Kochairi, Alexandra Montagner, Gianpaolo Rando, Christine Lohmann, Christian M. Matter and Walter Wahli
Cardiovasc Res (2011) 91 (4): 732-741.
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Obesity impairs skeletal muscle AMPK signaling during exercise: role of AMPK{alpha}2 in the regulation of exercise capacity in vivo
R S Lee-Young, J E Ayala, P T Fueger, W H Mayes, L Kang and D H Wasserman
International Journal of Obesity , (16 November 2010)
Tlr2 is critical for diet-induced metabolic syndrome in a murine model
Ryan W. Himes, and C. Wayne Smith
March 2010 The FASEB Journal vol. 24 no. 3 731-739
Attainment of Brown Adipocyte Features in White Adipocytes of Hormone-Sensitive Lipase Null Mice
Kristoffer Ström, Ola Hansson, Stéphanie Lucas, Pernilla Nevsten, Céline Fernandez, Cecilia Klint, Sofia Movérare-Skrtic, Frank Sundler, Claes Ohlsson, Cecilia Holm
PLoS ONE 3(3): e1793
Chronic Exposure to the Herbicide, Atrazine, Causes Mitochondrial Dysfunction and Insulin Resistance
Soo Lim, Sun Young Ahn, In Chan Song, Myung Hee Chung, Hak Chul Jang, Kyong Soo Park, Ki-Up Lee, Youngmi Kim Pak, Hong Kyu Lee
PLoS ONE 4(4): e5186
Hyperleptinemia Is Required for the Development of Leptin Resistance
Zachary A. Knight, K. Schot Hannan, Matthew L. Greenberg, Jeffrey M. Friedman
PLoS ONE 5(6): e11376
Skeletal muscle growth and fiber composition in mice are regulated through the transcription factors STAT5a/b: linking growth hormone to the androgen receptor
Peter Klover, Weiping Chen, Bing-Mei Zhu and Lothar Hennighausen
The FASEB Journal. 2009;23:3140-3148
Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese Mice
Izumiya Y, T Hopkins, C Morris, K Sato, L Zeng, J Viereck, JA Hamilton, N Ouchi, NK LeBrasseur, K Walsh
Cell Metab, 7:159-172, 2008.
Central Injection of the Stable Somatostatin Analog ODT8-SST Induces a Somatostatin2 Receptor-Mediated Orexigenic Effect: Role of Neuropeptide Y and Opioid Signaling Pathways in Rats
Andreas Stengel, Tamer Coskun, Miriam Goebel, Lixin Wang, Libbey Craft, Jorge Alsina-Fernandez, Jean Rivier and Yvette Taché
Endocrinology Vol. 151, No. 9 4224-4235
Suppression of the aging-associated decline in physical performance by a combination of resveratrol intake and habitual exercise in senescence-accelerated mice
Takatoshi Murase, Satoshi Haramizu, Noriyasu Ota and Tadashi Hase
Biogerontology Volume 10, Number 4 / August, 2009 Pages 423-434
Hypermetabolism in a triple-transgenic mouse model of Alzheimer's disease
Elysse M. Knighta, Alexei Verkhratskya, Simon M. Luckmana, Stuart M. Allana and Catherine B. Lawrence
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Mechanisms of Glucose Homeostasis After Roux-en-Y Gastric Bypass Surgery in the Obese, Insulin-Resistant Zucker Rat
Katia Meirelles, Tamer Ahmed, Derek M. Culnan, Christopher J. Lynch, Charles H. Lang, and Robert N. Cooney
Ann Surg. 2009 February; 249(2): 277-285.
High levels of whole-body energy expenditure are associated with a lower coupling of skeletal muscle mitochondria in C57Bl/6 mice
Sjoerd A.A. van den Berg, Miranda Nabben, Silvia Bijland, Peter J. Voshol, Jan Bert van Klinken, Louis M. Havekes, Johannes A. Romijn, Joris Hoeks, Matthijs K. Hesselink, Patrick Schrauwen, Ko Willems van Dijk
Metabolism - Clinical and Experimental - November 2010 (Vol. 59, Issue 11, Pages 1612-1618
Central Neuromedin U Signaling in Body Weight and Energy Balance Regulation: Evidence from NMU Receptor 2 Deletion and Chronic Central NMU Treatment in Mice
Emil Egecioglu, Karolina Ploj, Xiufeng Xu, Mikael Bjursell, Nicolas salome1, Niklas Andersson, Claes Ohlsson, Magdalena Taube, Caroline Hansson, Mohammad Bohlooly, David G.A. Morgan, and Suzanne Lee Dickson
Am J Physiol Endocrinol Metab (July 7, 2009)
Can physical exercise during gestation attenuate the effects of a maternal perinatal low-protein diet on oxygen consumption in rats?
Marco Fidalgo Amorim José Antonio dos Santos, Sandro Massao Hirabara, Elizabeth Nascimento, Sandra Lopes de Souza, Raul Manhães de Castro, Rui Curi and Carol Góis Leandro
Experimental Physiology, August 1, 2009 94, 906-913.
A Novel Anti-inflammatory Role for Spleen-Derived Interleukin-10 in Obesity-Induced Inflammation in White Adipose Tissue and Liver
Koro Gotoh, Megumi Inoue, Takayuki Masaki, Seiichi Chiba, Takanobu Shimasaki, Hisae Ando, Kansuke Fujiwara, Isao Katsuragi, Tetsuya Kakuma, Masataka Seike, Toshiie Sakata and Hironobu Yoshimatsu
Diabetes August 2012 vol. 61 no. 8 1994-2003
Central angiotensin AT1 receptors are involved in metabolic adjustments in response to graded exercise in rats.
Leite LH, Lacerda AC, Balthazar CH, Marubayashi U, Coimbra CC.
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Paraquat (PQ)-induced pulmonary fibrosis increases exercise metabolic cost, reducing aerobic performance in rats
Ana Cristina Rodrigues Lacerda, Maria da Glória Rodrigues-Machado, Polyana Leite Mendes, Rômulo Dias Novaes, Giovanna Marcella Cavalcante Carvalho, Walter Araujo Zin, Fernando Gripp and Cândido Celso Coimbra
The Journal of Toxicological Sciences
Vol. 34 (2009) , No. 6 December 671-679
Acute or Chronic Upregulation of Mitochondrial Fatty Acid Oxidation Has No Net Effect on Whole-Body Energy Expenditure or Adiposity
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Regulation of Skeletal Muscle Oxidative Capacity and Muscle Mass by SIRT3
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The Glucagon-like Peptide-1 Receptor Regulates Endogenous Glucose Production and Muscle Glucose Uptake Independent of its Incretin Action
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Endocrinology Vol. 150, No. 3 1155-1164
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Fibroblast Growth Factor 21 Corrects Obesity in Mice
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Endocrinology Vol. 149, No. 12 6018-6027
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Thyroid Hormone Receptor-α Gene Knockout Mice Are Protected from Diet-Induced Hepatic Insulin Resistance
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Tea catechin ingestion combined with habitual exercise suppresses the aging-associated decline in physical performance in senescence-accelerated mice
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PYY3-36 injection in mice produces an acute anorexigenic effect followed by a delayed orexigenic effect not observed with other anorexigenic gut hormones
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Effects of a Single and Short-Term Ingestion of Diacylglycerol on Fat Oxidation in Rats
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Increased metabolism in the R6/2 mouse model of Huntington’s disease
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30 Days of Continuous Olanzapine Infusion Determines Energy Imbalance, Glucose Intolerance, Insulin Resistance, and Dyslipidemia in Mice
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Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology Volume 141, Issue 3, July 2005, Pages 257-263
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Amylin-Mediated Restoration of Leptin Responsiveness in Diet-Induced Obesity: Magnitude and Mechanisms
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Decreased food intake rather than zinc deficiency is associated with changes in plasma leptin, metabolic rate, and activity levels in zinc deficient rats
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Exercise and Green Tea Extract Stimulate Fat Oxidation and Prevent Obesity in Mice
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Adverse Cardiovascular Effects with Acute Particulate Matter and Ozone Exposures: Interstrain Variation in Mice
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Environmental Health Perspectives Volume 116, Number 8, August 2008
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Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice
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Differential Antidiabetic Efficacy of Incretin Agonists Versus DPP-4 Inhibition in High Fat–Fed Mice
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Diabetes 57:190-198, 2008
Resistance to Diet-Induced Obesity and Improved Insulin Sensitivity in Mice With a Regulator of G Protein Signaling–Insensitive G184S Gnai2 Allele
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1, Kuljeet Kaur
1, Isabelle Gerin
2, Ormond A. MacDougald
2,3, and Richard R. Neubig
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Diabetes 57:77-85, 2008
Pharmacologic Inhibition of Ghrelin Receptor Signaling Is Insulin Sparing and Promotes Insulin Sensitivity
Kenneth A. Longo, Elizabeth K. Govek, Anna Nolan, Thomas McDonagh, Soratree Charoenthongtrakul, Derek J. Giuliana, Kristen Morgan, Jeffrey Hixon, Chaoseng Zhou, Bruce Kelder, John J. Kopchick, Jeffrey O. Saunders, Manuel A. Navia, Rory Curtis, Peter S. DiStefano and Brad J. Geddes
JPET October 2011 vol. 339 no. 1 115-124
Dysregulation Editing of Serotonin 2C Receptor mRNAs Results in Energy Dissipation and Loss of Fat Mass
Yukio Kawahara,
1 Adda Grimberg,
2 Sarah Teegarden,
3 Cedric Mombereau,
4 Sui Liu,
1 Tracy L. Bale,
3 Julie A. Blendy,
4 and Kazuko Nishikura
1 The Journal of Neuroscience, Nov 26, 2008 - 28(48):12834-12844
Psychosocial stress affects energy balance in mice: Modulation by social status
A. Moles, A. Bartolomucci, L. Garbugino, R. Conti, A. Caprioli, R. Coccurello, R. Rizzi, B. Ciani and F.R. D'Amato
Psychoneuroendocrinology Volume 31, Issue 5, June 2006, Pages 623-633
Effects of leptin on energy metabolism in {beta}-less mice
CS Asensio
1,2, D Arsenijevic
2, L Lehr
3 J-P Giacobino
3, P Muzzin
1 and F Rohner-Jeanrenaud
2
Internation Journal of Obesity (2008) 32, 936-342
Glucocorticoid receptor dimerization is required for proper recovery of LPS-induced inflammation, sickness behavior and metabolism in mice
M N Silverman, P Mukhopadhyay, E Belyavskaya, L H Tonelli, B D Revenis, J H Doran, B E Ballard, J Tam, P Pacher and E M Sternberg
Molecular Psychiatry advance online publication 23 October 2012; doi: 10.1038/mp.2012.131
Chemical sympathectomy alters food intake and thermogenic responses to catecholamines in rats
Iván Villanueva, Manuel Piñón, LucÃa Quevedo-Corona, Rubén MartÃnez-Olivares and Radu Racotta
Life Sciences Volume 71, Issue 7, 5 July 2002, Pages 789-801
Characterization of Adult Ghrelin and Ghrelin Receptor Knockout Mice under Positive and Negative Energy Balance
Yuxiang Sun, Nancy F. Butte, Jose M. Garcia and Roy G. Smith
Endocrinology Vol. 149, No. 2 843-850
The role of mitochondrial glycerol-3-phosphate acyltransferase-1 in regulating lipid and glucose homeostasis in high-fat diet fed mice
Misak Yazdi, Andrea Ahnmark, Lena William-Olsson, Michael Snaith, Nigel Turner, Fredrik Osla, Marianne Wedin, Anna-Karin Asztély, Anders Elmgren, Mohammad Bohlooly-Y, Sandra Schreyer and Daniel Lindén
Biochemical and Biophysical Research Communications Volume 369, Issue 4, 16 May 2008, Pages 1065-1070
Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet
Michelle Lee,
1 Andrea Kim,1 Streamson C. Chua, Jr.,
2 Silvana Obici,
3 and Sharon L. Wardlaw
1
Am J Physiol Endocrinol Metab 293: E121-E131, 2007
The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse
Krister S Eriksson,
1 Shengwen Zhang,
1 Ling Lin,
1 Roxanne C Larivière,
2 Jean-Pierre Julien,
2 and Emmanuel Mignot
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BMC Neurosci. 2008; 9: 26.
Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice
Mikael Bjursell,
1 Anna-Karin Gerdin,
1 Christopher J. Lelliott,
1 Emil Egecioglu,
2 Anders Elmgren,
1 Jan Törnell,
1,2 Jan Oscarsson,
1,2 and Mohammad Bohlooly-Y
1,2
Am J Physiol Endocrinol Metab 294: E251-E260, 2008
Endurance Training Modulates Lymphocyte Function in Rats with Post-MI CHF
BATISTA, MIGUEL LUIZ JR.
1,3; SANTOS, RONALDO V. T.
1,2; LOPES, RENATO D.
4,5; LOPES, ANTONIO C.
5; COSTA ROSA, LUIS FERNANDO B. P.
1,+; SEELAENDER, MARILIA C. L.
1
Medicine & Science in Sports & Exercise. 40(3):549-556, March 2008.
Selection for Body Composition Does Not Affect Energetic Efficiency of Jejunal Glucose Uptake in Mice1,2
Yang-Kwang Fan
3, Warren J. Croom, Jr.
4,5, Linda R. Daniel, Anthony R. Bird
5, Betty L. Black*, Eugene J. Eisen and Brian W. McBride
Journal of Nutrition Vol. 126 No. 11 November 1996, pp. 2861-2866
Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome
Nathan C. Bingham, Kimberly K. Anderson, Anne L. Reuter, Nancy R. Stallings, and Keith L. Parker*
Endocrinology Vol. 149, No. 5 2138-2148
Triiodothyronine differentially regulates key metabolic factors in lean and obese cats
M. Hoenig, Z. Caffall and D.C. Ferguson
Domestic Animal Endocrinology Volume 34, Issue 3, April 2008, Pages 229-237
Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries
Henrik C. Nyström
a,*, Per Lindblom
b, Anna Wickman
a, Irene Andersson
a, Jenny Norlin
c, Jenny Fäldt
d, Per Lindahl
e, Ole Skøtt
f, Mattias Bjarnegard
e, Sharyn M. Fitzgerald
g, Kenneth Caidahl
h, Li-ming Gan
a, Christer Betsholtz
c and Göran Bergström
h
Cardiovascular Research 2006 71(3):557-565
Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice
Maria C. GarcÃa
1, Ingrid Wernstedt
1, Anna Berndtsson
1, Maria Enge
1, Michal Bell
2, Olof Hultgren
3, Michael Horn
4, Bo Ahrén
5, Sven Enerback
2, Claes Ohlsson
6, Ville Wallenius
1, and John-Olov Jansson
1
Diabetes 55:1205-1213, 2006
Increased Energy Expenditure, Dietary Fat Wasting, and Resistance to Diet-Induced Obesity in Mice Lacking Renin
Nobuyuki Takahashi, Feng Li, Kunjie Hua, Jianbei Deng, Chih-Hong Wang, Robert R. Bowers, Timothy J. Bartness, Hyung-Suk Kim and Joyce B. Harp
Cell Metabolism , Volume 6 , Issue 6 , Pages 506 - 512
Effect of cold on lipid peroxidation in the brown adipose tissue and liver of rats
Tadeusz Wlostowski, Elzbieta Bonda and Alicja Krasowska
Journal of Thermal Biology Volume 33, Issue 3, April 2008, Pages 180-184
Identification of Genes and Networks Driving Cardiovascular and Metabolic Phenotypes in a Mouse F2 Intercross
Jonathan M. J. Derry, Hua Zhong, Cliona Molony, Doug MacNeil, Debraj Guhathakurta, Bin Zhang, John Mudgett, Kersten Small, Lahcen El Fertak, Alain Guimond, Mohammed Selloum, Wenqing Zhao, Marie France Champy, Laurent Monassier, Tom Vogt, Doris Cully, Andrew Kasarskis, Eric E. Schadt
Research Article | published 14 Dec 2010 | PLOS ONE
10.1371/journal.pone.0014319
Mediation of burn-induced hypermetabolism by CRF receptor-2 activity
William T. Chance, Ramesh Dayal, Lou Ann Friend, Ingrid Thomas and Sulaiman Sheriff
Life Sciences Volume 80, Issue 11, 20 February 2007, Pages 1064-1072
Human IL6 enhances leptin action in mice
M. Sadagurski, L. Norquay, J. Farhang, K. D’Aquino, K. Copps, M. F. White
Diabetologia March 2010, Volume 53, Issue 3, pp 525-535,
Metabolic homeostasis and tissue renewal are dependent on {beta}1,6GlcNAc-branched N-glycans
Pam Cheung
2,3, Judy Pawling
2, Emily A Partridge
2,4, Balram Sukhu
2, Marc Grynpas
2,4 and James W Dennis
1,3,4
Glycobiology 2007 17(8):828-837
Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor {alpha}1
Maria Sjogren
1, 4, Anneke Alkemade
1, 4, Jens Mittag
1, Kristina Nordström
1, Abram Katz
2, Björn Rozell
3, Hakan Westerblad
2, Anders Arner
2 and Björn Vennström
1
The EMBO Journal (2007) 26, 4535-4545
Spontaneously reduced body temperature and gasping ability as a mechanism of extreme tolerance to asphyxia in neonatal rats
Justyna Rogalska and Michal Caputa
Journal of Thermal Biology Volume 30, Issue 5, July 2005, Pages 360-369
Effect of Lipid Infusion on Metabolism and Force of Rat Skeletal Muscles During Intense Contractions
LeonardoR. Silveira, Sandro M. Hirabara, Luciane C. Alberici1, Rafael H. Lambertucci, Carmem M. Peres, Hilton K. Takahashi, Adhemar Pettri, Tatiana Alba-Loureiro, Augusto D. Luchessi, Maria F. Cury-Boaventura, Anibal E. Vercesi1, Rui Curi
Cell Physiol Biochem 2007;20:213-226
Reduction of Low Molecular Weight Protein-tyrosine Phosphatase Expression Improves Hyperglycemia and Insulin Sensitivity in Obese Mice
Sanjay K. Pandey
1, Xing Xian Yu, Lynnetta M. Watts, M. Dodson Michael, Kyle W. Sloop, Amber R. Rivard, Thomas A. Leedom, Vara Prasad Manchem, Laura Samadzadeh, Robert A. McKay, Brett P. Monia, and Sanjay Bhanot
J. Biol. Chem., Vol. 282, Issue 19, 14291-14299, May 11, 2007
Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure*
Mitsuhiro Watanabe, Yasushi Horai, Sander M. Houten, Kohkichi Morimoto, Taichi Sugizaki, Eri Arita, Chikage Mataki, Hiroyuki Sato, Yusuke Tanigawara, Kristina Schoonjans, Hiroshi Itoh and Johan Auwerx
The Journal of Biological Chemistry, 286, 26913-26920. July 29, 2011
Chronic Treatment With Sildenafil Improves Energy Balance and Insulin Action in High Fat–Fed Conscious Mice
Julio E. Ayala
1, Deanna P. Bracy
1, Brianna M. Julien
1, Jeffrey N. Rottman
2, Patrick T. Fueger
3, and David H. Wasserman
1
Diabetes 56:1025-1033, 2007
Combination Therapy with Amylin and Peptide YY[3–36] in Obese Rodents: Anorexigenic Synergy and Weight Loss Additivity
Jonathan D. Roth, Todd Coffey, Carolyn M. Jodka, Holly Maier, Jennifer R. Athanacio, Christine M. Mack, Christian Weyer and David G. Parkes
Endocrinology Vol. 148, No. 12 6054-6061
Orexin A mediation of time spent moving in rats: Neural mechanisms
C.M. Kotz, C. Wang, J.A. Teske, A.J. Thorpe, C.M. Novak, K. Kiwaki and J.A. Levine
Neuroscience Volume 142, Issue 1, 29 September 2006, Pages 29-36
Thermogenesis activated by central melanocortin signaling is dependent on neurons in the rostral raphe pallidus (rRPa) area
Wei Fan, Shaun F. Morrison, Wei-Hua Cao and Pinxuan Yu
Brain Research Volume 1179, 7 November 2007, Pages 61-69
Incretin Receptors for Glucagon-Like Peptide 1 and Glucose-Dependent Insulinotropic Polypeptide Are Essential for the Sustained Metabolic Actions of Vildagliptin in Mice
Grace Flock, Laurie L. Baggio, Christine Longuet, and Daniel J. Drucker
Diabetes 56:3006-3013, 2007
Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice
K. Raddatz, N. Turner, G. Frangioudakis, B. M. Liao, D. J. Pedersen, J. Cantley, D. Wilks, E. Preston, B. D. Hegarty, M. Leitges, M. J. Raftery, T. J. Biden, C. Schmitz-Peiffer
Diabetologia
June 2011, Volume 54, Issue 6, pp 1447-1456
Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury
Yousuke T. Horikawa, Hemal H. Patel, Yasuo M. Tsutsumi, Michelle M. Jennings, Michael W. Kidd, Yasuko Hagiwara, Yoshihiro Ishikawa, Paul A. Insel and David M. Roth
Journal of Molecular and Cellular Cardiology Volume 44, Issue 1, January 2008, Pages 123-130
Peptide YY Regulates Bone Turnover in Rodents.
Katherine E. Wortley, Karen Garcia, Haruka Okamoto, Karen Thabet, Keith D. Anderson, Victor Shen, Jim P. Herman, David Valenzuela, George D. Yancopoulos, Matthias H. Tschöp, Andrew Murphy and Mark W. Sleeman
Gastroenterology Volume 133, Issue 5, November 2007, Pages 1534-1543
TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity
Tatsuya Kusudo, Zhonghua Wang, Atsuko Mizuno, Makoto Suzuki, and Hitoshi Yamashita
Journal of Applied Physiology April 1, 2012 vol. 112 no. 7 1223-1232
Hepatic and renal cadmium accumulation is associated with mass-specific daily metabolic rate in the bank vole (Clethrionomys glareolus)
Tadeusz Wlostowski, Ewa Chwelatiuk, Elzbieta Bonda, Alicja Krasowska and Jan Zukowski
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
Volume 141, Issue 1, May 2005, Pages 15-19
A model for obesity and gigantism due to disruption of the Ankrd26 gene
Tapan K. Bera*, Xiu-Fen Liu*, Masanori Yamada*, Oksana Gavrilova, Eva Mezey, Lino Tessarollo, Miriam Anver
¶, Yoonsoo Hahn*
,||, Byungkook Lee*, and Ira Pastan*
,**
PNAS | January 8, 2008 | vol. 105 | no. 1 | 270-275
Calorigenic effect of diiodothyronines in the rat
A Lanni, M Moreno, A Lombardi and F Goglia
J Physiol Vol 494, Issue Pt 3 pp 831-837
Genetically Altered Expression of Spermidine/Spermine N1-Acetyltransferase Affects Fat Metabolism in Mice via Acetyl-CoA*
Jason Jell
1, Salim Merali
1, Mary L. Hensen, Richard Mazurchuk
¶, Joseph A. Spernyak
¶, Paula Diegelman, Nicholas D. Kisie
l, Carlos Barrero, Kristin K. Deeb, Leena Alhonen
||, Mulchand S. Patel**, and Carl W. Porter
2
J. Biol. Chem., Vol. 282, Issue 11, 8404-8413, March 16, 2007
The metabolic profile of early Huntington's disease- a combined human and transgenic mouse study
Anna O.G. Goodman, Peter. R. Murgatroyd, Gema Medina-Gomez, Nigel I. Wood, Nicholas Finer, Antonio J. Vidal-Puig, A. Jennifer Morton and Roger A. Barker
Experimental Neurology Volume 210, Issue 2, April 2008, Pages 691-698
Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice
Michael J. Jurczak, Ann-Hwee Lee, Francois R. Jornayvaz, Hui-Young Lee, Andreas L. Birkenfeld, Blas A. Guigni, Mario Kahn, Varman T. Samuel, Laurie H. Glimcher and Gerald I. Shulman
The Journal of Biological Chemistry, January 20, 2012, 287, 2558-2567.
Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice
Katrine Almind*, Monia Manieri, William I. Sivitz, Saverio Cinti, and C. Ronald Kahn*
,¶
PNAS | February 13, 2007 | vol. 104 | no. 7 | 2366-2371
Is energy expenditure in the hamster primarily under homeostatic or circadian control?
Roberto Refinetti
1 and Michael Menaker*
The Journal of Physiology Volume 501 Issue 2 Page 449-453, June 1997
Characterization of diet-induced obese rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet
Jun Gao, Lorraine Ghibaudi, Margaret van Heek and Joyce J. Hwa
Brain Research Volume 936, Issues 1-2, 17 May 2002, Pages 87-90
SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice
Erin L. Seifert, Annabelle Z. Caron, Katy Morin, Josée Coulombe, Xiao Hong He, Karen Jardine, Danielle Dewar-Darch, Kim Boekelheide, Mary-Ellen Harper and Michael W. McBurney
The FASEB Journal
vol. 26 no. 2 555-566
Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance
Daniela M.L. Tsukumo
1, Marco A. Carvalho-Filho
1, José B.C. Carvalheira
1, PatrÃcia O. Prada
1, Sandro M. Hirabara
2, André A. Schenka
3, Eliana P. Araújo
1, José Vassallo
3, Rui Curi
2, LÃcio A. Velloso
1, and Mario J.A. Saad
1
Diabetes 56:1986-1998, 2007
Sex-Specific Effect of Estrogen Sulfotransferase on Mouse Models of Type 2 Diabetes
Jie Gao, Jinhan He, Xiongjie Shi, Maja Stefanovic-Racic, Meishu Xu, Robert Martin O’Doherty, Adolfo Garcia-Ocana and Wen Xie
Diabetes June 2012 vol. 61 no. 6 1543-1551
Continuous fat oxidation in acetyl–CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity
Cheol Soo Choi*, David B. Savage*, Lutfi Abu-Elheiga, Zhen-Xiang Liu*, Sheene Kim*, Ameya Kulkarni*, Alberto Distefano*, Yu-Jin Hwang*, Richard M. Reznick*, Roberto Codella*, Dongyan Zhang*, Gary W. Cline*, Salih J. Wakil, and Gerald I. Shulman*
,¶,||
PNAS | October 16, 2007 | vol. 104 | no. 42 | 16480-16485
Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance
Dongyan Zhang*, Zhen-Xiang Liu*, Cheol Soo Choi, Liqun Tian, Richard Kibbey, Jianying Dong*, Gary W. Cline, Philip A. Wood, and Gerald I. Shulman*
¶
PNAS | October 23, 2007 | vol. 104 | no. 43 | 17075-17080
Selection for Growth Does Not Affect Apparent Energetic Efficiency of Jejunal Glucose Uptake in Mice
Yang-Kwang Fan
3, Warren J. Croom, Jr.
4,5, Eugene J. Eisen, Linda R. Daniel, Betty L. Black* and Brian W. McBride
Journal of Nutrition Vol. 126 No. 11 November 1996, pp. 2851-2860
Macrophage Migration Inhibitory Factor Inhibition Is Deleterious for High-Fat Diet-Induced Cardiac Dysfunction
Aurore Palud, Camille Marciniak, David Montaigne, Xavier Marechal, Caroline Ballot, Sidi Mohamed Hassoun, Brigitte Decoster, Remi Neviere, Steve Lancel
Research Article | published 11 Mar 2013 | PLOS ONE
10.1371/journal.pone.0058718
Loss of Cytokine-STAT5 Signaling in the CNS and Pituitary Gland Alters Energy Balance and Leads to Obesity
Ji-Yeon Lee,
#1 Heike Muenzberg,
#2 Oksana Gavrilova,
#3 Jacquelyn A. Reed,
4 Darlene Berryman,
5 Eneida C. Villanueva,
2 Gwendolyn W. Louis,
2 Gina M. Leinninger,
2 Stefano Bertuzzi,
6 Randy J. Seeley,
4 Gertraud W. Robinson,
1 Martin G. Myers, Jr.,
2¶ and Lothar Hennighausen
1¶*
PLoS ONE. 2008; 3(2): e1639
Targeted Inactivation of GPR26 Leads to Hyperphagia and Adiposity by Activating AMPK in the Hypothalamus
Daohong Chen, Xiaolei Liu, Weiping Zhang, Yuguang Shi
Research Article | published 16 Jul 2012 | PLOS ONE
10.1371/journal.pone.0040764
SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice
Gino Boily,
1 Erin L. Seifert,
2 Lisa Bevilacqua,
2, Xiao Hong He,
1M Guillaume Sabourin,
1 Carmen Estey,
2, Cynthia Moffat,
1 Sean Crawford,
1 Sarah Saliba,
1 Karen Jardine,
1 Jian Xuan,
2 Meredith Evans,
2 Mary-Ellen Harper,
2 and Michael W. McBurney
1,2*
PLoS ONE. 2008; 3(3): e1759.
Genetic Disruption of Myostatin Reduces the Development of Proatherogenic Dyslipidemia and Atherogenic Lesions In Ldlr Null Mice
Powen Tu, Shalender Bhasin, Paul W. Hruz, Karen L. Herbst, Lawrence W. Castellani, Ning Hua, James A. Hamilton and Wen Guo
Diabetes August 2009 vol. 58 no. 8 1739-1748
Carnitine revisited: potential use as adjunctive treatment in diabetes
R. A. Power
1, 2, M. W. Hulver
3, J. Y. Zhang
1, 2, J. Dubois
1, 2, R. M. Marchand
1, 2, O. Ilkayeva
4, D. M. Muoio
4 and R. L. Mynatt
1, 2
Diabetologia Volume 50, Number 4 / April, 2007 Pages 824-832
Loss of Agouti-Related Peptide Does Not Significantly Impact the Phenotype of Murine POMC Deficiency
Marcus P. Corander, Debra Rimmington, Benjamin G. Challis, Stephen O'Rahilly and Anthony P. Coll
Endocrinology May 1, 2011 vol. 152 no. 5 1819-1828
Diet-induced obesity and hepatic steatosis in L-FABP-/- mice is abrogated with saturated but not polyunsaturated fat feeding and attenuated following cholesterol supplementation
Elizabeth Patton Newberry
1, Susan M. Kennedy
1, Yan Xie
1, Britni T. Sternard
1, Jianyang Luo
1, and Nicholas O. Davidson
1
Am J Physiol Gastrointest Liver Physiol (November 21, 2007)
The transcription factors Stat5a/b are not required for islet development but modulate pancreatic B-cell physiology upon aging
Ji-Yeon Lee, Oksana Gavrilova, Behrous Davani, Risu Na, Gertraud W. Robinson and Lothar Hennighausen
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Volume 1773, Issue 9, September 2007, Pages 1455-1461
Reduction of Hepatosteatosis and Lipid Levels by an Adipose Differentiation-Related Protein Antisense Oligonucleotide.
Y. Imai, G. Varela, M. Jackson, M. Graham, R. Crooke, R. Ahima
Gastroenterology , Volume 132 , Issue 5 , Pages 1947 - 1954
Bezafibrate improves bacterial lipopolysaccharide-induced dyslipidemia and anorexia in rats.
N. Harada, A. Kusuyama, M. Morishima, K. Okada, A. Takahashi, Y. Nakaya
Metabolism , Volume 56 , Issue 4 , Pages 517 - 522
Physical exercise in rats with epilepsy is protective against seizures: evidence of animal studies
Ricardo Mario Arida; Fulvio Alexandre Scorza; Vera Cristina Terra; Roberta Monterazzo Cysneiros; Esper Abrão Cavalheiro
Arq. Neuro-Psiquiatr. vol.67 no.4 São Paulo Dec. 2009
Lysosomal Dysfunction Results in Altered Energy Balance
Josh C. Woloszynek, Trey Coleman
¶, Clay F. Semenkovich
¶, and Mark S. Sands
1
J. Biol. Chem., Vol. 282, Issue 49, 35765-35771, December 7, 2007
A high-fat, ketogenic diet induces a unique metabolic state in mice
Adam R. Kennedy,
1 Pavlos Pissios,
1 Hasan Otu,
2 Bingzhong Xue,
1 Kenji Asakura,
1 Noburu Furukawa,
1 Frank E. Marino,
1 Fen-Fen Liu,
1 Barbara B. Kahn,
1 Towia A. Libermann,
2 and Eleftheria Maratos-Flier
1
Am J Physiol Endocrinol Metab 292: E1724-E1739, 2007
Pinealectomy reduces hepatic and muscular glycogen content and attenuates aerobic power adaptability in trained rats
Cristina das Neves Borges-Silva, Julie Takada, Maria Isabel Cardoso Alonso-Vale, Sidney B. Peres, Miriam H. Fonseca-Alaniz, Sandra Andreotti, Jose Cipolla-Neto, Tania C. Pithon-Curi and Fabio Bessa Lima
Journal of Pineal Research Volume 43 Issue 1 Page 96-103, August 2007
Dissection of the Insulin-Sensitizing Effect of Liver X Receptor Ligands
S. Renee Commerford, Leo Vargas, Suzanne E. Dorfman, Nico Mitro, Erik C. Rocheford, Puiying A. Mak, Xue Li, Patrick Kennedy, Tara L. Mullarkey and Enrique Saez
Molecular Endocrinology 21 (12): 3002-3012
The gut microbiota as an environmental factor that regulates fat storage
Fredrik Bäckhed *, Hao Ding
¶, Ting Wang
||, Lora V. Hooper**, Gou Young Koh, Andras Nagy, Clay F. Semenkovich, and Jeffrey I. Gordon *,
¶¶
PNAS | November 2, 2004 | vol. 101 | no. 44 | 15718-15723
Endothelial Nitric Oxide Synthase (eNOS) Knockout Mice Have Defective Mitochondrial {beta}-Oxidation
Eric Le Gouill
1, Maria Jimenez
2, Christophe Binnert
3, Pierre-Yves Jayet
4, Sebastien Thalmann4, Pascal Nicod
4, Urs Scherrer
4, and Peter Vollenweider
4
Diabetes 56:2690-2696, 2007
Genetic Deletion of Trb3, the Mammalian Drosophila tribbles Homolog, Displays Normal Hepatic Insulin Signaling and Glucose Homeostasis
Haruka Okamoto, Esther Latres, Rong Liu, Karen Thabet, Andrew Murphy, David Valenzeula, George D. Yancopoulos, Trevor N. Stitt, David J. Glass, and Mark W. Sleeman
Diabetes 56:1350-1356, 2007
Central CART gene delivery by recombinant AAV vector attenuates body weight gain in diet-induced-obese rats
Keyun Qing and Yanyun Chen
Regulatory Peptides Volume 140, Issues 1-2, 5 April 2007, Pages 21-26
Neuropeptide Y (NPY) Y2 receptor-selective agonist inhibits food intake and promotes fat metabolism in mice: Combined anorectic effects of Y2 and Y4 receptor-selective agonists
Ambikaipakan Balasubramaniam, Rashika Joshi, Chunhua Su, Lou Ann Friend and J. Howard James
Peptides Volume 28, Issue 2, February 2007, Pages 235-240
Loss of histaminergic modulation of thermoregulation and energy homeostasis in obese mice
J. Sethi, M. Sanchez-Alavez, I.V. Tabarean
Neuroscience Volume 217, 16 August 2012, Pages 84-95
The effect of exercise training in cold on shivering and nonshivering thermogenesis in adult and aged C57BL/6J mice
Vladimir I. Shefer and Mark I. Talan
Experimental Gerontology Volume 33, Issue 5, August 1998, Pages 467-476
Dynorphin Knockout Reduces Fat Mass and Increases Weight Loss during Fasting in Mice
Amanda Sainsbury, Shu Lin, Keely McNamara, Katy Slack, Ronaldo Enriquez, Nicola J. Lee, Dana Boey, George A. Smythe, Christoph Schwarzer, Paul Baldock, Tim Karl, En-Ju D. Lin, Michelle Couzens and Herbert Herzog
Molecular Endocrinology 21 (7): 1722-1735
PAS kinase is required for normal cellular energy balance
Huai-Xiang Hao*, Caleb M. Cardon*, Wojtek Swiatek*, Robert C. Cooksey, Tammy L. Smith*, James Wilde*, Sihem Boudina, E. Dale Abel, Donald A. McClain, and Jared Rutter*
PNAS | September 25, 2007 | vol. 104 | no. 39 | 15466-15471
Divergent Metabolic Adaptations to Intestinal Parasitic Nematode Infection in Mice Susceptible or Resistant to Obesity.
T. Wong, M. Hildebrandt, S. Thrasher, J. Appleton, R. Ahima, G. Wu
Gastroenterology , Volume 133 , Issue 6 , Pages 1979 - 1988
Systemic PPARγ Deletion Impairs Circadian Rhythms of Behavior and Metabolism
Guangrui Yang, Zhanjun Jia, Toshinori Aoyagi, Donald McClain, Richard M. Mortensen, Tianxin Yang
Research Article | published 10 Aug 2012 | PLOS ONE
10.1371/journal.pone.0038117
CTRP2 Overexpression Improves Insulin and Lipid Tolerance in Diet-Induced Obese Mice
Jonathan M. Peterson, Marcus M. Seldin, Stefanie Y. Tan, G. William Wong
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Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism
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The Carboxypeptidase E Knockout Mouse Exhibits Endocrinological and Behavioral Deficits
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The enzyme CD38 (a NAD glycohydrose, EC 3.2.2.5) is necessary for the development of diet-induced obesity
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Muscle-Specific Overexpression of CD36 Reverses the Insulin Resistance and Diabetes of MKR Mice
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Impaired Coordination of Nutrient Intake and Substrate Oxidation in Melanocortin-4 Receptor Knockout Mice
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Depletion of the p43 mitochondrial T3 receptor in mice affects skeletal muscle development and activity
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Leptin Improves Insulin Resistance and Hyperglycemia in a Mouse Model of Type 2 Diabetes
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Effects of pioglitazone on promoting energy storage, not expenditure, in brown adipose tissue of obese fa/fa zucker rats: comparison to cl 316,243.
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The induction of congenital spinal deformities in mice by maternal carbon monoxide exposure.
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Diaspirin cross-linked Hb and norepinephrine prevent the sepsis-induced increase in critical O2 delivery
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Effect of hydroxycitrate on respiratory quotient, energy expenditure, and glucose tolerance in male rats after a period of restrictive feeding*1
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Inactivation of PKC{theta} Leads to Increased Susceptibility to Obesity and Dietary Insulin Resistance in Mice
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Decreased food intake rather than zinc deficiency is associated with changes in plasma leptin, metabolic rate, and activity levels in zinc deficient rats.
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PYY[3-36] Administration Decreases the Respiratory Quotient and Reduces Adiposity in Diet-Induced Obese Mice1
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LMO4 Is Essential for Paraventricular Hypothalamic Neuronal Activity and Calcium Channel Expression to Prevent Hyperphagia
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Androgen Receptor Null Male Mice Develop Late-Onset Obesity Caused by Decreased Energy Expenditure and Lipolytic Activity but Show Normal Insulin Sensitivity With High Adiponectin Secretion
WuQiang Fan
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Double Leptin and Melanocortin-4 Receptor Gene Mutations Have an Additive Effect on Fat Mass and Are Associated with Reduced Effects of Leptin on Weight Loss and Food Intake
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NPY modulates PYY function in the regulation of energy balance and glucose homeostasis
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GM-CSF action in the CNS decreases food intake and body weight
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The Regulation of Feeding and Metabolic Rate and the Prevention of Murine Cancer Cachexia with a Small-Molecule Melanocortin-4 Receptor Antagonist
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Wnt10b Inhibits Development of White and Brown Adipose Tissues*
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Anabolic Impact of Cimaterol in Conjunction with Enteral Nutrition following Burn Trauma
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Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase–1
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Green tea extract improves endurance capacity and increases muscle lipid oxidation in mice
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Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
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Absence of the Glucagon-Like Peptide-1 Receptor Does Not Affect the Metabolic Phenotype of Mice with Liver-Specific Gsα Deficiency
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Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
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Targeted Intestinal Overexpression of the Immediate Early Gene tis7 in Transgenic Mice Increases Triglyceride Absorption and Adiposity*
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Metabolic Adaptations of Three Inbred Strains of Mice (C57BL/6, DBA/2, and 129T2) in Response to a High-Fat Diet1
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Body weight-dependent troponin T alternative splicing is evolutionarily conserved from insects to mammals and is partially impaired in skeletal muscle of obese rats
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IL-15 Overexpression Promotes Endurance, Oxidative Energy Metabolism, and Muscle PPARδ, SIRT1, PGC-1α, and PGC-1β Expression in Male Mice
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Consuming Fructose-sweetened Beverages Increases Body Adiposity in Mice
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Deletion of the RIIß-Subunit of Protein Kinase A Decreases Body Weight and Increases Energy Expenditure in the Obese, Leptin-Deficient ob/ob Mouse
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C75 Alters Central and Peripheral Gene Expression to Reduce Food Intake and Increase Energy Expenditure
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LXRß IS REQUIRED FOR ADIPOCYTE GROWTH, GLUCOSE HOMEOSTASIS AND ß
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Mice with selective elimination of striatal acetylcholine release are lean, show altered energy homeostasis and changed sleep/wake cycle
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Journal of Neurochemistry
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Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal
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PNAS | February 15, 2005 | vol. 102 | no. 7 | 2537-2542
A novel and selective beta-MSH derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats
Hansen M. Hsiung
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1, Xing-yue Zhang
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Mark L. Heiman
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Mo
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Endocrinology. First published September 15, 2005 as doi:10.1210/en.2005-0177
Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice
David Porter, Emilie Faivre, Peter R. Flatt, Christian Hölscher, Victor A. Gault
Peptides
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Exercise and Green Tea Extract Stimulate Fat Oxidation and Prevent Obesity in Mice.
SHIMOTOYODOME, AKIRA; HARAMIZU, SATOSHI; INABA, MISAKO; MURASE, TAKATOSHI; TOKIMITSU, ICHIRO
Medicine & Science in Sports & Exercise. 37(11):1884-1892, November 2005.
Energetics of a long-distance migrant shorebird (Philomachus pugnax) during cold exposure and running
Eric Vaillancourt
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1, François Haman
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Journal of Experimental Biology 208, 317-325 (2005)
Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice
Qiang Wang, Konstantin Levay, Tatyana Chanturiya, Galina Dvoriantchikova, Karen L. Anderson, Suzy D. C. Bianco, Cintia B. Ueta, R. Damaris Molano, Antonello Pileggi, Eugenia V. Gurevich, Oksana Gavrilova and Vladlen Z. Slepak
The FASEB Journal vol. 25 no. 11 3949-3957
Energy Metabolic Profile of Mice after Chronic Activation of Central NPY Y1, Y2, or Y5 Receptors
Melanie Henry, Lorraine Ghibaudi, Jun Gao and Joyce J. Hwa
Obesity Research 13:36-47 (2005)
Limited Exercise Capacity in Heterozygous Manganese Superoxide Dismutase Gene–Knockout Mice
Roles of Superoxide Anion and Nitric Oxide
Shintaro Kinugawa, MD, PhD; Ziping Wang, AASA; Pawel M. Kaminski, MD, PhD; Michael S. Wolin, PhD; John G. Edwards, PhD; Gabor Kaley, PhD; Thomas H. Hintze, PhD
Circulation. 2005;111:1480-1486
Late-Onset Leanness in Mice with Targeted Ablation of Melanin Concentrating Hormone Neurons
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The Journal of Neuroscience, January 11, 2006 - 26(2):389-397
Effects of the presence, absence, and overexpression of uncoupling protein-3 on adiposity and fuel metabolism in congenic mice
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AJP - Endo 290:1304-1312, 2006
High intensity interval training alters substrate utilization and reduces oxygen consumption in the heart
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A Transgenic Mouse with a Deletion in the Collagenous Domain of Adiponectin Displays Elevated Circulating Adiponectin and Improved Insulin Sensitivity
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Endocrinology Vol. 145, No. 1 367-383
Pheromone-induced anorexia in male Syrian hamsters
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2 Wei Fan,
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Am J Physiol Endocrinol Metab 285: E1028-E1038, 2003
Inactivation of the Mitochondrial Carrier SLC25A25 (ATP-Mg2+/Pi Transporter) Reduces Physical Endurance and Metabolic Efficiency in Mice*
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Absence of Cocaine- and Amphetamine-Regulated Transcript Results in Obesity in Mice Fed a High Caloric Diet
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Acylation-stimulating Protein (ASP) Deficiency Induces Obesity Resistance and Increased Energy Expenditure in ob/ob Mice
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Abnormal Cardiac Function Associated with
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Energy expenditure of rats subjected to long-term food restriction
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Stanniocalcin 1 Alters Muscle and Bone Structure and Function in Transgenic Mice
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Activation of stress signaling molecules in bat brain during arousal from hibernation
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Identification of a biochemical link between energy intake and energy expenditure
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Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner
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A Tailored Therapy for the Metabolic Syndrome
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Diabetes 51:1083-1087, 2002
Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice
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VITAMIN E ADMINISTRATION ATTENUATES THE TRI-IODOTHYRONINEINDUCED
MODIFICATION OF HEART ELECTRICAL ACTIVITY IN THE RAT
PAOLA VENDITTI, TEODORO DE LEO AND SERGIO DI MEO*
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Suppression of body fat accumulation in myostatin-deficient mice
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Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats
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Interindividual Variation in Posture Allocation: Possible Role in Human Obesity
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The Corepressor NCoR1 Antagonizes PGC-1α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism
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Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of
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Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet–Fed Mice
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Systemic Administration of the Long-Acting GLP-1 Derivative NN2211
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Diabetes 50:2530-2539, 2001
NPY ablation in C57BL/6 mice leads to mild obesity and to an impaired refeeding response to fasting
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Suppression of the C/EBP family of transcription factors in adipose tissue causes lipodystrophy
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Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti
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A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors
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Selective thyroid hormone receptor-ß activation: A strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability
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Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance
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SRC-1 and TIF2 Control Energy Balance
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Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals*
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Hematopoietic Cell–Restricted Deletion of CD36 Reduces High-Fat Diet–Induced Macrophage Infiltration and Improves Insulin Signaling in Adipose Tissue
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GH-Releasing Peptide-2 Increases Fat Mass in Mice Lacking NPY: Indication for a Crucial Mediating Role of Hypothalamic Agouti-Related Protein
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High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity
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Hyperactivity and Reduced Energy Cost of Physical Activity in Serotonin 5-HT2C Receptor Mutant Mice
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1Diabetes 52:315-320, 2003
Increased energy expenditure and leptin sensitivity account for low fat mass in myostatin-deficient mice
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DHEA administration increases brown fat uncoupling
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Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism
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PNAS | March 5, 2002 | vol. 99 | no. 5 | 3240-3245
Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats
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Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference
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Nuclear receptor corepressor RIP140 regulates fat accumulation
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Anaplerotic Triheptanoin Diet Enhances Mitochondrial Substrate Use to Remodel the Metabolome and Improve Lifespan, Motor Function, and Sociability in MeCP2-Null Mice
Min Jung Park, Susan Aja, Qun Li, Alicia L. Degano, Judith Penati, Justin Zhuo, Charles R. Roe, Gabriele V. Ronnett
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C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity
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PNAS, June 11, 2002, 10.1073/pnas.132128899
Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype
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PNAS | August 19, 2003 | vol. 100 | no. 17 | 10085-10090
Dihydrotestosterone Treatment Results in Obesity and Altered Lipid Metabolism in Orchidectomized Mice
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Bovine Growth Hormone Transgenic Mice Are Resistant to Diet-Induced Obesity but Develop Hyperphagia, Dyslipidemia, and Diabetes on a High-Fat Diet
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Key Electrophysiological, Molecular, and Metabolic Signatures of Sleep and Wakefulness Revealed in Primary Cortical Cultures
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Transgenic Mice Expressing Human Fibroblast Growth Factor-19 Display Increased Metabolic Rate and Decreased Adiposity
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Copyright © 2002
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Exp Physiol 88.3
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SCIENCE VOL 297 12 JULY 2002
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Hepatology; Volume 42, Issue 2 , Pages 362 - 371
Overexpression of Fto leads to increased food intake and results in obesity
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Ene Metabolism Of The Virginia During Fasting And Exercise
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Oksana Gavrilova, Bernice Marcus-Samuels, David Graham, Jason K. Kim, Gerald I. Shulman, Arthur L. Castle, Charles Vinson, Michael Eckhaus, and Marc L. Reitman
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